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991.
Andreone N Tansella M Cerini R Rambaldelli G Versace A Marrella G Perlini C Dusi N Pelizza L Balestrieri M Barbui C Nosè M Gasparini A Brambilla P 《European archives of psychiatry and clinical neuroscience》2007,257(1):3-11
Several magnetic resonance imaging (MRI) studies have shown cerebral atrophy in established schizophrenia, although not in all reports. Discrepancies may mostly be due to population and post-processing differences.
Recently, disruption of cortical white matter integrity has also been reported in chronic patients with schizophrenia. In
this study we explored tridimensional (3D) cerebral volumes and white matter microstructure in schizophrenia with structural and diffusion magnetic resonance. Twenty-five patients with established schizophrenia and 25 1:1 matched normal controls underwent a session of MRI using a Siemens 1.5T-scanner. 3D brain volume
reconstruction was performed with the semi-automatic software Amira (TGS, San Diego, CA), whereas the apparent diffusion coefficients
(ADCs) of cortical white matter water molecules were obtained with in-house developed softwares written in MatLab (The Mathworks-Inc.,
Natick, MA). Compared to controls, patients with schizophrenia had significantly smaller gray matter intracranium and total brain volumes, increased 4th ventricle volumes, and greater temporal and occipital ADCs. Patients treated with typical antipsychotic medication
(N = 9) had significantly larger right lateral and 4th ventricles compared to those on atypical antipsychotic drugs. Intracranial
volumes significantly inversely correlated with left temporal ADC in patients with schizophrenia. Also, age correlated directly
with right, left, and 3rd ventricle volumes and inversely with gray matter intracranium volumes in individuals with schizophrenia.
This study confirmed the presence of cortical atrophy in patients with schizophrenia, especially in those on typical antipsychotic drugs, and the existence of white matter disruption. It also suggested that physiological aging effects on brain anatomy may be
abnormally pronounced in schizophrenia. 相似文献
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Takayasu's arteritis is a rare, idiopathic, chronic inflammatory disease with cell-mediated inflammation, involving mainly the aorta and its major branches. It leads to stenosis, occlusion or aneurysmal degeneration of large arteries. The clinical presentation is characterised by an acute phase with constitutional symptoms, followed, months or years later, by a chronic phase in which symptoms relate to fibrosis or occlusion of vessels. Angiography is the gold standard for diagnosis and for topographical classification and it correlates with symptoms and prognosis. Here we focus on the pathophysiology, clinical and angiographical classification, diagnostic assessment and therapeutic approach of Takayasu's arteritis. 相似文献
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Tedoldi S Paterson JC Hansmann ML Natkunam Y Rüdiger T Angelisova P Du MQ Roberton H Roncador G Sanchez L Pozzobon M Masir N Barry R Pileri S Mason DY Marafioti T Horejsí V 《Blood》2006,107(1):213-221
Transmembrane adaptor proteins (of which 7 have been identified so far) are involved in receptor signaling in immune cells. They have only a short extracellular region, with most of the molecule comprising a substantial intracytoplasmic region carrying multiple tyrosine residues that can be phosphorylated by Src- or Syk-family kinases. In this paper, we report an immunohistologic study of 6 of these molecules in normal and neoplastic human tissue sections and show that they are restricted to subpopulations of lymphoid cells, being present in either T cells (LAT, LIME, and TRIM), B cells (NTAL), or subsets of both cell types (PAG and SIT). Their expression in neoplastic lymphoid cells broadly reflects that of normal lymphoid tissue, including the positivity of plasma cells and myeloma/plasmacytoma for LIME, NTAL, PAG, and SIT. However, this study also revealed some reactions that may be of diagnostic/prognostic value. For example, lymphocytic lymphoma and mantle-cell lymphoma showed similar profiles but differed clearly from follicle-center lymphoma, whereas PAG tended to be selectively expressed in germinal center-derived subsets of diffuse large B-cell lymphoma. These molecules represent a potentially important addition to the panel of immunophenotypic markers detectable in routine biopsies that can be used in hematopathologic studies. 相似文献
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Patriarca F Skert C Bonifazi F Sperotto A Fili C Stanzani M Zaja F Cerno M Geromin A Bandini G Baccarani M Fanin R 《Haematologica》2006,91(9):1268-1272
We evaluated the incidence, risk factors, and clinical outcome of late-onset non-infectious pulmonary complications (LONIPC) in 599 patients who underwent hematopoietic allogeneic stem cell transplantation (HSCT). The 2-year cumulative incidence of LONIPC was 10% among the 438 patients surviving more than 3 months after HSCT. Transplants from an unrelated donor and occurrence of extensive chronic graft-versus-host disease were the variables significantly associated with the development of LONIPC. The 5-year overall survival was significantly worse among patients with LONIPC than among those without (34% vs 65%, p=0.009). Causes of death were respiratory failure and infections. The relapse rate was similar in the two groups. 相似文献
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Antonio Dello Russo Roberto Biddau Gemma Pelargonio Michela Casella Antonio Frontera Antonella Camporeale Caterina Bisceglia Giovanni B. Forleo Claudio Tondo Paolo Zecchi Fulvio Bellocci 《Journal of interventional cardiac electrophysiology》2009,24(2):147-150
We report the case of a 50 year-old woman referred for extraction of an infected biventricular implantable cardioverter defibrillator
(ICD) who underwent device and leads extraction. Due to adhesions at the level of the subclavian–innominate vein angle, manual
traction with locking stylet was ineffective. A new mechanical sheath provided with a stainless steel bladed tip, the Evolution™
Mechanical Dilator Sheath (Cook Medical), was successfully used to complete lead extraction. As far as we know, this is the
first report on the use of this new tool; its safety should be ascertained by increasing the number of cases but its simple
use and its low cost make the Evolution™ Mechanical Dilator Sheath a new interesting tool that can be added to the instruments
available for lead extraction.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献