全文获取类型
收费全文 | 638篇 |
免费 | 44篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 27篇 |
妇产科学 | 8篇 |
基础医学 | 74篇 |
口腔科学 | 10篇 |
临床医学 | 63篇 |
内科学 | 156篇 |
皮肤病学 | 18篇 |
神经病学 | 23篇 |
特种医学 | 6篇 |
外科学 | 79篇 |
综合类 | 14篇 |
预防医学 | 53篇 |
眼科学 | 30篇 |
药学 | 51篇 |
中国医学 | 6篇 |
肿瘤学 | 54篇 |
出版年
2023年 | 9篇 |
2022年 | 22篇 |
2021年 | 44篇 |
2020年 | 21篇 |
2019年 | 24篇 |
2018年 | 45篇 |
2017年 | 18篇 |
2016年 | 14篇 |
2015年 | 27篇 |
2014年 | 26篇 |
2013年 | 35篇 |
2012年 | 49篇 |
2011年 | 47篇 |
2010年 | 26篇 |
2009年 | 22篇 |
2008年 | 50篇 |
2007年 | 41篇 |
2006年 | 31篇 |
2005年 | 26篇 |
2004年 | 21篇 |
2003年 | 22篇 |
2002年 | 16篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1989年 | 1篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1962年 | 1篇 |
1961年 | 1篇 |
1943年 | 1篇 |
排序方式: 共有685条查询结果,搜索用时 281 毫秒
21.
Sri Ganesh Skanda Sri Ganesh Ronald Gaster Sheetal Brar 《Indian journal of ophthalmology》2020,68(12):3060
A 24-year-old female underwent small incision lenticule extraction (SMILE) for myopic astigmatism OU. In the left eye, cap-lenticular adhesion along with tearing of the cap occurred, resulting in a gaped incision and transverse striae involving the visual axis on the first post op day. Uncorrected distance visual acuity (UDVA) was 20/32. The case was managed with interface wash and stretching of the cap, in order to iron out the striae. Post intervention, the UDVA improved to 20/20, striae resolved, and interface remained clear through a follow-up of nine months, suggesting that cap striae in SMILE may be similarly managed as the flap striae in laser-assisted in situ keratomileusis (LASIK), resulting in satisfactory visual outcomes. 相似文献
22.
23.
Nelli Giribabu Sri Bhashyam Sainath Pamanji Sreenivasula Reddy 《Environmental toxicology》2014,29(5):534-544
This study was aimed to investigate the reproductive health in adult male rats exposed to di‐n‐butyl phthalate (DBP) during embryonic development. Pregnant rats were injected with DBP and F1 male rats were weaned and on postnatal day 100, used for mating with normal cycling females to assess reproductive performance. After completion of cohabitation period, rats were analyzed for other reproductive end points. Transplacental exposure to DBP significantly decreased fertility in adult male rats. Prenatal exposure to DBP significantly decreased sperm density, number of motile sperms, viable sperms, and hypoosmotic swelling tail coiled sperms with an increase in morphological abnormalities in sperms. Testicular steroidogenic enzyme activity levels and serum testosterone levels were significantly decreased in rats exposed to DBP during embryonic development. In conclusion, transplacental exposure to DBP impairs male reproductive performance by decreasing steroidogenesis and spermatogenesis. © 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 534–544, 2014. 相似文献
24.
Balakrishnan V Unnikrishnan AG Thomas V Choudhuri G Veeraraju P Singh SP Garg P Pai CG Devi RN Bhasin D Jayanthi V Premalatha N Chacko A Kar P Rai RR Rajan R Subhalal N Mehta R Mishra SP Dwivedi M Vinayakumar KR Jain AK Biswas K Mathai S Varghese J Ramesh H Alexander T Philip J Raj VV Vinodkumar A Mukevar S Sawant P Nair P Kumar H Sudhindran S Dhar P Sudheer OV Sundaram KR Tantri BV Singh D Nath TR 《JOP : Journal of the pancreas》2008,9(5):593-600
25.
Sutanto I Supriyanto S Ruckert P Purnomo Maguire JD Bangs MJ 《The American journal of tropical medicine and hygiene》2004,70(5):467-473
The efficacy of chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) was evaluated in 89 subjects greater than one year of age with uncomplicated P. falciparum malaria in the East Nusatenggara Province of Indonesia. Fever clearance time was longer in the SP group than in the CQ group. However, parasite clearance time was extended in subjects who received CQ compared with those who received SP. Major adverse events were not observed in either group, and no hospitalizations were required during the study. Treatment failure rates at day 28 were 69% for CQ and 8.5% for SP. In both treatment groups, gametocytemia developed during the follow-up period, but was more pronounced in the SP group, peaking at 94% on day 7. Regardless of treatment group, children < 10 years of age had significantly higher treatment failure rates than subjects >/=10 years of age (relative risk = 2.49), suggesting that acquired immunity influenced treatment outcomes in the presence of parasite drug resistance. Although a highly effective alternative to CQ for clearing infection, SP treatment also presented some potential drawbacks (e.g., increased and persistent gametocytemia). Replacement of CQ with SP as a first-line therapy, either alone or in combination with CQ, in those areas of Indonesia with high levels of CQ resistance should significantly improve treatment outcomes, particularly in vulnerable populations lacking clinical immunity. More efficacious and rapidly acting asexual stage treatments are generally associated with increased gametocyte clearance and combination therapy in areas where drug resistance is high or emerging may provide an additional means for reducing transmission. 相似文献
26.
27.
Mandar Bopardikar Anusri Bhattacharya Veera Mohana Rao Kakita Kavitha Rachineni Lalit C. Borde Sinjan Choudhary Sri Rama Koti Ainavarapu Ramakrishna V. Hosur 《RSC advances》2019,9(49):28470
The process of assembly and accumulation of the intrinsically disordered protein (IDP), alpha-synuclein (αSyn) into amyloid fibrils is a pathogenic process leading to several neurodegenerative disorders such as Parkinson''s disease, multiple system atrophy and others. Although several molecules are known to inhibit αSyn fibrillization, the mechanism of inhibition is just beginning to emerge. Here, we report the inhibition of fibrillization of αSyn by Triphala, a herbal preparation in the traditional Indian medical system of Ayurveda. Triphala was found to be a rich source of polyphenols which are known to act as amyloid inhibitors. ThT fluorescence and TEM studies showed that Triphala inhibited the fibrillization of αSyn. However, it was observed that Triphala does not disaggregate preformed αSyn fibrils. Further, native-PAGE showed that Triphala reduces the propensity of αSyn to oligomerize during the lag phase of fibrillization. Our NMR results showed that certain stretches of residues in the N-terminal and NAC regions of αSyn play an anchor role in the self-association process of the protein, thereby providing mechanistic insights into the early events during αSyn fibrillization.Triphala inhibits αSyn self-association by interacting with anchoring regions which are responsible for αSyn oligomerization. 相似文献
28.
Loredana Bury Karyn Megy Jonathan C. Stephens Luigi Grassi Daniel Greene Nick Gleadall Karina Althaus David Allsup Tadbir K. Bariana Mariana Bonduel Nora V. Butta Peter Collins Nicola Curry Sri V. V. Deevi Kate Downes Daniel Duarte Kim Elliott Emanuela Falcinelli Bruce Furie David Keeling Michele P. Lambert Rachel Linger Sarah Mangles Rutendo Mapeta Carolyn M. Millar Christopher Penkett David J. Perry Kathleen E. Stirrups Ernest Turro Sarah K. Westbury John Wu NIHR BioResource Keith Gomez Kathleen Freson Willem H. Ouwehand Paolo Gresele Ilenia Simeoni 《Human mutation》2020,41(1):277-290
The heterogeneous manifestations of MYH9‐related disorder (MYH9‐RD), characterized by macrothrombocytopenia, Döhle‐like inclusion bodies in leukocytes, bleeding of variable severity with, in some cases, ear, eye, kidney, and liver involvement, make the diagnosis for these patients still challenging in clinical practice. We collected phenotypic data and analyzed the genetic variants in more than 3,000 patients with a bleeding or platelet disorder. Patients were enrolled in the BRIDGE‐BPD and ThromboGenomics Projects and their samples processed by high throughput sequencing (HTS). We identified 50 patients with a rare variant in MYH9. All patients had macrothrombocytes and all except two had thrombocytopenia. Some degree of bleeding diathesis was reported in 41 of the 50 patients. Eleven patients presented hearing impairment, three renal failure and two elevated liver enzymes. Among the 28 rare variants identified in MYH9, 12 were novel. HTS was instrumental in diagnosing 23 patients (46%). Our results confirm the clinical heterogeneity of MYH9‐RD and show that, in the presence of an unclassified platelet disorder with macrothrombocytes, MYH9‐RD should always be considered. A HTS‐based strategy is a reliable method to reach a conclusive diagnosis of MYH9‐RD in clinical practice. 相似文献
29.
Molecular diversity of HIV‐1 and surveillance of transmitted drug resistance variants among treatment Naïve patients, 5 years after active introduction of HAART in Kuala Lumpur,Malaysia 下载免费PDF全文
30.