全文获取类型
收费全文 | 815篇 |
免费 | 63篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 22篇 |
妇产科学 | 40篇 |
基础医学 | 83篇 |
口腔科学 | 33篇 |
临床医学 | 107篇 |
内科学 | 128篇 |
皮肤病学 | 27篇 |
神经病学 | 82篇 |
特种医学 | 26篇 |
外科学 | 55篇 |
综合类 | 5篇 |
预防医学 | 104篇 |
眼科学 | 4篇 |
药学 | 98篇 |
中国医学 | 19篇 |
肿瘤学 | 47篇 |
出版年
2023年 | 4篇 |
2022年 | 7篇 |
2021年 | 11篇 |
2020年 | 13篇 |
2019年 | 20篇 |
2018年 | 21篇 |
2017年 | 13篇 |
2016年 | 18篇 |
2015年 | 15篇 |
2014年 | 22篇 |
2013年 | 25篇 |
2012年 | 47篇 |
2011年 | 49篇 |
2010年 | 25篇 |
2009年 | 32篇 |
2008年 | 58篇 |
2007年 | 36篇 |
2006年 | 46篇 |
2005年 | 32篇 |
2004年 | 22篇 |
2003年 | 28篇 |
2002年 | 25篇 |
2001年 | 18篇 |
2000年 | 19篇 |
1999年 | 18篇 |
1998年 | 15篇 |
1997年 | 11篇 |
1996年 | 8篇 |
1995年 | 9篇 |
1994年 | 5篇 |
1993年 | 8篇 |
1992年 | 21篇 |
1991年 | 10篇 |
1990年 | 13篇 |
1989年 | 6篇 |
1988年 | 15篇 |
1987年 | 10篇 |
1986年 | 12篇 |
1985年 | 17篇 |
1984年 | 24篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 9篇 |
1980年 | 4篇 |
1979年 | 10篇 |
1978年 | 8篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1969年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有884条查询结果,搜索用时 396 毫秒
811.
In contrast to previous assumptions, albumin is not the only protein in normal human serum responsible for binding quinidine. Human serum proteins were fractionated by gel filtration and floatation. Quinidine binding was determined by equilibrium dialysis. The binding to low (LDL) and high (HDL) density lipoproteins exhibited two binding sites on each protein, and the dissociation constants K and number of binding sites n were calculated. LDL: K1 = 2 × 10?5, n1 = 1 and K2 = 5·2 × 10?4, n2 = 97. HDL: K1 = 1·9 × 10?5, n1 = 0·1 and K2 = 1·1 × 10?3, n2 = 14·7. 相似文献
812.
Rat livers were perfused in situ with [125I]-transferrin, FITC-dextran and [32P]-inorganic pyrophosphate (PP). In a parallel set of experiments rat liver homogenates was incubated with [125I]-transferrin and [32P]-PPi. In both sets of experiments cellular organelles were prepared by density gradient centrifugation in metrizamide. In the perfusion experiments [125I]-transferrin and FITC-dextran accumulated in fractions rich in plasma membrane enzymes, whereas in the homogenate experiments [125I]-transferrin remained in soluble fractions. [32P]-PPi remained in soluble fractions in both sets of experiments, i.e. PPi did not co-localize with transferrin taken up by intact cells. In another set of experiments fractions rich in endosomes were tested for their ability to synthesize PPi from ATP. No PPi was found. The results argue against a role for PPi in transferrin-iron release within endosomes. 相似文献
813.
814.
815.
816.
817.
Asbjrn M. Nilsen Erling A. Mylius Barbro M. Gullvg 《American journal of industrial medicine》1987,12(1):101-112
According to a method (the AM-test) previously developed by us, the counting of alveolar macrophages (AM) from expectorates provides an estimation of the potential pulmonary insult from occupational air pollution +/- smoking. In this article we demonstrate a relationship between the number of AM and self-registered pulmonary symptoms and complaints. Employees from different workplaces in a primary aluminum reduction plant gave expectorate samples for the AM-test. A gradient in the number of AM was observed, with increasing AM numbers from the controls to the administration employees to the potroom workers, who had the highest numbers. Pulmonary symptoms and complaints were recorded by means of a questionnaire. A clear covariation between AM numbers and respiratory symptoms and complaints was observed and was most pronounced at the highest pollution levels (in the potrooms). We therefore suggest that the AM-test may serve as an effect indicator as well as a dose indicator. 相似文献
818.
Vatten LJ Nilsen TI Tretli S Trichopoulos D Romundstad PR 《International journal of cancer. Journal international du cancer》2005,114(3):461-464
It has been hypothesized that birth size is positively associated with breast cancer risk in adulthood. We studied birth length, birth weight and head circumference at birth and subsequent risk for breast cancer in a cohort of 16,016 women in Norway. Birth length was positively associated with risk (p trend = 002), and women who were 53 cm or longer had a relative risk of 1.8 (CI = 1.2-2.6) compared with women who were shorter than 50 cm, after adjustment for birth year, length of gestation, birth order, maternal age, maternal marital status and socioeconomic status at childbearing. Mutual adjustment for birth weight did not influence the results, and further adjustment for maternal height and adult factors (age at first birth and parity) in a subset of the cohort did not change the results. For birth weight, women in the highest category (>/= 3,840 g) had an adjusted relative risk (RR) of 1.5 (CI = 1.0-2.2) compared to women in the lowest (< 3,040 g), but mutual adjustment for birth length attenuated this association (RR = 1.1; CI = 0.7-1.8). Head circumference at birth showed a similar association as birth weight, with attenuation after mutual adjustment for birth length. The positive association with birth length was stronger among women whose mothers were relatively tall (median or taller, p trend = 0.001) compared to women whose mothers were relatively short (below median, p trend = 0.67) at childbearing. The results provide evidence that intrauterine factors influence future breast cancer risk. The positive association related to birth length suggests that factors that stimulate intrauterine longitudinal growth are particularly important. 相似文献
819.
Folate supplementation and twin pregnancies 总被引:2,自引:0,他引:2
Vollset SE Gjessing HK Tandberg A Rønning T Irgens LM Baste V Nilsen RM Daltveit AK 《Epidemiology (Cambridge, Mass.)》2005,16(2):201-205
BACKGROUND: Women in many countries are advised to increase their folate intake to lower the risk of neural tube defects. For this purpose several countries add folate to the flour. Therefore, it is important to monitor possible adverse effects of this B vitamin. We have assessed the effect of folate on twin pregnancies. METHODS: We conducted a retrospective, population-register based study of 176,042 women who gave birth from December 1998 through the end of 2001. Use of folate and multivitamin supplements was recorded on the mandatory birth notification form of the Medical Birth Registry of Norway. Pregnancies after in vitro fertilization (IVF) were reported separately. RESULTS: With adjustment for maternal age and parity, we observed an increased risk of twin pregnancies associated with preconceptional use of folate (odds ratio = 1.59; 95% confidence interval = 1.41-1.78). This association was largely explained by confounding with IVF pregnancies, which were strongly associated both with twin pregnancies and folate use. After exclusion of known IVF pregnancies, and accounting for underreporting of both IVF pregnancies and folate use, the risk was no longer elevated (1.02; 0.85-1.24). Weak associations with twin pregnancies were observed for use of multivitamins and folate during pregnancy, but could be due to increased use of vitamins after a recognized twin pregnancy. CONCLUSIONS: The association between preconceptional folate use and twin pregnancies was strongly confounded by IVF. After accounting for IVF pregnancies and underreporting, we found no evidence for an association between preconceptional folate supplements and twinning. 相似文献
820.