全文获取类型
收费全文 | 8629篇 |
免费 | 686篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 171篇 |
儿科学 | 404篇 |
妇产科学 | 223篇 |
基础医学 | 986篇 |
口腔科学 | 234篇 |
临床医学 | 691篇 |
内科学 | 2195篇 |
皮肤病学 | 275篇 |
神经病学 | 573篇 |
特种医学 | 300篇 |
外科学 | 1488篇 |
综合类 | 61篇 |
一般理论 | 2篇 |
预防医学 | 728篇 |
眼科学 | 194篇 |
药学 | 406篇 |
中国医学 | 34篇 |
肿瘤学 | 376篇 |
出版年
2023年 | 36篇 |
2022年 | 79篇 |
2021年 | 225篇 |
2020年 | 125篇 |
2019年 | 288篇 |
2018年 | 280篇 |
2017年 | 206篇 |
2016年 | 215篇 |
2015年 | 220篇 |
2014年 | 309篇 |
2013年 | 392篇 |
2012年 | 437篇 |
2011年 | 520篇 |
2010年 | 363篇 |
2009年 | 280篇 |
2008年 | 408篇 |
2007年 | 460篇 |
2006年 | 469篇 |
2005年 | 433篇 |
2004年 | 386篇 |
2003年 | 374篇 |
2002年 | 363篇 |
2001年 | 313篇 |
2000年 | 364篇 |
1999年 | 268篇 |
1998年 | 100篇 |
1997年 | 80篇 |
1996年 | 69篇 |
1995年 | 60篇 |
1994年 | 53篇 |
1993年 | 48篇 |
1992年 | 138篇 |
1991年 | 121篇 |
1990年 | 105篇 |
1989年 | 104篇 |
1988年 | 60篇 |
1987年 | 59篇 |
1986年 | 50篇 |
1985年 | 61篇 |
1984年 | 36篇 |
1983年 | 35篇 |
1982年 | 20篇 |
1981年 | 20篇 |
1980年 | 21篇 |
1979年 | 27篇 |
1975年 | 22篇 |
1973年 | 24篇 |
1972年 | 22篇 |
1971年 | 21篇 |
1969年 | 22篇 |
排序方式: 共有9341条查询结果,搜索用时 0 毫秒
991.
R Ruiz Granell A Querchfeld R García Civera L D Insa Pérez J Sanchis Fores S M Martínez-Curt S Morell Cabedo R Sanjuán Má?ez V López Merino 《Revista espa?ola de cardiología》1990,43(5):293-299
Ventricular arrhythmias detected in the late-hospital phase of myocardial infarction have been identified as a risk factor for sudden death, being their prognostic value independent of ventricular function. However, relations between both factors are not clarified. In order to study hypothetic associations between ventricular arrhythmias and some clinical, hemodynamic and angiographic variables, 60 patients (52 males, 8 females) underwent 24-hour Holter recordings and cardiac catheterization with left ventricular and coronary angiographies, 3-5 weeks after hospital admission. Past history data, acute phase complications and hemodynamic and angiographic results were compared between patients with and without significant ventricular arrhythmias during Holter monitoring (10 or more PVC's/hour and/or repetitive forms). No significant differences were found between both groups neither in mean age nor in the incidence of previous angina or infarction, cerebral ischemia, diabetes, lipid disorders or subjective feeling of being under psychological stress. Prior history of arterial hypertension was, however, significantly more frequent in patients with ventricular arrhythmias (53.3% vs 17.8%; p = 0.0183). No differences were observed in the localization of the infarct or in the complications during the acute phase (CPK peak, Killip's score, angina after 24 hours of evolution, intraventricular or A-V conduction disorders and supraventricular and ventricular arrhythmias). Among hemodynamic data, only left ventricular and aortic systolic pressures were different in both groups, being significantly higher in patients with ventricular arrhythmias. There were not differences in left ventricular segmentary contraction and in number of coronary vessels involved. To conclude, significant ventricular arrhythmias were recorded in 25% of patients.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
992.
993.
994.
Management of the perineal wound following abdominoperineal resection: prospective study of three methods. 总被引:8,自引:0,他引:8
R Robles Campos J Garcia Ayllon P Parrila Paricio J Cifuentes Tebar J A Lujan Mompean R Liron Ruiz J A Torralba Martinez J Molina Martinez 《The British journal of surgery》1992,79(1):29-31
A prospective study was made of three procedures for treating the perineal wound and presacral cavity in 102 patients undergoing abdominoperineal excision for cancer of the rectum: (1) packing of the presacral space after suture of the pelvic peritoneum; (2) suture of the pelvic peritoneum and perineal wound, leaving two drains through the perineum; and (3) no suture of the pelvic peritoneum, and primary closure of the perineal wound, leaving drains through the abdomen for physiological saline irrigation. The parameters analysed were incidence of infection, primary healing of the perineum, extraperineal complications and mean hospital stay. Primary healing of the perineum was best with method 3, and overall incidence of infection highest with method 2. There were no differences between the methods with regard to extraperineal complications. Hospital stay was shortest with method 3. 相似文献
995.
F Ruiz Montes J M Re?é Espinet M Rubio Caballero 《Revista española de enfermedades digestivas》1992,81(4):270-279
We review the Spanish literature on Eosinophilic Gastroenteritis. The data are compared with those of several foreign series. Abdominal pain, vomiting, diarrhea, and abdominal distension due to ascites were the most frequent clinical manifestations. In our country most cases had ascites. A history of allergy was reported by less than on half of patients. Peripheral eosinophilia with otherwise normal laboratory findings is the rule. However, peripheral eosinophilia was not essential for diagnosis, since it was absent in one quarter of patients. Small intestine barium studies were abnormal almost always, but the findings were not specific. The diagnosis is based on the endoscopic and/or peroral gastrointestinal biopsy. However, a false negative diagnosis can occur, since the disease can take up a patchy distribution, or a more profound involvement of the gastrointestinal layers without mucosal disease. The treatment of choice is corticosteroids, with a spectacular therapeutic response. Complete studies with biopsies taken at multiple levels of the gastrointestinal tract, are necessary to ascertain the extent and depth of the disease. The etiology is unknown, and although allergy causes can be elicited in some cases, they are absent in the majority of them. We encounter no essential differences in the eosinophilic gastroenteritis characteristics in our country in relation to other countries. 相似文献
996.
Pedro A. López González Pedro López Cubillana Antonio Prieto González Ana I. López López José C. Ruiz Morcillo Mariano Pérez Albacete 《Actas urologicas espa?olas》2009,33(9):976-981
ObjectiveTo report our series of patients undergoing hand-assisted laparoscopic nephroureterectomy (HALNU) using the pluck-off procedure.Materials and methodsTwenty patient undergoing HALMU for upper urinary tract urothelial tumors from November 2002 to December 2007 were assessed. Demographic, clinical, surgical, and oncological data were assessed.ResultsMean patient age was 69 years. Mean operating time and mean intraoperative bleeding were 176 min and 381 mL respectively. Twenty percent of patients required transfusion of blood products. Conversion to open surgery was not required in any patient.Major and minor complications occurred in 25% and 30% of patients respectively.Mean time to oral intake was 48 hours, and mean hospital stay was 5 days.Pathological study revealed transitional cell carcinoma in all cases: grade I in 5%, grade II in 60%, and grade III in 35% of patients. Clinical stage was pTa in 5%, pT1 in 20%, pT2 in 25%, pT3 in 40%, and pT4 in 10% of patients.A bladder recurrence rate of 30% and a 49% overall survival were seen after a mean followup of 33 months (5-73). Six-year cancer-specific survival was 67%. No patient developed either peritoneal or surgical bed recurrence.ConclusionsHALMU using the pluck-off procedure is a feasible, safe, and effective surgery. Both surgical and oncological results are similar to those of open surgery and pure laparoscopy. 相似文献
997.
998.
999.
New diseases derived or associated with the tight junction 总被引:1,自引:0,他引:1
Cereijido M Contreras RG Flores-Benítez D Flores-Maldonado C Larre I Ruiz A Shoshani L 《Archives of medical research》2007,38(5):465-478
The space between neighboring epithelial cells is sealed by the tight junction (TJ). When this seal is leaky, such as in the proximal tubule of the kidney or the gallbladder, substances may cross the epithelium between the cells (paracellular pathway). Yet, when TJs are really hermetic, as is the case in the epithelium of the urinary bladder or the colon, substances can mainly cross the epithelium through the transcellular pathway. The structure of the TJ involves (so far) some 50-odd protein species. Failure of any of these components causes a variety of diseases, some of them so serious that fetuses are not viable. A fast-growing number of diseases are recognized to depend or involve alterations in the TJ. These include autoimmune diseases, in which intestinal TJs allow the passage of antigens from the intestinal flora, challenging the immune system to produce antibodies that may cross react with proteins in the brain, thyroid gland or pancreas. TJs are also involved in cancer development, infections, allergies, etc. The present article does not catalogue all TJ diseases known so far, but describes one of each type as illustration. It also depicts the efforts being made to find pharmaceutical agents that would seal faulty TJs or release their grip to allow for the passage of large molecules through the upper respiratory and digestive tracts, such as insulin, thyroid, appetite-regulatory peptide, etc. 相似文献
1000.
Ochoa-Callejero L Berraondo P Crettaz J Olagüe C Vales A Ruiz J Prieto J Tennant BC Menne S González-Aseguinolaza G 《Journal of medical virology》2007,79(5):522-529
Woodchucks infected with the woodchuck hepatitis virus (WHV) is the best available animal model for testing the immunotherapeutic effects of dendritic cells (DCs) in the setting of a chronic infection, as woodchucks develop a persistent infection resembling that seen in humans infected with the hepatitis B virus. In the present study, DCs were generated from woodchuck peripheral blood mononuclear cells (wDCs) in the presence of human granulocyte macrophage colony-stimulating factor (hGM-CSF) and human interleukin 4 (hIL-4). After 7 days of culture, cells with morphology similar to DCs were stained positively with a cross-reactive anti-human CD86 antibody. Functional analysis showed that uptake of FITC-dextran by wDCs was very efficient and was partially inhibited after LPS-induced maturation. Furthermore, wDCs stimulated allogenic lymphocytes and induced proliferation. Moreover, wDCs were transduced efficiently with a human adenovirus serotype 5 for the expression of beta-galactosidase. Following transduction and in vivo administration of such DCs into woodchucks, an antigen-specific cellular immune response was induced. These results demonstrate that wDCs can be generated from the peripheral blood. Following transfection with a recombinant adenovirus wDCs can be used as a feasible and effective tool for eliciting WHV-specific T-cell responses indicating their potential to serve as prophylactic and therapeutic vaccines. 相似文献