肺炎支原体感染伴心肌受累(附46例分析)

近年来国内外陆续有对肺炎支原体 (MP)肺外脏器受累和心脏受累的报道 ,为了进一步研究证实我地区该病的心脏受累情况及发生率。方法 :对 30 7例门诊及住院确诊为MP感染的患儿进行临床、心电图、胸部X线检查 ,并记录有关症状和体征 ,必要时测心肌酶谱 ,对发现有心脏受累者除按MP感染治疗外尚给予心脏支持疗法 ,并定期随访。结果 :有心脏受累者 46例、占 1 4 9% ,平均年龄 9 8±S1 72a。结论 :本文心脏受累者占MP感染的发生率较文献报道 (4 9% )明显为高 ,可能与多数患儿发病年龄较大存在再感染有关。我们认为凡MP感染的患儿应把心电图检查做为常规检查项目。     

安胃降逆饮对大鼠胃功能的影响

目的 观察安胃降逆饮对胃功能的影响,分析其镇吐作用机制。方法 采用大鼠离体胃条法测定胃条张力,小鼠粉红排空试验法测定胃排空量和０．１ｍｏｌ／Ｌ ＮａＯＨ滴定法测定胃酸含量。结果安胃降逆饮对大鼠胃肌物基础张力和乙酰胆碱引起的痉挛性收缩有明显抑制作用（Ｐ〈０．０１）,对小鼠胃排空,大鼠胃液量,胃液酸度及总酸度无明显影响（Ｐ〉０．０５）。结论 安胃降逆饮的镇吐作用至少部分是通过抑制胃肠平滑肌蠕动而发挥作     

琼脂糖微囊化成猪胰岛异种移植实验研究

目的观察实验性糖尿病大鼠腹腔内移植琼脂糖微囊化成猪胰岛治疗效果。方法以琼脂糖作为制备微囊的材料,用相分离方法包被成猪胰岛,将18只糖尿病大鼠随机分为3组对照组、未微囊化胰岛移植组、微囊化胰岛移植组,分别进行腹腔内胰岛移植。结果移植前3组血糖水平无显著差异,移植后7天时,3组血糖分别为(22.67±1.15)mmol／L,(18.58±2.62)mmol／L和(12.38±2.68)mmol/L,微囊化胰岛移植组与前2组相比均有显著差异,且生存期明显长于前2组。结论琼脂糖微囊化成猪胰岛可存活于糖尿病大鼠体内,并且具有生物活性。     

甲苯咪唑微丸质量标准的研究

目的：建立对甲苯咪唑微丸进行定性鉴别和含量测定的方法。方法：采用薄层层析法进行定性鉴别,用紫外分光光度法进行含量测定。结果：含量测定方法平均回收率为１００．６％ , Ｒ Ｓ Ｄ＝ １．７２％ 。结论：所用方法简便可靠,可控制甲苯咪唑微丸的质量。     

中国健康中青年女性全血比粘度参考值与海拔高度的关系

目的：为制定中国健康中青年女性全血比粘度参考值的统一标准提供科学依据。方法：收集了中国各地用毛细管法测定的健康中青年女性全血比粘度参考值,并对其与海拔高度的关系进行了研究。结果：发现随着海拔高度的逐渐增大,健康中青年女性全血比粘度参考值也在逐渐增大,相关性很显著。用一元回归分析的方法推导出一个回归方程。结论：如果知道了中国某地的海拔高度,就可以用回归方程估算这个地区的健康中青年女性全血比粘度参考值。     

霍乱弧菌O139菌毛微球疫苗制备初探

为寻求Ｏ１３９型霍乱弧菌菌毛疫苗研制的新途径,用高分子聚乳酸－聚乙二醇共聚物（ＤＬ－ＰＬＧ）包裹毒素共调菌毛（ＴＣＰ）抗的,进行免疫学研究,结果表明微轩比游离疫苗诱导的抗体水平高,其中小鼠血清ＩｇＧ以皮下ＭＳ－ＴＣＰ组最高,唾液中的ｓＩｇＡ以口服ＭＳ－ＴＣＰ组最高,口服组主要诱导粘膜免疫,皮下组主要导全身性免疫,ＴＣＰ是霍乱弧菌的共同抗原之一,可作为霍乱疫苗的候选抗原。     

猪背驮式原位肝移植的动物模型

为建立猪背驮式原位肝移植（ＰＢＯＬＴ）模型,共施行ＰＢＯＬＴ１２次。结果表明：１２次ＰＢＯＬＴ术后成活１０头,手术成功率８３３％;平均手术时间７±１ｈ,平均无肝期３４±１２ｍｉｎ,平均失血量１２００±２００ｍｌ。术后各时期病理学检查示移植肝形态结构正常。提示建立猪ＰＢＯＬＴ模型具可行性。缩短无肝期对手术成功有重要意义。     

十二指肠腔内置管引流减压在毕-Ⅱ式胃大部切除术中应用疗效的观察

目的探讨防止毕-Ⅱ式胃大部切除术后十二指肠残端破裂发生的方法;方法对毕-Ⅱ式胃大部切除术中出现十二指肠残端水肿或血运差的病例,采取预防性十二指肠腔内置管引流减压的方法,收集临床资料、观察治疗效果;结果采取十二指肠腔内置管引流减压后,十二指肠残端破裂发生率明显下降;结论十二指肠腔内置管引流减压,可以预防十二指肠残端破裂的发生,并可拓宽溃疡穿孔病例采用胃大部切除术的适应证。     

Design and synthesis of modified quinolones as antitumoral acridones.

The bacterial topoisomerase II (DNA gyrase) and the mammalian topoisomerase II represent the cellular targets for quinolone antibacterials and a wide variety of anticancer drugs, respectively. In view of the mechanistic similarities and sequence homologies exhibited by the two enzymes, tentative efforts to selectively shift from an antibacterial to an antitumoral activity was made by synthesizing a series of modified tricyclic quinolones, in which the essential 3-carboxylic function is surrogated by phenolic OH and the classic C-6 fluorine atom is replaced by a NH2 group. The resulting 7-amino-9-acridone derivatives were assayed for their antibacterial as well as cytotoxic activities. No antibacterial activity was found. On the other hand, many derivatives showed significant cytotoxic activity against both HL-60 and P388 leukemias and a wide panel of human and rodent solid tumor cells, derivatives 25 and 26 displaying the best overall antiproliferative activity. Against the LoVo cell line, derivative 25 exhibited higher cytotoxic effects than etoposide.     

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones

Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype selectivity for the cloned human alpha(1a) receptor. Systematic modifications of 12 led to identification of highly potent and subtype-selective compounds such as (+)-30 and (+)-103, with high binding affinity (K(i) = 0.2 nM) for alpha(1a) receptor and greater than 1500-fold selectivity over alpha(1b) and alpha(1d) adrenoceptors. The compounds were found to be functional antagonists in human, rat, and dog prostate tissues. Compound (+)-103 exhibited excellent selectively to inhibit intraurethral pressure (IUP) as compared to lowering diastolic blood pressure (DBP) in mongrel dogs (K(b)(DBP)/K(b)(IUP) = 40) suggesting uroselectivity for alpha(1a)-selective compounds.