全文获取类型
收费全文 | 18518篇 |
免费 | 1185篇 |
国内免费 | 136篇 |
专业分类
耳鼻咽喉 | 157篇 |
儿科学 | 415篇 |
妇产科学 | 353篇 |
基础医学 | 2146篇 |
口腔科学 | 730篇 |
临床医学 | 1770篇 |
内科学 | 3983篇 |
皮肤病学 | 391篇 |
神经病学 | 1156篇 |
特种医学 | 423篇 |
外国民族医学 | 5篇 |
外科学 | 2432篇 |
综合类 | 481篇 |
一般理论 | 14篇 |
预防医学 | 1543篇 |
眼科学 | 732篇 |
药学 | 1794篇 |
中国医学 | 230篇 |
肿瘤学 | 1084篇 |
出版年
2024年 | 20篇 |
2023年 | 226篇 |
2022年 | 555篇 |
2021年 | 1077篇 |
2020年 | 711篇 |
2019年 | 862篇 |
2018年 | 1026篇 |
2017年 | 719篇 |
2016年 | 779篇 |
2015年 | 789篇 |
2014年 | 1053篇 |
2013年 | 1218篇 |
2012年 | 1651篇 |
2011年 | 1699篇 |
2010年 | 999篇 |
2009年 | 762篇 |
2008年 | 1108篇 |
2007年 | 984篇 |
2006年 | 828篇 |
2005年 | 704篇 |
2004年 | 554篇 |
2003年 | 454篇 |
2002年 | 389篇 |
2001年 | 48篇 |
2000年 | 58篇 |
1999年 | 58篇 |
1998年 | 50篇 |
1997年 | 44篇 |
1996年 | 43篇 |
1995年 | 35篇 |
1994年 | 18篇 |
1993年 | 33篇 |
1992年 | 24篇 |
1991年 | 17篇 |
1990年 | 19篇 |
1989年 | 20篇 |
1988年 | 17篇 |
1987年 | 10篇 |
1986年 | 13篇 |
1985年 | 12篇 |
1984年 | 19篇 |
1983年 | 17篇 |
1982年 | 16篇 |
1981年 | 11篇 |
1980年 | 12篇 |
1979年 | 13篇 |
1978年 | 10篇 |
1976年 | 10篇 |
1974年 | 8篇 |
1973年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 328 毫秒
951.
952.
953.
Baseline Sarcopenia is Associated with Lack of Response to Therapy,Liver Decompensation and High Mortality in Hepatocellular Carcinoma Patients
下载免费PDF全文
![点击此处可从《Asian Pacific journal of cancer prevention》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Hanaa BadranMaha Mohammad ElsabaawyAmr RagabRasha Abdelhafiz AlyAyman AlsebaeyAliaa Sabry 《Asian Pacific journal of cancer prevention》2020,21(11):3285-3290
Objective: hepatocellular carcinoma (HCC) is a dreadful complication of liver cirrhosis. Aim was to study the effect of sarcopenia on the survival in patients with HCC. Methods: we included 262 patients and were followed up for 12 months. Sarcopenia was calculated by skeletal muscle index (SMI). Sarcopenia was defined by SMI ≤39 cm2/m2 for women and ≤50 cm2/m2 for men. Results: patients with sarcopenia (n= 113, 43.1%) were older, mainly males, Child-Pugh class B and smokers. Patients with sarcopenia had lower survival than those without (10.09 vs. 11.72 months). Survival was also lower in Barcelona clinic liver cancer stage C than B and A (9.02 vs. 11.21 vs. 11.89 months). Age and sarcopenia were hazardous of mortality (p <0.05). There was statistically significant difference of serial SMI in patients without baseline sarcopenia unlike patients with baseline sarcopenia. On follow up patients with sarcopenia had higher incidence of ascites (45% vs. 20.4%), spontaneous bacterial peritonitis (21.7% vs. 11.6%), hepatic encephalopathy (28% vs. 11.5%) and bleeding (22.9% vs. 12.7%). Totally patients with sarcopenia had higher incidence of progressive HCC (39% vs. 25.5%). Conclusion: Sarcopenia is associated with lack of response to therapy, liver decompensation and higher mortality in hepatocellular carcinoma patients. 相似文献
954.
Reza Pakzad Pooneh Malekifar Zainab Shateri Milad Zandi Sara Akhavan Rezayat Maral Soleymani Mohammad Reza Karimi Seyed Esmaeil Ahmadi Ramin Shahbahrami Iraj Pakzad Fatemeh Abdi Abbas Farahani Saber Soltani Mina Mobini Kesheh Parastoo Hosseini 《Journal of clinical laboratory analysis》2022,36(1)
BackgroundTo provide information about pathogens’ coinfection prevalence with SARS‐CoV‐2 could be a real help to save patients’ lives. This study aims to evaluate the pathogens’ coinfection prevalence among COVID‐19 patients.MethodIn order to find all of the relevant articles, we used systematic search approach. Research‐based databases including PubMed, Web of Science, Embase, and Scopus, without language restrictions, were searched to identify the relevant bacterial, fungal, and viral coinfections among COVID‐19 cases from December 1, 2019, to August 23, 2021. In order to dig deeper, other scientific repositories such as Medrxiv were probed.ResultsA total of 13,023 studies were found through systematic search. After thorough analysis, only 64 studies with 61,547 patients were included in the study. The most common causative agents of coinfection among COVID‐19 patients were bacteria (pooled prevalence: 20.97%; 95% CI: 15.95–26.46; I 2: 99.9%) and less frequent were virus coinfections (pooled prevalence: 12.58%; 95% CI: 7.31–18.96; I 2: 98.7%). The pooled prevalence of fungal coinfections was also 12.60% (95% CI: 7.84–17.36; I 2: 98.3%). Meta‐regression analysis showed that the age sample size and WHO geographic region did not influenced heterogeneity.ConclusionWe identified a high prevalence of pathogenic microorganism coinfection among COVID‐19 patients. Because of this rate of coinfection empirical use of antibacterial, antifungal, and antiviral treatment are advisable specifically at the early stage of COVID‐19 infection. We also suggest running simultaneously diagnostic tests to identify other microbiological agents’ coinfection with SARS‐CoV‐2. 相似文献
955.
Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune- epidemiology
Chimaobi M.Anugwom Manon Allaire Sheikh Mohammad Fazle Akbar Amir Sultan Steven Bollipo Angelo Z.Mattos Jose D.Debes 《肝癌研究(英文版)》2021,7(3):73-87
Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dr... 相似文献
956.
Mostafa M. El-Naggar Ahmed A. Elayat M. Salleh M. Ardawi Mohammad Tahir 《Anatomical record (Hoboken, N.J. : 2007)》1993,237(4):489-497
Although there is a recent increase in the use of the isolated pancreatic islets of the rat in the transplantation and functional studies, there has been no detailed quantitative assessment on the size and cellular constituents of islets after the isolation procedure. The present work was undertaken to study the size classes of the isolated islets and the morphometry of their cellular populations. Islets of the rat pancreas were isolated by using the intraductal collagenase digestion technique, the most commonly used procedure for the isolation of pancreatic islets. Different endocrine cells of the isolated islets were stained by immunoperoxidase staining techniques. The distribution of the cellular constituents of the isolated islets was similar to that of the intact islets of the normal pancreas; A, D, and PP cells were peripherally arranged around the centrally located B cells. However, morphometric quantitative study showed that the percent volume and percent number of A, D, and PP cells of the isolated islets were lower than those of the corresponding intact ones. Further, the mean true diameter of the isolated islets was lower than that of the intact ones. These data indicate loss of islet cells during the process of isolation. Most of the lost cells were from the periphery of islets. This may provide an explanation for the incomplete metabolic control and recurrence of hyperglycemia encountered after isolated islet transplantation in the treatment of diabetes mellitus. It seems that further refinements of the isolation techniques are necessary to obtain islet tissue with total cellular integrity, before a complete success in transplantation could be achieved. © 1993 Wiley-Liss, Inc. 相似文献
957.
Mohammad Ashraful Amin Md Taufiqul Islam Ishtiakul Islam Khan Zahid Hasan Khan Firdausi Qadri Ashraful Islam Khan 《Clinical Case Reports》2022,10(1)
Bangladesh recently faced large outbreaks of both COVID‐19 and dengue. We present a case of COVID‐19 and dengue coinfection in a patient who presented with hemoptysis. Our results demonstrate that COVID‐19 and dengue fever are both public health issues in Bangladesh and other dengue‐endemic nations and that they can coexist. 相似文献
958.
Md Minarul Islam Rashedul Alam Hea-Jong Chung Nazim Uddin Emon Mohammad Fazlul Kabir Sajib Rudra Safaet Alam Ahsan Ullah Seong-Tshool Hong Mohammed Aktar Sayeed 《Nutrients》2022,14(2)
Bauhinia scandens L. (Family: Fabaceae) is commonly used to treat cholera, diarrhea, asthma, and diabetes disorder in integrative medicine. This study aimed to screen the presence of phytochemicals (preliminary and UPLC-QTOF–M.S. analysis) and to examine the pharmacological activities of Bauhinia scandens L. stems (MEBS) stem extracts. Besides, in silico study was also implemented to elucidate the binding affinity and drug capability of the selected phytochemicals. In vivo anti diarrheal activity was investigated in mice models. In vitro, antibacterial and antifungal properties of MEBS against several pathogenic strains were evaluated using the disc diffusion method. In addition, in silico study has been employed using Discovery studio 2020, UCFS Chimera, PyRx autodock vina, and online tools. In the anti-diarrheal investigation, MEBS showed a significant dose-dependent inhibition rate in all three methods. The antibacterial and antifungal screening showed a remarkable zone of inhibition, of the diameter 14–26 mm and 12–28 mm, by MEBS. The present study revealed that MEBS has remarkable anti-diarrheal potential and is highly effective in wide-spectrum bacterial and fungal strains. Moreover, the in silico study validated the results of biological screenings. To conclude, MEBS is presumed to be a good source in treating diarrhea, bacterial and fungal infections. 相似文献
959.
960.
Adam Mohammad Alan G Dawson Amrita Bajaj Sridhar Rathinam 《Interactive Cardiovascular and Thoracic Surgery》2022,34(4):697
Pure red cell aplasia caused by true thymic hyperplasia is extremely rare. We report the case of a 25-year-old female diagnosed with pure red cell aplasia. Following a thymectomy confirming true thymic hyperplasia and corticosteroid therapy, complete response was achieved. Patients diagnosed with pure red cell aplasia should be investigated with a computerized tomographic scan to assess for thymic pathology and if present, this should be resected. Follow-up is essential to monitor for recurrence. 相似文献