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101.
Rosen BR; Fleming DM; Kushner DC; Zaner KS; Buxton RB; Bennet WP; Wismer GL; Brady TJ 《Radiology》1988,169(3):799
102.
H. E. Nielsen P. Saks H. Skovgaard Poulsen C. C. Gadeberg 《Acta oncologica (Stockholm, Sweden)》1985,24(3):247-251
The investigation was carried out to elucidate a possible relationship between the amount of estrogen receptors and bone mineral content in patients with breast tumors. Bone mineral content (BMC) was measured by photon absorptiometry in the distal forearm of 54 women with untreated breast carcinoma and 19 with benign breast tumor. The concentration of unoccupied high affinity estrogen receptors was measured in breast tumor biopsy specimens. Higher values of BMC were found in the total group of estrogen receptor-positive patients with breast carcinoma compared with estrogen receptor-negative patients, but not after dividing the patients into smaller groups according to age. No significant correlation could be seen between the amount of estrogen receptors and bone mineral content. In conclusion the present study could not support a relationship between the amount of estrogen receptors in breast cancer tissue and the amount of bone mineral and bone mass in women with breast tumors. 相似文献
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The CT appearance of the adrenal glands was investigated in 30 patients with congenital renal anomalies (17 cases of unilateral renal agenesis, 11 of inferior ectopy, and 2 of crossed fused ectopy). The ipsilateral adrenal was clearly identified in 83% of these patients; in all of them, the adrenal was a paraspinal disk-shaped organ, which appeared linear on CT. Conversely, the adrenals retained their normal shape in a control group of 20 patients with acquired renal atrophy or prior simple nephrectomy. 相似文献
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常咯啉在实验性心律失常狗的药代动力学-药效动力学分析 总被引:1,自引:0,他引:1
用Harris冠脉结扎法诱发的心律失常狗研究常咯啉药代动力学-药效动力学。7只狗按83.33μg·kg ̄(-1)·min ̄(-1)静脉滴注60min,在给药期间和停药后不同时间记录ECG及测定血药浓度。C-T数据用药代程序计算药代参数;药效数据用药代-药效同步分析模型计算药效动力学参数,K10,T1/2,Vd,Cl分别为0.0087min ̄(-1),78.03min,40.55ml·kg ̄(-1)和0.421ml·kg ̄(-1)·min ̄(-1);Ke0和Ce(50)分别为0.0048min ̄(-1)和2.01μg·ml ̄(-1). 相似文献
109.
A 72-year-old Danish puzzle resolved--comparative analysis of phenotypes in families with different-sized HOXD13 polyalanine expansions 总被引:11,自引:0,他引:11
Kjaer KW Hansen L Eiberg H Utkus A Skovgaard LT Leicht P Opitz JM Tommerup N 《American journal of medical genetics. Part A》2005,138(4):328-339
A phenotype-genotype correlation was previously described for carriers of different sized of polyalanine expansions in HOXD13. We report on a detailed comparison of 55 members (approximately 220 limbs) from 4 Danish families with duplications of 21 or 27 bp, expanding the polyalanine repeat from 15 to 22 and 24 residues, respectively. Two of these were previously described by Danish pioneers of human genetics, Tage Kemp and Oluf Thomsen. A clinical score was assigned to each limb based on manifestations assumed to represent different degrees of a duplication defect in hand rays 3-4 and foot rays 4-5. The length of metacarpals and phalangeal bones in rays 1, 2, and 5 was measured on hand radiographs and converted to Z-scores. The relative difference between corresponding right and left bones and directional, total, and fluctuating asymmetry was calculated for each individual. All of these parameters were compared between carriers of the +9 alanine expansion, the +7 alanine expansion, and non-mutation carriers with affected parents from the two families. Upper limb scores and the rate of abnormal bones (>2SD) were significantly higher in the first group than in the others. The first metacarpal and the middle phalanx of the little finger were significantly shorter, and the proximal phalanx of the index finger was significantly longer in this group than in the others. An increased level of total and fluctuating asymmetry was observed in long expansion carriers. Thus, our data have added evidence to the phenotype-genotype correlation previously reported, which was further extended to include lesser involvement of bones in ray 1, 2, and 5. 相似文献
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