全文获取类型
收费全文 | 149555篇 |
免费 | 31175篇 |
国内免费 | 2391篇 |
专业分类
耳鼻咽喉 | 5157篇 |
儿科学 | 5339篇 |
妇产科学 | 2377篇 |
基础医学 | 2954篇 |
口腔科学 | 1477篇 |
临床医学 | 26564篇 |
内科学 | 46971篇 |
皮肤病学 | 7428篇 |
神经病学 | 14664篇 |
特种医学 | 6330篇 |
外科学 | 40752篇 |
综合类 | 242篇 |
现状与发展 | 72篇 |
预防医学 | 6952篇 |
眼科学 | 3326篇 |
药学 | 883篇 |
中国医学 | 7篇 |
肿瘤学 | 11626篇 |
出版年
2024年 | 686篇 |
2023年 | 4793篇 |
2022年 | 1227篇 |
2021年 | 3125篇 |
2020年 | 6024篇 |
2019年 | 2154篇 |
2018年 | 7376篇 |
2017年 | 7327篇 |
2016年 | 8385篇 |
2015年 | 8380篇 |
2014年 | 15440篇 |
2013年 | 15554篇 |
2012年 | 5349篇 |
2011年 | 5356篇 |
2010年 | 10286篇 |
2009年 | 14172篇 |
2008年 | 5673篇 |
2007年 | 3901篇 |
2006年 | 6369篇 |
2005年 | 3657篇 |
2004年 | 2929篇 |
2003年 | 1910篇 |
2002年 | 1998篇 |
2001年 | 3774篇 |
2000年 | 2987篇 |
1999年 | 3188篇 |
1998年 | 3626篇 |
1997年 | 3450篇 |
1996年 | 3352篇 |
1995年 | 3203篇 |
1994年 | 1935篇 |
1993年 | 1558篇 |
1992年 | 1367篇 |
1991年 | 1399篇 |
1990年 | 1050篇 |
1989年 | 1170篇 |
1988年 | 1009篇 |
1987年 | 846篇 |
1986年 | 880篇 |
1985年 | 710篇 |
1984年 | 543篇 |
1983年 | 517篇 |
1982年 | 511篇 |
1981年 | 398篇 |
1980年 | 359篇 |
1979年 | 306篇 |
1978年 | 329篇 |
1977年 | 396篇 |
1975年 | 277篇 |
1972年 | 303篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
921.
Submassive hepatic necrosis associated with the use of progabide: A GABA receptor agonist 总被引:2,自引:0,他引:2
Santiago J. Munoz MD Ruggero Fariello MD Willis C. Maddrey MD 《Digestive diseases and sciences》1988,33(3):375-380
Progabide, a recently introduced gamma-aminobutyric acid mimetic, is currently undergoing clinical evaluation for a variety of convulsive disorders. We describe a patient in whom severe hepatic failure developed after four weeks of Progabide therapy. The patient's course was marked by encephalopathy, jaundice, hypoglycemia, markedly elevated serum aminotransferase levels, and prolongation of the prothrombin time. Liver biopsy showed extensive hepatocellular necrosis. The patient recovered slowly after discontinuation of the drug. The finding of eosinophilia and increased serum IgE suggests an immunologically mediated mechanism for the Progabide-induced hepatic injury. Alternatively, the lipophilic moiety of Progabide may interact with hepatocyte cell membrane lipids leading to toxic injury. We conclude that Progabide may occasionally cause severe hepatic injury. 相似文献
922.
Jeffrey R. Rubin MD Enrique Labadie MD Gary Anderson BS James Persky MD Jerry Goldstone MD 《Annals of vascular surgery》1988,2(2):127-132
This study evaluates the effect of blood volume and hematocrit changes on brain tissue during temporary global ischemia. Normal saline was administered intravenously to 55 gerbils to achieve hypo-, normo-, and hypervolemic hemodilution and uniform 30% hematocrit reduction. Each group had unilateral carotid artery ligation and temporary (20 minute) contralateral carotid occlusion. After ten days or death, brains were harvested, preserved in formalin, sectioned in a manner which provided adequate samples of both cortex and hippocampus, and stained with H&E and luxol fast blue. They were then examined and staged microscopically for white and gray matter infarction, edema, and neuronal injury and loss. Histologic studies were performed in a randomized and blinded manner and were classified by one of four categories: normal, minimal, moderate, and severe changes. Three of ten (30%) controls survived ten days but had severe neuronal loss, minimal cerebral edema and a minimal to moderate number of white matter strokes. Survival was best in animals treated with hypovolemic hemodilution (43%). Other rates were: normovolemic (33%), controls (30%), and hypervolemic (8.3%). The degree of brain tissue damage was markedly less in the normovolemic group. In this model, normovolemic hemodilution followed by hypovolemic hemodilution offered the best overall cerebral protection during global ischemia. 相似文献
923.
924.
KEVIN R. BISHOP MSN ARNP MOLLY DOUGHERTY Ph D ARNP RUTH MOONEY Ph D ARNP PHYLLIS GIMOTTY Ph D BRADFORD WILLIAMS MD 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1992,21(5):401-406
OBJECTIVE: To examine factors that affect pelvic muscle response to 12 weeks of pelvic muscle exercise. DESIGN: Repeated measures design in which intravaginal pressures during pelvic muscle contractions were recorded at baseline and after four exercise levels. SETTING: College of Nursing research site in Gainesville, Florida. PARTICIPANTS: Eighty-five parous, community-dwelling women, aged 35-78 years and without incontinence as a primary concern. INTERVENTIONS: A 12-week graded program of regular (three times per week, every other day) pelvic muscle exercise at home. MAIN OUTCOME MEASURES: The hypotheses were that younger age, lower parity, higher baseline intravaginal pressures, and adherence to the pelvic muscle exercise program each would result in significant improvement in maximum intravaginal pressures. RESULTS: The only factor showing significance in predicting a successful outcome was age (t = -2.29, df = 41, one-tail probability = .0136). CONCLUSIONS: Regular, graded exercise over several weeks is needed to build pelvic muscles, and some women who exercise do not improve. Although the reasons for not improving are unclear, age is a significant factor. 相似文献
925.
C Lynn Van Antwerpen MD Sidney M Gospe Jr MD PhD Nancy A Wade MD 《Pediatric neurology》1988,4(6):379-380
A 12-year-old girl developed a reversible myeloradiculopathy 1 week after a wasp sting. Delayed neurologic hypersensitivity reactions to Hymenopteran stings occur primarily in adults. Reactions involving both the peripheral and central nervous systems are extremely rare and have never been reported in a child. The mechanisms underlying this uncommon reaction may be related to age-dependent differences in immunologic responses. 相似文献
926.
927.
M. Ninkovi MD D. uur B. Starovi S. Markovi 《The Journal of hand surgery, European volume》1992,17(6):657-659
AV fistulae are extremely rare complications after hand replantation. In the case presented, the formation of an AV fistula did not occur immediately after the replantation, but after the insertion of the free lateral arm flap to the extensor surface of the replanted hand. This paper discusses the mechanisms responsible for the formation of AV fistulae. 相似文献
928.
929.
930.
Tissue expansion is a well-established technique for the management of soft tissue deficiencies. In congenital hand surgery the construction of an adequate first web is paramount. We used tissue expansion in four hands in three patients with complete complex syndactyly of the first web space. Two of these patients had Apert's syndrome and the other an isolated mitten hand anomaly. The expander is preferably placed early in life so that first web construction is completed in the first year. Tissue expander ports are left exposed. There have been no infections, flap or expander loss in our series. 相似文献