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Laura M. J. de F. Santos Maria Cecília F. Damé Beatris G. Cademartori Nilton A. da Cunha Filho Nara Amélia da R. Farias Jerônimo L. Ruas 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2013,58(3):334-336
Serum samples from 169 water buffaloes and 121 beef cattle were analyzed for antibodies to T. gondii by an indirect fluorescent antibody test (IFAT). Positive results were obtained in 27.2% of water buffaloes and 17.4% of cattle. Statistical analysis indicated significant differences between the prevalence in cattle and buffalo (p ≤ 0.05). The highest titres found in positive animals were 1:256 (buffaloes) and 1:64 (cattle). In both bovine species, toxoplasmosis frequency in young animals (less than 2 years old) was lower compared to older individuals, although the differences seen in cattle were not statistically significant. 相似文献
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Thaís dos Santos Fontes Pereira DDS MSc Fernanda Cristina Melo Pelinsari DDS Bruna Mara Ruas DDS Luanne Priscila Pereira Avelar DDS Vitor José da Fonseca DDS Mauro Henrique Nogueira de Abreu DDS PhD Ulisses Eliezer Salomão DDS MSc Agnaldo Soares Lima MD PhD Maria Elisa de Souza e Silva DDS PhD Ricardo Santiago Gomez DDS PhD 《Special care in dentistry》2016,36(5):277-281
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James P. White Christiane D. Wrann Rajesh R. Rao Sreekumaran K. Nair Mark P. Jedrychowski Jae-Sung You Vicente Martínez-Redondo Steven P. Gygi Jorge L. Ruas Troy A. Hornberger Zhidan Wu David J. Glass Xianhua Piao Bruce M. Spiegelman 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(44):15756-15761
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Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity
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Bernardes ES Silva NM Ruas LP Mineo JR Loyola AM Hsu DK Liu FT Chammas R Roque-Barreira MC 《The American journal of pathology》2006,168(6):1910-1920
In attempts to investigate the role of galectin-3 in innate immunity, we studied galectin-3-deficient (gal3-/-) mice with regard to their response to Toxoplasma gondii infection, which is characterized by inflammation in affected organs, Th-1-polarized immune response, and accumulation of cysts in the central nervous system. In wild-type (gal3+/+) mice, infected orally, galectin-3 was highly expressed in the leukocytes infiltrating the intestines, liver, lungs, and brain. Compared with gal3+/+, infected gal3-/- mice developed reduced inflammatory response in all of these organs but the lungs. Brain of gal3-/- mice displayed a significantly reduced number of infiltrating monocytes/macrophages and CD8+ cells and a higher parasite burden. Furthermore, gal3-/- mice mounted a higher Th1-polarized response and had comparable survival rates on peroral T. gondii infection, even though they were more susceptible to intraperitoneal infection. Interestingly, splenic cells and purified CD11c+ dendritic cells from gal3-/- mice produced higher amounts of interleukin-12 than cells from gal3+/+ mice, possibly explaining the higher Th1 response verified in the gal3-/- mice. We conclude that galectin-3 exerts an important role in innate immunity, including not only a pro-inflammatory effect but also a regulatory role on dendritic cells, capable of interfering in the adaptive immune response. 相似文献
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