全文获取类型
收费全文 | 974篇 |
免费 | 95篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 48篇 |
妇产科学 | 32篇 |
基础医学 | 124篇 |
口腔科学 | 42篇 |
临床医学 | 116篇 |
内科学 | 173篇 |
皮肤病学 | 23篇 |
神经病学 | 51篇 |
特种医学 | 27篇 |
外科学 | 82篇 |
综合类 | 22篇 |
预防医学 | 59篇 |
眼科学 | 60篇 |
药学 | 116篇 |
中国医学 | 9篇 |
肿瘤学 | 82篇 |
出版年
2024年 | 3篇 |
2023年 | 22篇 |
2022年 | 59篇 |
2021年 | 109篇 |
2020年 | 43篇 |
2019年 | 68篇 |
2018年 | 67篇 |
2017年 | 63篇 |
2016年 | 66篇 |
2015年 | 67篇 |
2014年 | 92篇 |
2013年 | 74篇 |
2012年 | 92篇 |
2011年 | 73篇 |
2010年 | 41篇 |
2009年 | 21篇 |
2008年 | 29篇 |
2007年 | 26篇 |
2006年 | 17篇 |
2005年 | 15篇 |
2004年 | 8篇 |
2003年 | 7篇 |
2002年 | 6篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1991年 | 2篇 |
1989年 | 1篇 |
排序方式: 共有1074条查询结果,搜索用时 187 毫秒
51.
52.
Joseph Song Priyanka Kadaba Amanda Kravitz Adilia Hormigo Joshua Friedman Puneet Belani Constantinos Hadjipanayis Benjamin M Ellingson Kambiz Nael 《Neuro-oncology》2020,22(11):1658
BackgroundPhysiologic changes quantified by diffusion and perfusion MRI have shown utility in predicting treatment response in glioblastoma (GBM) patients treated with cytotoxic therapies. We aimed to investigate whether quantitative changes in diffusion and perfusion after treatment by immune checkpoint inhibitors (ICIs) would determine 6-month progression-free survival (PFS6) in patients with recurrent GBM.MethodsInclusion criteria for this retrospective study were: (i) diagnosis of recurrent GBM treated with ICIs and (ii) availability of diffusion and perfusion in pre and post ICI MRI (iii) at ≥6 months follow-up from treatment. After co-registration, mean values of the relative apparent diffusion coefficient (rADC), Ktrans (volume transfer constant), Ve (extravascular extracellular space volume) and Vp (plasma volume), and relative cerebral blood volume (rCBV) were calculated from a volume-of-interest of the enhancing tumor. Final assignment of stable/improved versus progressive disease was determined on 6-month follow-up using modified Response Assessment in Neuro-Oncology criteria.ResultsOut of 19 patients who met inclusion criteria and follow-up (mean ± SD: 7.8 ± 1.4 mo), 12 were determined to have tumor progression, while 7 had treatment response after 6 months of ICI treatment. Only interval change of rADC was suggestive of treatment response. Patients with treatment response (6/7: 86%) had interval increased rADC, while 11/12 (92%) with tumor progression had decreased rADC (P = 0.001). Interval change in rCBV, Ktrans, Vp, and Ve were not indicative of treatment response within 6 months.ConclusionsIn patients with recurrent GBM, interval change in rADC is promising in assessing treatment response versus progression within the first 6 months following ICI treatment.Key Points• In recurrent GBM treated with ICIs, interval change in rADC suggests early treatment response.• Interval change in rADC can be used as an imaging biomarker to determine PFS6.• Interval change in MR perfusion and permeability measures do not suggest ICI treatment response. 相似文献
53.
54.
55.
56.
57.
Systemic inflammatory response syndrome in acute‐on‐chronic liver failure: Relevance of ‘golden window’: A prospective study
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ashok Choudhury Manoj Kumar Barjesh C Sharma Rakhi Maiwall Viniyendra Pamecha Richard Moreau Yogesh K Chawla Ajay Duseja Mamun Mahtab Salimur Rahman Saeed S Hamid Amna S Butt Wasim Jafri Seok Siam Tan Harshad Devarbhavi Deepak Amarapurkar Qin Ning C E Eapen Ashish Goel Dong J Kim Hasmik Ghazinyan Gamal Shiha Guan H Lee Zaigham Abbas Diana A Payawal A Kadir Dokmeci Man‐Fung Yuen Laurentius A Lesmana Ajit Sood Albert Chan George K Lau Ji Dong Jia Zhongping Duan Chen Yu Osamu Yokosuka Priyanka Jain Ajeet S Bhadoria Guresh Kumar Shiv K Sarin for the APASL ACLF working party 《Journal of gastroenterology and hepatology》2017,32(12):1989-1997
58.
Pradyumna Kumar Mishra Venkata Raghuram Gorantla Nabila Akhtar Priyanka Tamrakar Subodh Kumar Jain Kewal Krishan Maudar 《Environmental and molecular mutagenesis》2009,50(4):328-336
Isocyanates (R? N?C?O), one of the highly reactive industrial intermediates, possess the capability to modulate the bio‐molecules by forming toxic metabolites and adducts which may cause adverse health effects. Some of their toxic degradations have previously been unknown and overlooked; of which, molecular repercussions underlying their genetic hazards upon occupational/accidental exposures still remain as an intricate issue and are hitherto unknown. To assess the genotoxic potential of methyl isocyanate in cultured mammalian cells after in vitro exposure, we performed a study in three different normal cell lines MM55.K (mouse kidney epithelial), B/CMBA.Ov (mouse ovarian epithelial), and NIH/3T3 (primary mouse embryonic fibroblast). Cellular DNA damage response was studied for qualitative phosphorylation states of ATM, γH2AX proteins and quantitative state of p53 phosphorylation; DNA cell cycle analysis and measure of cellular apoptotic index before and after treatment were also investigated. Our results demonstrate that methyl isocyanate by negatively regulating the DNA damage response pathway, might promote cell cycle arrest, and apoptosis in cultured mammalian cells suggestive of causing genetic alterations. We anticipate that these data along with other studies reported in the literature would help to design better approaches in risk assessment of occupational and accidental exposure to isocyanates. We also predict that increasing knowledge on DNA damage‐triggered signaling leading to cell death could provide new strategies for investigating the effects of DNA repair disorders and decreased repair capacity on the toxicity and carcinogenic properties of environmental toxins. Environ. Mol. Mutagen., 2009. © 2009 Wiley‐Liss, Inc. 相似文献
59.
Souvik Roy Santanu Sannigrahi Balaram Ghosh Priyanka Pusp Tathagata Roy 《European journal of pharmacology》2013,698(1-3):444-454
The inclusion of antioxidant for the treatment of arthritis, especially under the therapy with immunosuppressant, is motivated because antioxidant plays an essential role in disease progression and moreover, immunosuppressive treatment suffers redox homeostasis balance of the organism. The aim of the present study was to evaluate the enhancement of anti-arthritic effect of dexamethasone in combination with epigallocatechin on the progression of adjuvant-induced arthritis in rats. Adjuvant arthritic rats were treated with dexamethasone (0.2 mg/kg), epigallocatechin (100 mg/kg) and combination of dexamethasone (0.1 mg/kg) with epigallocatechin (100 mg/kg) daily for a period of 28 days. Paw swelling changes, estimation of serum albumin level, alteration of bone mineral density, histopathological, and radiographical analysis were assessed to evaluate the anti-arthritic effect. Lipid peroxidation and antioxidant enzyme activities in joint tissue homogenate were performed along with the expression of different pro-inflammatory cartilage cytokines like TNF-α and IL-6. Dexamethasone and epigallocatechin combination potentiated both the antiarthritic (decrease of hind paw volume) and the antioxidant effect (lipid peroxidation, superoxide dismutase, glutathione reductase and catalase). In combination with dexamethasone, epigallocatechin markedly potentiated the beneficial effect of dexamethasone which resulted in more significant increment of serum albumin and bone mineral density. Improvement of anti-arthritic effect of combination therapy was supported by histopathological, radiographical alterations, and attenuation of over-expression of cartilage cytokines. Epigallocatechin act as potent antioxidant and combined administration of dexamethasone with epigallocatechin increased the anti-arthritic efficacy of basal dexamethasone therapy and suppressed the development phase of arthritic progression in rats. 相似文献
60.