全文获取类型
收费全文 | 1649篇 |
免费 | 88篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 27篇 |
妇产科学 | 11篇 |
基础医学 | 258篇 |
口腔科学 | 29篇 |
临床医学 | 111篇 |
内科学 | 401篇 |
皮肤病学 | 12篇 |
神经病学 | 115篇 |
特种医学 | 26篇 |
外科学 | 382篇 |
综合类 | 5篇 |
预防医学 | 36篇 |
眼科学 | 16篇 |
药学 | 152篇 |
中国医学 | 4篇 |
肿瘤学 | 148篇 |
出版年
2023年 | 16篇 |
2022年 | 11篇 |
2021年 | 37篇 |
2020年 | 23篇 |
2019年 | 36篇 |
2018年 | 37篇 |
2017年 | 19篇 |
2016年 | 26篇 |
2015年 | 28篇 |
2014年 | 37篇 |
2013年 | 56篇 |
2012年 | 74篇 |
2011年 | 80篇 |
2010年 | 43篇 |
2009年 | 36篇 |
2008年 | 75篇 |
2007年 | 86篇 |
2006年 | 95篇 |
2005年 | 70篇 |
2004年 | 70篇 |
2003年 | 70篇 |
2002年 | 66篇 |
2001年 | 58篇 |
2000年 | 47篇 |
1999年 | 47篇 |
1998年 | 22篇 |
1997年 | 22篇 |
1996年 | 24篇 |
1995年 | 17篇 |
1994年 | 14篇 |
1993年 | 14篇 |
1992年 | 46篇 |
1991年 | 25篇 |
1990年 | 35篇 |
1989年 | 26篇 |
1988年 | 26篇 |
1987年 | 41篇 |
1986年 | 24篇 |
1985年 | 22篇 |
1984年 | 10篇 |
1983年 | 18篇 |
1982年 | 11篇 |
1979年 | 11篇 |
1978年 | 9篇 |
1976年 | 7篇 |
1975年 | 10篇 |
1974年 | 11篇 |
1973年 | 10篇 |
1970年 | 10篇 |
1967年 | 9篇 |
排序方式: 共有1751条查询结果,搜索用时 31 毫秒
31.
Wang L Kuroiwa Y Kamitani T Li M Takahashi T Suzuki Y Shimamura M Hasegawa O 《Journal of neurology》2000,247(5):356-363
To determine whether there are characteristic changes in event-related potentials (ERPs) in parkinsonian syndromes we studied
8 patients with progressive supranuclear palsy (PSP), 10 patients with corticobasal degeneration (CBD), 9 patients with striatonigral
degeneration (SND), and 16 patients with idiopathic Parkinson's disease (PD) with a mean duration of illness shorter than
5 years in each group. A visual oddball paradigm was employed to elicit P300. P300 to the rare target and rare nontarget stimuli
and reaction time (RT) to rare target stimuli in each group were compared with those in the corresponding age-matched normal
control group and to each other after age correction. The correlation of P300 and RT to motor disability score was also studied.
In PSP P300 amplitude was markedly reduced while in CBD P300 latency was prolonged. P300 amplitude to rare nontargets in SND
and PD was attenuated. The mean RT in the PSP and the CBD group was significantly longer than in the other two groups. The
mean RT in PD and P300 amplitude to rare nontargets in both CBD and PD showed significant correlation with the severity of
motor disability. Simultaneous measurement of P300 and RT may yield useful supplementary information in facilitating diagnosis
of parkinsonian syndromes in addition to clinical criteria.
Received: 6 April 1999, Received in revised form: 5 August 1999, Accepted: 12 January 2000 相似文献
32.
Thanh Binh Nguyen Hiroyuki Ida Mai Shimamura Daishi Kitazawa Shinichi Akao Hideki Yoshida Yoshihiro H Inoue Masamitsu Yamaguchi 《American journal of cancer research》2014,4(4):325-336
In man, COX (cytochrome c oxidase) deficiency is reported to be related to mutation of the SCO2 (synthesis of cytochrome c oxidase 2) gene, which encodes one of the copper-donor chaperones involved in the assembly of mitochondrial cytochrome c oxidase. Such COX deficiency due to the genetic condition leads to heart disease and the Leigh syndrome and is frequently fatal in childhood. Synthesis of cytochrome c oxidase X (SCOX) is a Drosophila orthologue of human SCO2. Here, we generated SCOX-knockdown flies and the full length SCOX transgenic flies to investigate the in vivo roles of SCOX. Our results demonstrated knockdown of SCOX gene in all cells and tissues to be associated with lethality at larval or pupal stages and this correlated with a decrease in ATP level. In contrast, the full length SCOX transgenic flies showed a longer lifespan than wild type flies and control flies carrying Act5C-GAL4 alone and this correlated with an increase in ATP level. Finally, when cultured on paraquat-added medium, full length SCOX transgenic flies also exhibited an elongated lifespan. Therefore, we hypothesized that SCOX plays an important role in ATP production and consumption, which helps to prevent production of mitochondrial reactive oxygen species and/or impairment of mitochondrial activity under oxidative stress. 相似文献
33.
Masahiko Yamamoto Kazuo Ishikawa Mitsuhiro Aoki Keisuke Mizuta Yatsuji Ito Masatsugu Asai Hideo Shojaku Toshiaki Yamanaka Chisato Fujimoto Toshihisa Murofushi Tomoe Yoshida 《Auris, nasus, larynx》2018,45(2):201-206
Stabilometry is a useful tool for examining patients with functional disorders of the vestibular system. However, measurement techniques and devices vary by country. Therefore, international standardization of stabilometry is mandatory to validate the exchange of important findings. This was advocated at the 1983 Posturography Meeting in Kyoto but has not been adopted worldwide, and each country has continued to use unique regional measurement methods. In Japan, stabilometry has widespread application in medical practice in conjunction with research into its applications. With a goal of international standardization, we present details of stabilometry measurement methods and their application in Japan, together with a brief history and potential future directions of stabilometry. 相似文献
34.
35.
Hayashi Yuki Wagatsuma Kohei Nojima Masanori Yamakawa Tsukasa Ichimiya Tadashi Yokoyama Yoshihiro Kazama Tomoe Hirayama Daisuke Nakase Hiroshi 《Journal of gastroenterology》2021,56(5):421-421
Journal of Gastroenterology - A correction to this paper has been published: https://doi.org/10.1007/s00535-021-01786-z 相似文献
36.
37.
38.
Numerical chromosomal abnormality in gastric MALT lymphoma and diffuse large B-cell lymphoma 总被引:1,自引:0,他引:1
Watanobe I Takamori S Kojima K Fukasawa M Beppu T Futagawa S Hirai S 《Journal of gastroenterology》2002,37(9):691-696
Background: We investigated numerical chromosomal abnormalities, using the fluorescence in situ hybridization (FISH) method, in gastric
mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBL). We also compared the histopathological
findings, including the presence or absence of Helicobacter pylori infection, with the analytical results. Methods: Sixteen patients who underwent operation for malignant gastric lymphoma in our department were divided into three groups:
patients with low-grade gastric MALT lymphoma (l-MALT; n = 5), those with high-grade gastric MALT lymphoma (h-MALT; n = 8), and those with DLBL (n = 3). Numerical abnormalities of chromosomes 8, 9, 12, and 17 were investigated by the FISH method, and the presence or absence
of H. pylori infection was microscopically examined. Results: Numerical abnormality was observed in chromosome 12 in 11 patients (68.8%), in chromosome 8 in 10 (62.5%), and in chromosome
17 in 5 (31.3%), showing a high frequency. H. pylori infection was detected in 80% and 50% of patients with l-MALT and h-MALT, respectively, but no H. pylori infection was observed in patients with DLBL. Conclusions: A new biological characteristic of gastric MALT lymphoma was obtained, i.e., a high frequency of numerical abnormalities
of chromosomes 12, 8, and 17. There was no correlation between the numerical chromosomal abnormalities and the clinicopathological
findings.
Received: September 5, 2001 / Accepted: February 22, 2002
Acknowledgments. We sincerely appreciate the instruction and cooperation provided by Mr. A. Furuhata, Mr. S. Nakamura, and the staff, Department
of Collaborative Pathology, Juntendo University, Tokyo, Japan.
Reprint requests to: I. Watanobe 相似文献
39.
Morishita E Sekiya A Hayashi T Kadohira Y Maekawa M Yamazaki M Asakura H Nakao S Ohtake S 《International journal of hematology》2008,88(3):272-277
Previous studies have found markedly elevated serum concentrations of proinflammatory cytokines in patients with Graves’ disease
(GD). We investigated the role of macrophage colony-stimulating factor (M-CSF) in GD. We assayed concentrations of M-CSF in
sera from 32 patients with GD (25 untreated; 7 receiving thiamazole therapy). We also studied 32 age-matched healthy subjects
as controls. Relationships between serum M-CSF and both thyroid state and serum lipids were examined. Moreover, to examine
the effect of thyroid hormone alone on serum M-CSF, T3 was administered orally to normal subjects. Serum concentrations of
M-CSF in GD patients who were hyperthyroid were significantly increased compared with GD patients who were euthyroid (P < 0.05) and control subjects (P < 0.0001). Serum M-CSF concentrations correlated closely with T3 levels in patients (r = 0.51, P < 0.005). Serial measurement of five individual patients revealed that serum concentrations of M-CSF were significantly decreased
(P < 0.05), reaching normal control values upon attainment of euthyroidism. Furthermore, oral T3 administered to 15 volunteers
for 7 days produced significant increases in serum levels of M-CSF (P < 0.05). The close correlation between serum M-CSF and serum thyroid hormone levels suggests that high circulating levels
of thyroid hormones may directly or indirectly potentiate the production of M-CSF in patients with GD. 相似文献
40.
H Chosa M Toda S Okubo Y Hara T Shimamura 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》1992,66(5):606-611
We examined tea extracts, (-) epigallocatechin gallate (EGCg) and theaflavin digallate (TF3) for their antimicrobial and microbicidal activities against Mycoplasma. Green tea and black tea showed antimicrobial activities against M. pneumoniae. At a concentration of 0.2% green tea and black tea showed microbicidal activities against M. pneumoniae and M. orale but not against M. salivarium. Extracts of pu-erh tea showed a slight microbicidal activity against M. pneumoniae and M. orale. EGCg purified from green tea and TF3 from black tea markedly showed microbicidal activities against M. pneumoniae. M. orale and M. salivarium. These results suggest that tea and catechins can be used as prophylactic agents against Mycoplasma pneumoniae infection. 相似文献