Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

Background  

Abacavir (ABC) treatment has been associated with an increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in HIV-infected patients using antiretroviral therapy with or without ABC were examined to pinpoint a pathogenic mechanism. Given the important role of high sensitivity C-reactive protein (hsCRP) levels in predicting cardiovascular risk, patient groups were also analyzed according to hsCRP levels.     

盐酸多赛平治疗神经性皮炎35例

1临床资料2004-04/12收治神经性皮炎35(男18,女17)例;年龄18～65(39.1±12.1)岁;病程2 mo～9 a平均(1.6±0.3) a.近1 wk内未外用皮质类固醇、抗组胺等药物.所有入选病例均符合赵辨主编的<临床皮肤学>(江苏科技出版社,2001年第3版)有关神经性皮炎的诊断标准.     

The Impact of Using Different Methods to Assess Completeness of 24‐Hour Urine Collection on Estimating Dietary Sodium

The standard for population‐based surveillance of dietary sodium intake is 24‐hour urine testing; however, this may be affected by incomplete urine collection. The impact of different indirect methods of assessing completeness of collection on estimated sodium ingestion has not been established. The authors enlisted 507 participants from an existing community study in 2009 to collect 24‐hour urine samples. Several methods of assessing completeness of urine collection were tested. Mean sodium intake varied between 3648 mg/24 h and 7210 mg/24 h depending on the method used. Excluding urine samples collected for longer or shorter than 24 hours increased the estimated urine sodium excretion, even when corrections for the variation in timed collections were applied. Until an accurate method of indirectly assessing completeness of urine collection is identified, the gold standard of administering para‐aminobenzoic acid is recommended. Efforts to ensure participants collect complete urine samples are also warranted.