Synthesis and Pharmacological Evaluation of Carvacrol Propionate

This study aimed at synthesizing the carvacrol propionate (CP) and evaluating its pharmacological profile. CP was obtained from carvacrol and propionyl chloride through an esterification reaction. Male Swiss mice were treated with CP (25, 50, or 100 mg/kg). We evaluated the analgesic effect, mechanical hyperalgesia, and anti-inflammatory effect. Pre-treatment with CP inhibited (p?p?p?TNF-α (p?p?p?p?相似文献   

Using Mitochondrial Genome Sequences to Track the Origin of Imported Plasmodium vivax Infections Diagnosed in the United States

Although the geographic origin of malaria cases imported into the United States can often be inferred from travel histories, these histories may be lacking or incomplete. We hypothesized that mitochondrial haplotypes could provide region-specific molecular barcodes for tracing the origin of imported Plasmodium vivax infections. An analysis of 348 mitochondrial genomes from worldwide parasites and new sequences from 69 imported malaria cases diagnosed across the United States allowed for a geographic assignment of most infections originating from the Americas, southeast Asia, east Asia, and Melanesia. However, mitochondrial lineages from Africa, south Asia, central Asia, and the Middle East, which altogether contribute the vast majority of imported malaria cases in the United States, were closely related to each other and could not be reliably assigned to their geographic origins. More mitochondrial genomes are required to characterize molecular barcodes of P. vivax from these regions.     

Carcinoma Ex Pleomorphic Adenoma of the Palate Composed of Invasive Micropapillary Salivary Duct Carcinoma and Adenoid Cystic Carcinoma Components: An Unusual Case With Immunohistochemical Approach

Carcinoma ex pleomorphic adenoma (CXPA) is an unusual epithelial malignancy that develops from a primary or recurrent pleomorphic adenoma (PA), the most common tumor of salivary glands, and constitutes about 11.5% of all carcinomas that affect these glands. Intraoral minor salivary glands and seromucous glands of the oropharynx are uncommon locations of CXPA. On histopathological examination, the tumor comprises a wide morphological spectrum with a variable proportion between the benign and malignant components with the latter often predominating and overlapping the PA, which may cause misdiagnosis. Here, we report a case of palatal minor salivary gland CXPA composed of invasive micropapillary salivary duct carcinoma and adenoid cystic carcinoma components with multiple nodal metastases in a 74-year-old woman. Neoplastic cells showed heterogeneous immunohistochemical profile with both luminal and myoepithelial differentiation. The invasive micropapillary salivary duct carcinoma component demonstrated overexpression of the oncoprotein human epidermal growth factor receptor-2. This feature should be considered and evaluated as a possible target for adjuvant therapy in case of metastatic disease.     

Analysis of behavior of the wear coefficient in different layers of acrylic resin teeth

Statement of problemAnalysis of the wear coefficient (k) of the superficial and deep layers of acrylic resin teeth can help predict denture durability, but little has been published on the wear coefficient of denture teeth.PurposeThe purpose of this in vitro study was to determine the k value for the superficial and deep layers of the acrylic resin teeth of 6 different brands by using the fixed-ball microabrasive wear method.Material and methodsSix artificial tooth specimens of 4 commercial brands were tested: Artiplus IPN (Ar), Biotone IPN (Bi), Magister (Ma), Premium (Pr), Trilux (Tr), and SR Vivodent (Vi). Two specimens from each brand were created, one for the superficial layer and the other for the deep layer. The test was performed on fixed-ball microabrasive wear equipment set to operate at a constant normal force of 0.5 N and a rotation speed of 100 rpm. The test time periods were 5.00, 8.33, and 11.66 minutes. The characteristics of the wear craters were measured by using an optical microscope at a magnification of ×50 and Leica Microsystems software. Wear coefficient (k) values were deduced by using the Archard equation for abrasive wear, Q=k·N, and were analyzed by using 1-way analysis of variance, complemented by the Tukey HSD test (α=.05). A different analysis was used for each layer.ResultsThe analysis of variance of the wear coefficient revealed significant differences among the groups regarding the superficial layers (P=.009). The Tukey HSD test showed that the k values for the superficial layers of Artiplus specimens were significantly lower than those of the Vivodent and Magister specimens.ConclusionsOne brand (Ar) presented significantly lower wear coefficient value for the surface layer. No difference in wear coefficient values was found among the tooth brands for the deep layer.     

Comparison of Virtual Nutri Plus® and Dietpro 5i® software systems for the assessment of nutrient intake before and after Roux-en-Y gastric bypass

OBJECTIVES:

The assessment of nutritional intake before and after bariatric surgery assists in identifying eating disorders, nutritional deficiencies and weight loss/maintenance. The 7-day record is the gold standard for such an assessment and is interpreted using specialized software. This study sought to compare the Virtual Nutri Plus® and Dietpro 5i® software systems in assessing nutrient intake in obese patients with type 2 diabetes mellitus who underwent a Roux-en-Y gastric bypass.

METHODS:

Nutritional intake was assessed in 10 obese women with type 2 diabetes mellitus before and 3 months after Roux-en-Y gastric bypass. The 7-day record was used to assess food intake and then, the Virtual Nutri Plus® and Dietpro 5i® software systems were used to calculate calorie, macronutrient and micronutrient intake based on validated food chemical composition databases. Clinicaltrials.gov: {"type":"clinical-trial","attrs":{"text":"NCT01251016","term_id":"NCT01251016"}}NCT01251016.

RESULTS:

During the preoperative period, deficits in the ingestion of total fiber and 15 out of 22 estimated micronutrients were observed when using the Virtual Nutri Plus®, compared to deficiencies in total fiber and 4 micronutrients when using the Dietpro 5i®. During the postoperative period, both the Virtual Nutri Plus® and Dietpro 5i® systems detected deficits in the ingestion of total fiber, carbohydrates and 19 micronutrients, but only the Virtual Nutri Plus® detected deficits in complex B vitamins (except B12) and minerals.

CONCLUSION:

Virtual Nutri Plus® was more sensitive than Dietpro 5i® for the identification of deficits in nutrient intake in obese, type 2 diabetes mellitus patients undergoing Roux-en-Y gastric bypass.