全文获取类型
收费全文 | 4702篇 |
免费 | 318篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 148篇 |
妇产科学 | 109篇 |
基础医学 | 714篇 |
口腔科学 | 128篇 |
临床医学 | 367篇 |
内科学 | 1126篇 |
皮肤病学 | 217篇 |
神经病学 | 537篇 |
特种医学 | 44篇 |
外科学 | 323篇 |
综合类 | 21篇 |
预防医学 | 406篇 |
眼科学 | 145篇 |
药学 | 373篇 |
中国医学 | 33篇 |
肿瘤学 | 330篇 |
出版年
2024年 | 3篇 |
2023年 | 38篇 |
2022年 | 89篇 |
2021年 | 170篇 |
2020年 | 101篇 |
2019年 | 163篇 |
2018年 | 178篇 |
2017年 | 127篇 |
2016年 | 147篇 |
2015年 | 156篇 |
2014年 | 216篇 |
2013年 | 253篇 |
2012年 | 437篇 |
2011年 | 422篇 |
2010年 | 238篇 |
2009年 | 187篇 |
2008年 | 341篇 |
2007年 | 288篇 |
2006年 | 271篇 |
2005年 | 285篇 |
2004年 | 255篇 |
2003年 | 221篇 |
2002年 | 230篇 |
2001年 | 12篇 |
2000年 | 9篇 |
1999年 | 30篇 |
1998年 | 29篇 |
1997年 | 24篇 |
1996年 | 21篇 |
1995年 | 13篇 |
1994年 | 8篇 |
1993年 | 12篇 |
1992年 | 9篇 |
1991年 | 8篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1978年 | 3篇 |
1976年 | 1篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有5040条查询结果,搜索用时 15 毫秒
991.
Rosacea-like demodicidosis in an immunocompromised child 总被引:5,自引:0,他引:5
Demodex folliculorum is a saprophytic mite of the human pilosebaceous unit. It is rarely found in children. It has been implicated in the development of follicular pityriasis, rosacea-like demodicidosis, pustular folliculitis, blepharitis, and granulomatous rosacea. We describe a 4-year-old boy who developed asymptomatic facial lesions that histologically corresponded to demodicidosis. He was in clinical remission of acute lymphoblastic leukemia and currently receiving maintenance chemotherapy. Exanthems related to D. folliculorum are rare in children. Most cases occur in immunocompromised patients and the clinical and histologic findings are diverse. A differential diagnosis should be established with rosacea and perioral dermatitis. The role of Demodex in the pathogenesis of these disorders is controversial. Immunosuppression might increase the number of mites, favoring an inflammatory reaction, or there could exist an impaired cutaneous immunologic response to the parasites. 相似文献
992.
Susana R Patton Laura B Williams Sally J Eder Megan J Crawford Lawrence Dolan Scott W Powers 《Pediatric diabetes》2011,12(1):18-24
Patton SR, Williams LB, Eder SJ, Crawford MJ, Dolan L, Powers SW. Use of continuous glucose monitoring in young children with type 1 diabetes: implications for behavioral research. Objective: This study presents data on the use of continuous glucose monitoring (CGM) in young children with type 1 diabetes mellitus (T1DM). CGM provides moment‐to‐moment tracking of glucose concentrations and measures of intra‐ and interday variability, which are particularly salient measures in young children with T1DM. Methods: Thirty‐one children (mean age = 5.0 yr ) with T1DM wore the Medtronic Minimed CGM for a mean of 66.8 h. The CGM was inserted in diabetes clinics, and parents were provided brief training. Results: Few difficulties were experienced and families cited the acceptability of CGM. Participants' CGM data are compared with self‐monitoring blood glucose (SMBG) data as well as data from older children with T1DM to illustrate differences in methodology and variability present in this population. CGM data are used to calculate glucose variability, which is found to be related to diabetes variables such as history of hypoglycemic seizures. Conclusions: CGM is an acceptable research tool for obtaining glucose data in young children with T1DM and has been used previously in older children and adults. CGM may be particularly useful in young children who often experience more glucose variability. Data obtained via CGM are richer and more detailed than traditional SMBG data and allow for analyses to link blood glucose with behavior. 相似文献
993.
Montaña Diaz-Manzano José Juan Robles-Pérez Ketty Herrera-Mendoza Beliña Herrera-Tapias Jesús Fernández-Lucas Susana Aznar-Lain Vicente Javier Clemente-Suárez 《Journal of medical systems》2018,42(5):84
Caffeine is one of the ergogenic substances most used by warfighters in current operation areas, but the effect on the organic response and operational performed is already poor knowledge. This research aimed to study the acute effect of 400 mg of caffeine monohydrate on the psycho-physiological response and rifle marksmanship of warfighters during a close quarter combat simulation. We analysed parameter of heart rate, blood lactate, cortical arousal, state anxiety and marksmanship of 20 Spanish Army veteran warfighters before and after a close quarter combat simulation in a double-blind procedure, also a correlation analysis was conducted between all the study variables. Marksmanship of warfighters did not improve with the caffeine ingestion, but it produced an increase in blood lactate concentration (caffeine: 1.9?±?0.5 vs. 9.2?±?1.1 mmol.l?1; placebo: 1.8?±?0.7 vs. 6.9?±?2.2 mmol.l?1), cortical arousal (% of change: caffeine: 2.51; placebo: ?1.96) and heart rate (caffeine: 80.0?±?7.2 vs. 172.9?±?28.2 bpm; placebo: 79.3?±?6.4 vs. 154.0?±?26.8 bpm). In addition, higher heart rate values correlated negatively with marksmanship in close quarter combat. We concluded that caffeine intake did not improve the warfighters rifle marksmanship in close quarter combat possibly due to the increase in the physiological response. 相似文献
994.
Pereira Ruben Silveira João Dias Susana Cardoso Ana Mata António Marques Duarte 《Clinical oral investigations》2022,26(12):7167-7177
Clinical Oral Investigations - To evaluate bleaching efficacy and oral health-related quality of life (ORHQoL) of three bleaching systems with similar hydrogen peroxide (HP) concentration for up to... 相似文献
995.
996.
997.
Argenziano G Zalaudek I Hofmann-Wellenhof R Bakos RM Bergman W Blum A Broganelli P Cabo H Caltagirone F Catricalà C Coppini M Dewes L Francia MG Garrone A Turk BG Ghigliotti G Giacomel J Gourhant JY Hlavin G Kukutsch N Lipari D Melchionda G Ozdemir F Pellacani G Pellicano R Puig S Scalvenzi M Sortino-Rachou AM Virgili AR Kittler H 《Journal of the American Academy of Dermatology》2012,66(2):212-219
998.
Baselga E Wassef M Lopez S Hoffman W Cordisco M Frieden IJ 《Pediatric dermatology》2012,29(2):186-190
We report three infants who developed agminated pyogenic granulomas over congenital vascular malformations, all of which had an aggressive growth pattern. There were no precipitating events such as laser therapy or surgery. Lesions were excised. 相似文献
999.
Langerhans cell histiocytosis (LCH) is a heterogeneous group of diseases characterized by a pathological proliferation of cells phenotypically similar to Langerhans cells. The disease course is variable, alternating between resolving and potentially fatal forms. The diagnosis is based on clinical appearance and confirmed by CD1a positivity and / or immunohistochemistry. We report the case of a male child of 3 months with two different presentations of Langerhans cell-histiocytosis (LCH) at different times. The first presentation was classified as a self-healing LCH (formerly known as Hashimoto-Pritzker). The last presentation, although clinically suggestive of Letterer-Siwe (former designation), was not associated with systemic disease. This emphasizes that LCH cannot be compartmentalized into four groups, but considered a single disease with a wide spectrum of clinical presentations. This case underscores the importance of frequent and long-term follow-up of these patients. 相似文献
1000.
Susana Marcos Jose Requejo-Isidro Jesus Merayo-Lloves A. Ulises Acu?a Valentin Hornillos Eugenia Carrillo Pablo Pérez-Merino Susana del Olmo-Aguado Carmen del Aguila Francisco Amat-Guerri Luis Rivas 《Biomedical optics express》2012,3(10):2489-2499
Acanthamoeba keratitis is a serious pathogenic corneal disease,
with challenging diagnosis. Standard diagnostic methods include corneal biopsy
(involving cell culture) and in vivo reflection corneal
microscopy (in which the visualization of the pathogen is challenged by the
presence of multiple reflectance corneal structures). We present a new imaging
method based on fluorescence sectioned microscopy for visualization of
Acanthamoeba. A fluorescent marker (MT-11-BDP), composed by
a fluorescent group (BODIPY) inserted in miltefosine (a therapeutic agent
against Acanthamoeba), was developed. A custom-developed
fluorescent structured illumination sectioned corneal microscope (excitation
wavelength: 488 nm; axial/lateral resolution: 2.6 μm/0.4-0.6 μm)
was used to image intact enucleated rabbit eyes, injected with a solution of
stained Acanthamoeba in the stroma. Fluorescent sectioned
microscopic images of intact enucleated rabbit eyes revealed stained
Acanthamoeba trophozoites within the stroma, easily
identified by the contrasted fluorescent emission, size and shape. Control
experiments show that the fluorescent maker is not internalized by corneal
cells, making the developed marker specific to the pathogen. Fluorescent
sectioned microscopy shows potential for specific diagnosis of
Acanthamoeba keratitis. Corneal confocal microscopy,
provided with a fluorescent channel, could be largely improved in specificity
and sensitivity in combination with specific fluorescent marking.OCIS codes: (180.0180) Microscopy, (170.4470) Ophthalmology, (170.4460) Ophthalmic optics and devices 相似文献