全文获取类型
收费全文 | 4784篇 |
免费 | 299篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 166篇 |
妇产科学 | 103篇 |
基础医学 | 770篇 |
口腔科学 | 60篇 |
临床医学 | 328篇 |
内科学 | 918篇 |
皮肤病学 | 82篇 |
神经病学 | 314篇 |
特种医学 | 79篇 |
外科学 | 495篇 |
综合类 | 133篇 |
一般理论 | 4篇 |
预防医学 | 372篇 |
眼科学 | 171篇 |
药学 | 550篇 |
中国医学 | 76篇 |
肿瘤学 | 455篇 |
出版年
2023年 | 24篇 |
2022年 | 63篇 |
2021年 | 114篇 |
2020年 | 84篇 |
2019年 | 105篇 |
2018年 | 128篇 |
2017年 | 86篇 |
2016年 | 109篇 |
2015年 | 140篇 |
2014年 | 173篇 |
2013年 | 262篇 |
2012年 | 355篇 |
2011年 | 380篇 |
2010年 | 221篇 |
2009年 | 165篇 |
2008年 | 277篇 |
2007年 | 257篇 |
2006年 | 280篇 |
2005年 | 239篇 |
2004年 | 199篇 |
2003年 | 162篇 |
2002年 | 170篇 |
2001年 | 100篇 |
2000年 | 103篇 |
1999年 | 69篇 |
1998年 | 43篇 |
1997年 | 28篇 |
1996年 | 17篇 |
1995年 | 21篇 |
1994年 | 21篇 |
1993年 | 18篇 |
1992年 | 52篇 |
1991年 | 53篇 |
1990年 | 44篇 |
1989年 | 58篇 |
1988年 | 37篇 |
1987年 | 33篇 |
1986年 | 26篇 |
1985年 | 36篇 |
1984年 | 28篇 |
1983年 | 30篇 |
1982年 | 15篇 |
1981年 | 15篇 |
1980年 | 17篇 |
1979年 | 31篇 |
1978年 | 17篇 |
1977年 | 21篇 |
1974年 | 16篇 |
1972年 | 15篇 |
1970年 | 13篇 |
排序方式: 共有5109条查询结果,搜索用时 31 毫秒
61.
Between January 1995 and Jul 1997, 474 patients with anterior knee pain resistant to conservative treatment were referred
for MR of the knee. The MR examination consisted of routine sequences with an additional patellofemoral dynamic examination
using a technique that has been developed at this institution. The dynamic study examines both knees simultaneously, with
the patient supine and the quadriceps loaded. No gating or restraint apparatus is needed. Patellar subluxation or tilt was
present in 188(40 %) of cases, bilateral in 104 and unilateral in 84 cases (right 39, left 45). It was classified as mild
in 51 %, moderate in 39 % and severe in 10 %. Subluxation was more prevalent in females than males (42 % vs. 37 %) and this
was most obvious in the severe group where 68 % were female. In 90 knees selected at random, four measurements of patellofemoral
morphology were obtained using reconstructed images from a volume gradient echo sequence. These measurements were correlated
with the degree of subluxation or tilt. A tibial tubercle distance greater than 20 mm, a femoral sulcus angle greater than
150 degrees, sulcus depth less than 4 mm were specific for subluxation but no measurement proved to be sufficiently sensitive
to preclude a tracking study. MRI can be used to define more precisely the anatomy of the extensor mechanism and its relationship
to the femur and tibia, in both a static and dynamic setting. In this way, patients with anterior knee pain can be classified
more accurately and the outcomes of treatment more reliably assessed.
Received: 17 September 1999; Revised: 31 January 2000; Accepted: 4 February 2000 相似文献
62.
Samii A Pal PK Schulzer M Mak E Tsui JK 《The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques》2000,27(1):55-59
BACKGROUND/OBJECTIVE: The incidence of head/neck trauma preceding cervical dystonia (CD) has been reported to be 5-21%. There are few reports comparing the clinical characteristics of patients with and without a history of injury. Our aim was to compare the clinical characteristics of idiopathic CD (CD-I) to those with onset precipitated by trauma (CD-T). METHODS: We evaluated 114 consecutive patients with CD over a 9-month period. All patients were interviewed using a detailed questionnaire and had a neurological examination. Their clinical charts were also reviewed. RESULTS: Fourteen patients (12%) had mild head/neck injury within a year preceding the onset of CD. Between the two groups (CD-I and CD-T), the gender distribution (F:M of 3:2), family history of movement disorders (32% vs. 29%), the prevalence of gestes antagonistes (65% vs. 64%), and response to botulinum toxin were similar. There were non-specific trends, including an earlier age of onset (mean ages 43.3 vs. 37.6), higher prevalence of neck pain (86% vs. 100%), head tremor (67% vs. 79%), and dystonia in other body parts (23% vs. 36%) in CD-T. CONCLUSIONS: CD-I and CD-T are clinically similar. Trauma may be a triggering factor in CD but this was only supported by non-significant trends in its earlier age of onset. 相似文献
63.
A K Nag Chaudhuri Sanmoy Karmakar Dilip Roy Siddhartah Pal Mintu Pal Tuhinadri Sen 《Pharmacological research》2005,51(2):169-175
In this study, the anti-inflammatory (in reference to the cardinal signs of inflammation) and other related pharmacological activities of the hot water extract of black tea (Camellia sinensis, Sikkim variety) were evaluated along with certain standard drugs. The extract showed significant inhibitory activity against carrageenin, histamine, serotonin and prostaglandin-induced pedal inflammation. The extract inhibited exudative inflammation. The tea extract also inhibited cotton pellet-induced granuloma formation and adjuvant-induced polyarthritis. Black tea extract showed significant inhibition against glucose oxidase-mediated inflammation. The present observations establish the efficacy of this particular variety of black tea, both in the exudative and proliferative forms and as well in the chronic phase of inflammation. 相似文献
64.
Rimesh Pal Naresh Sachdeva Soham Mukherjee Vikas Suri Deepy Zohmangaihi Sant Ram Goverdhan Dutt Puri Ashish Bhalla Shiv Lal Soni Navin Pandey Anil Bhansali Sanjay Kumar Bhadada 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2021,15(1):193-196
Background and aimsPatients with diabetes mellitus (DM) often demonstrate impaired antibody response to influenza/hepatitis B vaccines. Hence, we compared anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with and without type 2 diabetes mellitus (T2DM).MethodsRecords of non-severe COVID-19 patients admitted at our institution between April 10, 2020 and May 20, 2020 were retrieved. Qualitative detection of total (IgG + IgM) anti-SARS-CoV-2 antibody was performed using electrochemiluminescence immunoassay in plasma samples collected at least 14 days post-polymerase chain reaction (PCR) confirmation of diagnosis.ResultsThirty-one non-severe COVID-19 patients were included. Nine patients (29%) had T2DM with mean HbA1c at admission of 8.3 ± 1.0%. Anti-SARS-CoV-2 antibody was estimated at a median of 16 (14–17) days post-PCR confirmation of COVID-19 diagnosis. Only three patients (10%) were seronegative, and all had T2DM. Patients with T2DM were more likely to have non-detectable anti-SARS-CoV-2 antibodies than those without DM (p = 0.019).ConclusionsCOVID-19 patients with T2DM may not undergo seroconversion even after two weeks of diagnosis. Impaired seroconversion could theoretically increase the risk of reinfections in patients with DM. However, the finding requires validation in large-scale studies involving serial estimations of anti-SARS-CoV-2 antibodies in patients with and without DM. 相似文献
65.
Rune Wilkens Alexandra Wilson Peter N. Burns Subrata Ghosh Stephanie R. Wilson 《Ultrasound in medicine & biology》2018,44(11):2189-2198
A small population of patients with severe Crohn's disease (CD) exhibit atypical lack of intensity decline on intestinal contrast-enhanced ultrasound. From a retrospective CD cohort examined with contrast-enhanced ultrasound, 104 patients were identified. Twenty study patients with severe active disease exhibited high peak enhancement (>23 dB) and minimal decline. From the same cohort, 84 control patients also exhibited high peak enhancement >23dB, but with typical intensity decline. Patient outcomes were assessed. Time–intensity curve analysis revealed a significantly higher (p < 0.0001) area under the curve (44.7 ± 1.5 dB·s), washout time and intensities at 60s and 120s in the study population compared with controls (40.0 ± 1.1 dB·s). Study patients had a worse overall outcome with surgery in 30% versus 10% (p?=?0.027) during follow-up. Heightened enhancement with lack of decline on contrast-enhanced ultrasound suggests microbubbles are stuck within the inflamed bowel wall for an extended period. This observation occurs in patients with severe disease and a bad outcome. 相似文献
66.
67.
68.
69.
Severe sepsis often leads to multiple organ dysfunction syndromes (MODS) with acute kidney injury (AKI). AKI affects approximately, 35% of Intensive Care Unit patients, and most of these are due to sepsis. Mortality rate of sepsis-induced AKI is high. Inappropriate use of antimicrobials may be responsible for higher therapeutic failure, mortality rates, costs and toxicity as well as the emergence of resistance. Antimicrobial treatment is particularly difficult due to altered pharmacokinetic profile, dynamic changes in patient''s clinical status and, in many cases, need for renal replacement therapy. This article aims to describe the appropriate antimicrobial dosing and reviews the factors contributing to the difficulties in establishing precise guidelines for antimicrobial dosing in sepsis-induced AKI patients. Search strategy: Text material was collected by systematic search in PubMed, Google (1978–2013) for original articles. 相似文献
70.