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191.
W.J. PENHALE S. ANSAR AHMED 《American journal of reproductive immunology (New York, N.Y. : 1989)》1981,1(6):326-330
ABSTRACT: Female rats of the PVG/c strain were found to be approximately four times more susceptible than males to the induction of autoimmune thyroiditis by thymectomy and irradiation (Tx-X) (female vs male incidence, 60%:14%). Similarly, the severity of the lesion was generally greater in females than males. Female Tx-X rats also had a significantly higher incidence of antibodies to thyro-globulin than males (incidence, 67%:24%, respectively) and developed higher titers. Prepubertal orchiectomy had a profound influence on both the severity and incidence of thyroiditis. Orchiectomized Tx-X males were found to have changes approximating those of Tx-X females (72%:60%, respectively). A corresponding influence was also noted on the incidence and titer of antibodies to thyroglobulin (incidence, 78%:67%, respectively). Postpubertal orchiectomy similarly intensified the incidence and severity of the disease. Ovariectomy also caused a slight but significant increase in autoimmune thyroiditis as compared to entire Tx-X females (78%:60%, respectively). Sham-gonadectomized control rats did not differ in overall susceptibility from entire Tx-X rats. These observations indicate that the incidence and extent of autoimmunity induced in this particular model are modulated by sex steroid hormone production rather than by sex-linked gene(s) directly determining susceptibility. It is also apparent that this influence is not exerted through the thymus gland. 相似文献
192.
L.-Z. PAN M. J. DAUPHINÉE S. ANSAR AHMED N. TALAL 《Scandinavian journal of immunology》1986,23(4):415-423
Three strains of mice bearing the autosomal recessive lpr gene (MRL, C57BL/6, and C3H) that had spontaneously developed a lupus-like disease were studied sequentially for functional natural killer (NK) and natural cytotoxic (NC) cell activity. Natural killing was impaired in spleen and bone marrow cells from all the lpr strains, as well as from the congenic strain MRL--+/+, which develops a late onset lupus-like disease. The NK cell activity was found to be depleted as early as 2 months of age in all lpr strains, and decreased further with age. NK activity was augmentable by Poly I:C and interleukin 2 (IL-2), suggesting that the residual cells can respond to NK modulators. In contrast with NK cell activity, NC activity was not decreased in lpr mice but could be augmented by IL-3-rich supernatants. The spontaneous decrease in NK cell activity was associated with an increased autologous plaque-forming cell (APFC) response to bromelin-treated mouse red blood cells, which is produced primarily by B cells possessing the Ly-1 phenotype (Lyt-1+ B). When NK cell activity was increased by exogenous administration of Poly I:C, the APFC response diminished. Treatment of spleen cells with anti-asialo GM1 prior to Poly I:C treatment resulted in a decreased NK response but increased both APFC and Lyt-1+ B cells. The possible regulation of autoreactivity by NK cells is discussed. 相似文献
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A genome-based study of consanguinity in three co-resident endogamous Pakistan communities 总被引:1,自引:1,他引:0
W. WANG S. G. SULLIVAN S. AHMED D. CHANDLER L. A. ZHIVOTOVSKY A. H. BITTLES 《Annals of human genetics》2000,64(1):41-49
In a study based on 173 individuals drawn from three endogamous, co-resident communities in the province of Punjab, the Awan, Khattar and Rajpoot, an analysis of 10 autosomal single tandem repeats on chromosomes 13 and 15 revealed distinctive genetic profiles in each community. A total of 99 different alleles were detected, with 28 alleles (28.3%) shared by all three communities. The mean private allele frequency was 7.7%. There was a reduction in heterozygosity and high average inbreeding effects ( F IS and/or H S ), particularly in the Awan, indicating genetic isolation and a high cumulative level of autozygosity. Genotyping with eight Y-chromosome STRs resulted in the construction of six haplotypes, one each for the Awan and the Khattar but four for the Rajpoot, suggesting marked variation in the patterns of male founder effects in the history of each community. The lower than expected levels of homozygosity observed at a number of loci may be indicative of cosegregation of the STRs with nearby early development genes subject to selection. 相似文献
196.
Efavirenz Inhibits the Human Ether‐A‐Go‐Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers
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AHMED M. ABDELHADY M.Sc. TYLER SHUGG Pharm.D. NANCY THONG M.S.N. JESSICA BO LI LU M.Sc. YVONNE KREUTZ M.Sc. HEATHER A. JAYNES M.S.N. JASON D. ROBARGE Ph.D. JAMES E. TISDALE Pharm.D. ZERUESENAY DESTA Ph.D. BRIAN R. OVERHOLSER Pharm.D. 《Journal of cardiovascular electrophysiology》2016,27(10):1206-1213
197.
Ravi Gupta Tanzeel Ahmed Basudeb Banerjee Manjeet Bhatia 《The journal of headache and pain》2009,10(3):161-166
Calcitonin gene-related peptide (CGRP) is known to increase during acute attack of migraine and tension type headache (TTH).
However, its concentration during inter-ictal period is not known. This may help us to understand the pathophysiology of these
headaches. The objectives of this study are to find out the concentration of CGRP in plasma during inter-ictal period among
migraineurs and TTH and to compare it with control group through cross-sectional study from headache clinic of a tertiary
centre. Study sample comprised of three groups: migraineurs, TTH subjects as well as a healthy control group. Fifty subjects
in each group were included after screening for the respective inclusion criteria and exclusion criteria. None of the subjects
was blood relatives of other subject. Their venous blood was drawn and plasma was separated to be kept at −70°C. CGRP was
analysed with commercially available ELISA kit. Data were analysed with the help of SPSS V 11.0 for Windows. Chi-square, independent
sample t test and one-way ANOVA with post hoc Tukey and univariate regression were performed. Plasma CGRP concentration was not different
among three diagnostic groups (F = 0.78; P = 0.49). Similarly, plasma CGRP concentration was not different among episodic TTH and chronic TTH groups (t = 0.32; P = 0.97) and comparison of episodic and chronic migraine groups also revealed similar results in this study (1.14 vs. 0.94 ng/ml;
P = 0.23). The presence of aura did not affect the inter-ictal CGRP levels among migraineurs (F = 0.16; P = 0.85). In conclusion, this study suggests that migraine and TTH could be episodic disorders and subjects have comparable
CGRP levels during inter-ictal period. 相似文献
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MOHAMED ALI AL KARAWI SOHAIL SHARIQ ABDEL RAHMAN EL SHIEKH MOHAMED AWAD A. SAEED ABDUL MUTAAL MOHAMED AHMED 《Journal of gastroenterology and hepatology》1992,7(3):237-239
The prevalence of antibody to hepatitis C virus (HCV) was determined in 139 patients with chronic liver disease (CLD) and 42 patients with hepatocellular carcinoma (HCC) during one year at the Riyadh Military Hospital, Saudi Arabia. The anti-HCV was detected in 36 of 96 (37.5%) HBsAg-negative patients with chronic liver disease and six of 43 (13.9%) HBsAg-positive patients with chronic liver disease. In addition, 11 (42.3%) HBsAg-negative hepatocellular carcinoma patients and two of 16 (12.5%) HBsAg-positive hepatocellular patients had antibody to HCV. The anti-HCV prevalence was 1.5% in 4818 healthy blood donors and 1% in 385 antenatal patients. The overall HCV seropositivity of 30.4% in 181 liver disease patients (CLD and HCC) in Saudi Arabia is lower than that reported from European countries. 相似文献