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91.
Jorge G. Muñiz Ortiz Kathleen A. Wallace Fabian Leinisch Maria B. Kadiiska Ronald P. Mason Andrew D. Kligerman 《Environmental and molecular mutagenesis》2013,54(5):317-326
Although it is widely known that arsenic‐contaminated drinking water causes many diseases, arsenic's exact mode of action (MOA) is not fully understood. Induction of oxidative stress has been proposed as an important key event in the toxic MOA of arsenic. The authors' studies are centered on identifying a reactive species involved in the genotoxicity of arsenic using a catalase (CAT) knockout mouse model that is impaired in its ability to breakdown hydrogen peroxide (H2O2). The authors assessed the induction of DNA damage using the Comet assay following exposure of mouse Cat+/+ and Cat?/? primary splenic lymphocytes to monomethylarsonous acid (MMAIII) to identify the potential role of H2O2 in mediating cellular effects of this metalloid. The results showed that the Cat?/? lymphocytes are more susceptible to MMAIII than the Cat+/+ lymphocytes by a small (1.5‐fold) but statistically significant difference. CAT activity assays demonstrated that liver tissue has approximately three times more CAT activity than lymphocytes. Therefore, Comet assays were performed on primary Cat+/+, Cat+/?, and Cat?/? hepatocytes to determine if the Cat?/? cells were more susceptible to MMAIII than lymphocytes. The results showed that the Cat?/? hepatocytes exhibit higher levels of DNA strand breakage than the Cat+/+ (approximately fivefold) and Cat+/? (approximately twofold) hepatocytes exposed to MMAIII. Electron spin resonance using 5,5‐dimethyl‐1‐pyrroline‐N‐oxide as the spin‐trap agent detected the generation of ·OH via MMAIII when H2O2 was present. These experiments suggest that CAT is involved in protecting cells against the genotoxic effects of the ·OH generated by MMAIII. Environ. Mol. Mutagen. 54:317–326, 2013. © 2013 Wiley Periodicals, Inc. 相似文献
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R. Fernández‐de‐Misa B. Hernández‐Machín O. Servitje F. Valentí‐Medina L. Maroñas‐Jiménez P. L. Ortiz‐Romero J. Sánchez Schmidt R. M. Pujol F. Gallardo I. Pau‐Charles M. P. García Muret S. Pérez Gala C. Román J. Cañueto L. Blanch Rius R. Izu A. Ortiz‐Brugués R. M. Martí M. Blanes M. Morillo P. Sánchez Y. Peñate J. Bastida A. Pérez Gil I. Lopez‐Lerma C. Muniesa T. Estrach 《Clinical and experimental dermatology》2018,43(2):137-143
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Belén Rubio‐González M.D. Beatriz García‐Bracamonte M.D. Pablo L. Ortiz‐Romero M.D. Concepción Postigo‐Llorente M.D. Francisco Vanaclocha‐Sebastián M.D. 《Pediatric dermatology》2014,31(3):e87-e89
We report the first case of multisystemic Langerhans cell histiocytes mimicking diffuse neonatal hemangiomatosis clinically. This has been described in patients with congenital self‐healing reticulohistiocytosis but not in patients with acute, disseminated, and multisystemic disease. In our experience, dermoscopic findings did not help to diagnose the condition. 相似文献
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Immunization of pregnant women against influenza is a promising strategy to protect the mother, fetus, and young infant from influenza-related diseases. The burden of influenza during pregnancy, the vaccine immunogenicity during this period, and the robust influenza vaccine safety database underpin recommendations that all pregnant women receive the vaccine to decrease complications of influenza disease during their pregnancies. Recent data also support maternal immunization for the additional purpose of preventing disease in the infant during the first six months of life. 相似文献
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