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121.
Buciuc Marina Whitwell Jennifer L. Boeve Bradley F. Ferman Tanis J. Graff-Radford Jonathan Savica Rodolfo Kantarci Kejal Fields Julie A. Knopman David S. Petersen Ronald C. Parisi Joseph E. Murray Melissa E. Dickson Dennis W. Josephs Keith A. 《Journal of neurology》2020,267(5):1444-1453
Journal of Neurology - Trans-active response DNA-binding protein of 43 kDa (TDP-43) can be detected in up to 63% of autopsy-confirmed Lewy body disease (LBD) cases. It is unclear whether... 相似文献
122.
Mario Amore Cecchini Maria Paula Foss Vitor Tumas Flávia A.P. Patrocinio Rodolfo D. Chiari-Correia Nathalia Novaretti Tamara R. Brozinga Valéria Santoro Bahia Leonardo Cruz de Souza Henrique Cerqueira Guimarães Paulo Caramelli Thais Bento Lima-Silva Luciana Cassimiro Sonia Maria Dozzi Brucki Ricardo Nitrini Sergio Della Sala Mario A. Parra Mônica Sanches Yassuda 《International journal of geriatric psychiatry》2020,35(11):1331-1340
123.
Gabriel López-Ramírez Rodolfo Sánchez-Zavaleta Arturo Ávalos-Fuentes Juan José Sierra Francisco Paz-Bermúdez Gerardo Leyva-Gómez José Segovia Vila Hernán Cortés Benjamín Florán 《Synapse (New York, N.Y.)》2020,74(3):e22139
CB2 receptors (CB2R) are expressed in midbrain neurons. To evidence the control of dopamine release in dorsal striatum by CB2R, we performed experiments of [3H]-dopamine release in dorsal striatal slices. We found a paradoxical increase in K+-induced [3H]-dopamine release by CB2R activation with GW 833972A and JWH 133 two selective agonist. To understand the mechanism involved, we tested for a role of the D2 autoreceptor in this effect; because in pallidal structures, the inhibitory effect of CB1 receptors (CB1R) on GABA release is switched to a stimulatory effect by D2 receptors (D2R). We found that the blockade of D2 autoreceptors with sulpiride prevented the stimulatory effect of CB2R activation; in fact, under this condition, CB2R decreased dopamine release, indicating the role of the D2 autoreceptor in the paradoxical increase. We also found that the effect occurs in nigrostriatal terminals, since lesions with 6-OH dopamine in the middle forebrain bundle prevented CB2R effects on release. In addition, D2–CB2R interaction promoted cAMP accumulation, and the increase in [3H]-dopamine release was prevented by PKA blockade. D2–CB2R coprecipitation and proximity ligation assay studies indicated a close interaction of receptors that could participate in the observed effects. Finally, intrastriatal injection of CB2R agonist induced contralateral turning in amphetamine-treated rats, which was prevented by sulpiride, indicating the role of the interaction in motor behavior. Thus, these data indicate that the D2 autoreceptor switches, from inhibitory to stimulatory, the CB2R effects on dopamine release, involving the cAMP → PKA pathway in nigrostriatal terminals. 相似文献
124.
Claudia Espinosa‐García Claudia Erika Fuentes‐Venado Christian Guerra‐Araiza Julia Segura‐Uribe Edwin Chvez‐Gutirrez Eunice Dalet Farfn‐García Norma Anglica Estrada Cruz Rodolfo Pinto‐Almazn 《The European journal of neuroscience》2020,52(1):2724-2736
The metabolic syndrome includes changes in blood glucose levels, arterial hypertension, triglycerides, dyslipidemia and central obesity. Countless reports have described the correlation between the metabolic syndrome and cognitive impairment. However, only a few reports have assessed cognitive impairment associated with the metabolic syndrome in animals of both sexes. For this purpose, Sprague‐Dawley male and female rats were fed either with a hypercaloric diet as model of the metabolic syndrome or with a standard chow diet as controls. Subsequently, spatial learning and memory (Morris water maze) as well as short‐ and long‐term memory (passive avoidance task) were evaluated. Body weight, blood pressure, triglycerides, and total cholesterol significantly increased (F(1, 36) = 94.89, p < .001) in rats fed with hypercaloric diet compared to control rats. Furthermore, cognitive impairment was observed in spatial learning and spatial memory on male rats but not on female rats fed with hypercaloric diet. In addition, a long‐term memory impairment was observed in both groups fed with hypercaloric diet in comparison to their respective control group (F(1, 32) = 10.61, p = .0027). Immunohistochemistry results showed no changes in the number of positive cells for NeuN, GFAP and Ox‐42. In males fed with a hypercaloric diet, a decrease in testosterone levels was observed, whereas estradiol levels decreased in females when compared with their respective control group (p < .0001). In this MetS animal model, metabolic and cognitive differences were observed in males and females, which demonstrates that sex hormones play a significant role in metabolic regulation and neuroprotection related to the CA1 region of the hippocampus. 相似文献
125.
Vincenzo Solfrizzi Emanuele Scafato Madia Lozupone Davide Seripa Michele Giannini Rodolfo Sardone Caterina Bonfiglio Daniela I. Abbrescia Lucia Galluzzo Claudia Gandin Marzia Baldereschi Antonio Di Carlo Domenico Inzitari Antonio Daniele Carlo Sabbà Giancarlo Logroscino Francesco Panza 《The American journal of geriatric psychiatry》2017,25(11):1236-1248
126.
Reading errors in patients with cerebellar vermis lesions 总被引:2,自引:0,他引:2
Dyslexia, both developmental and acquired, has been considered the result of cerebrocortical dysfunction, affecting the temporo-parieto-occipital
brain regions. However, dyslexia may involve abnormalities of the magnocellular component of the visual system, leading to
binocular instability or alterations of accommodation. To test the hypothesis of cerebellar involvement in the reading process
– justified by its emergent role in language and cognition – we studied 10 patients with cerebellar vermis/paravermis lesions
using reading tests and we compared the results with those produced by 10 normal volunteers. The data obtained demonstrate
an increased number of reading mistakes in the patient group, resulting from a possible alteration of the diffuse connection
system from the cerebellum to different cerebrocortical and subcortical structures. Acquired dyslexia due to cerebellar impairment
may be due to oculomotor alteration or, more subtly, to the intimate cerebellar-encephalic projections, connecting the cerebellum
to the attentive and alerting processes and to the language system. We discuss the data with an overview of literature.
Received: 22 May 2001, Received in revised form: 14 September 2001, Accepted: 25 September 2001 相似文献
127.
Ringer Ariana Ruffino Juan Pablo Leiva Rodolfo Cuadranti Nadia Argento María Cecilia Martínez María Florencia Rolla Ignacio Chulibert Serenela Carbone Daniela Palatnik Mariano Cortese Maria Noel Lagrutta Mariana Córdoba Laura González Florencia Belén Pacini María Florencia Villar Silvina Raquel Águila Damian Bottasso Oscar Adelmo Pérez Ana Rosa Abdala Marcelo 《Clinical rheumatology》2021,40(7):2955-2963
Clinical Rheumatology - Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with rheumatic... 相似文献
128.
Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm‐aging” 下载免费PDF全文
Marcello Pinti Elisa Cevenini Milena Nasi Sara De Biasi Stefano Salvioli Daniela Monti Stefania Benatti Lara Gibellini Rodolfo Cotichini Maria Antonietta Stazi Tommaso Trenti Claudio Franceschi Andrea Cossarizza 《European journal of immunology》2014,44(5):1552-1562
Mitochondrial components, including mitochondrial DNA (mtDNA), when released extracellularly, can act as “damage‐associated molecular pattern” (DAMP) agents and cause inflammation. As many elderly people are characterized by a low‐grade, chronic inflammatory status defined “inflamm‐aging,” we evaluated if circulating mtDNA can contribute to this phenomenon. Eight hundred and thirty‐one Caucasian subjects were enrolled in the study, including 429 siblings aged 90–104 (90+ siblings). mtDNA plasma levels increased gradually after the fifth decade of life. In 90+ subjects, mtDNA values of two members of the same sibling relationship were directly correlated, suggesting a role for familiar/genetic background in controlling the levels of circulating mtDNA. The subjects with the highest mtDNA plasma levels had the highest amounts of TNF‐α, IL‐6, RANTES, and IL‐1ra; the subjects with the lowest mtDNA levels had the lowest levels of the same cytokines. In vitro stimulation of monocytes with mtDNA concentrations similar to the highest levels observed in vivo resulted in an increased production of TNF‐α, suggesting that mtDNA can modulate the production of proinflammatory cytokines. Our findings therefore show that circulating mtDNA increases with age, and can significantly contribute to the maintenance of the low‐grade, chronic inflammation observed in elderly people. 相似文献
129.
Ruben Marroquin-Segura Maurilio Flores-Pimentel Rodolfo Carreón-Sánchez Martha M. Garcia-Burciaga José Luis Alfredo Mora-Guevara Abigail Aguilar-Contreras Vicente Jesús Hernandez-Abad 《Journal of ethnopharmacology》2009
Aims of study
Despite the ethnopharmacological relevance of Helietta parvifolia A. Gray (Rutaceae) in Mexico, we found no significant pharmacological studies of this plant in the scientific literature. The aim of the present study was to establish the anti-inflammatory effect of an aqueous extract of the stem bark of Helietta parvifolia in mice.Materials and methods
The anti-inflammatory activity of the aqueous extract of the stem bark of Helietta parvifolia was evaluated using carrageenan-induced paw oedema in mice, and the cotton pellet granuloma method.Results
An extract dose ranging from 20 to 80 mg/kg p.o. showed a non-significant effect over the initial phase of carrageenan-induced oedema. However, it showed a significant inhibition of oedema after 3 h, which can be related to the inhibition of the release of kinin-like substances. An ID50 value of 47.4 mg/kg was obtained for the plant extract. The extract also suppressed granulomatous tissue formation during chronic inflammation. The inhibitory values were 19.2, and 22.2, corresponding to 40 and 80 mg/kg doses of extract respectively.Conclusions
Aqueous extract showed a statistically significant anti-inflammatory effect in mice during the late phase of acute inflammation and during chronic inflammation. However, the exact mechanism(s) of anti-inflammatory effects of Helietta parvifolia observed in this study remains unclear. 相似文献130.
Melanoma risk alleles are associated with downregulation of the MTAP gene and hypermethylation of a CpG island upstream of the gene in dermal fibroblasts 下载免费PDF全文
Antonella Sangalli Giovanni Malerba Gianpaolo Tessari Monica Rodolfo Macarena Gomez‐Lira 《Experimental dermatology》2017,26(8):733-736
Several association studies and GWAS on melanoma skin cancer risk have reported statistically significant signals on 9p21.3 region, where MTAP gene maps. None of the associated SNPs identified in these studies lie in the coding region of the gene and the causative relation of risk alleles with melanoma predisposition has not been elucidated. MTAP has a tumor suppressor activity and epigenetic silencing has been described in melanoma cell lines. In the present study, we show that melanoma risk alleles correlate with a MTAP allele‐specific hyper‐methylation and down‐regulation of gene expression. 相似文献