全文获取类型
收费全文 | 1608篇 |
免费 | 136篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 34篇 |
妇产科学 | 64篇 |
基础医学 | 233篇 |
口腔科学 | 40篇 |
临床医学 | 170篇 |
内科学 | 323篇 |
皮肤病学 | 36篇 |
神经病学 | 121篇 |
特种医学 | 40篇 |
外科学 | 256篇 |
综合类 | 36篇 |
预防医学 | 125篇 |
眼科学 | 60篇 |
药学 | 118篇 |
中国医学 | 21篇 |
肿瘤学 | 71篇 |
出版年
2024年 | 5篇 |
2023年 | 43篇 |
2022年 | 67篇 |
2021年 | 83篇 |
2020年 | 64篇 |
2019年 | 82篇 |
2018年 | 107篇 |
2017年 | 75篇 |
2016年 | 75篇 |
2015年 | 72篇 |
2014年 | 89篇 |
2013年 | 107篇 |
2012年 | 149篇 |
2011年 | 155篇 |
2010年 | 94篇 |
2009年 | 62篇 |
2008年 | 76篇 |
2007年 | 78篇 |
2006年 | 70篇 |
2005年 | 46篇 |
2004年 | 37篇 |
2003年 | 22篇 |
2002年 | 15篇 |
2001年 | 11篇 |
2000年 | 4篇 |
1999年 | 16篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有1755条查询结果,搜索用时 140 毫秒
61.
Nima Sepehri Maryam Mohammadi-Khanaposhtani Nafise Asemanipoor Samanesadat Hosseini Mahmood Biglar Bagher Larijani Mohammad Mahdavi Haleh Hamedifar Parham Taslimi Nastaran Sadeghian Ilhami Gulcin 《Archiv der Pharmazie》2020,353(10):2000109
Coumarins and their derivatives are receiving increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel coumarin–1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including α-glycosidase (α-Gly), α-amylase (α-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. The new coumarin–1,2,3-triazole-acetamide hybrids showed Ki values in the range of 483.50–1,243.04 nM against hCA I, 508.55–1,284.36 nM against hCA II, 24.85–132.85 nM against AChE, 27.17–1,104.36 nM against BChE, 590.42–1,104.36 nM against α-Gly, and 55.38–128.63 nM against α-Amy. The novel coumarin–1,2,3-triazole-acetamide hybrids had effective inhibition profiles against all tested metabolic enzymes. Also, due to the enzyme inhibitory effects of the new hybrids, they are potential drug candidates to treat diseases such as epilepsy, glaucoma, type-2 diabetes mellitus (T2DM), Alzheimer's disease (AD), and leukemia. Additionally, these inhibition effects were compared with standard enzyme inhibitors like acetazolamide (for hCA I and II), tacrine (for AChE and BChE), and acarbose (for α-Gly and α-Amy). Also, those coumarin–1,2,3-triazole-acetamide hybrids with the best inhibition score were docked into the active site of the indicated metabolic enzymes. 相似文献
62.
Azadvari Mohaddeseh Mirmosayyeb Omid Hosseini Maryam Vaheb Saeed Razavi Seyede Zahra Emami 《Neurological sciences》2022,43(6):3879-3892
Neurological Sciences - The prevalence of osteoporosis is reported differently. We designed this systematic review and meta-analysis to estimate pooled prevalence of osteoporosis and osteopenia in... 相似文献
63.
In the stromal keratitis caused by herpes simplex virus (HSV), the formation of new vessels is the essential step for the pathogenesis of keratitis. Inhibition of angiogenesis diminishes the formation of corneal lesion induced by HSV. Procedures which suppress angiogenesis are proposed as a valuable therapeutic approach to control HSK. The mechanism by which HSV ocular infection results in corneal angiogenesis is not understood. Recent reports identified anti-vascular endothelial growth factor (VEGF) as a molecule that is highly expressed in the HSV infected eye and clearly involved in angiogenesis. The advent of VEGF treatments marks a major advancement in the treatment of angiogenic eye disease. Off-label use of bevacizumab (Avastin), a recombinant humanized monoclonal antibody directed against VEGF, in some neovascular disorders of the eye has been associated with promising short term results. Based on these evidences herein we hypothesize topical application of bevacizumab could inhibit corneal neovascularization and also scarring in HSK. We propose this drug as a novel adjunct to current anti-inflammatory strategies in HSK. 相似文献
64.
Lewis W Day BJ Kohler JJ Hosseini SH Chan SS Green EC Haase CP Keebaugh ES Long R Ludaway T Russ R Steltzer J Tioleco N Santoianni R Copeland WC 《Laboratory investigation; a journal of technical methods and pathology》2007,87(4):326-335
POLG is the human gene that encodes the catalytic subunit of DNA polymerase gamma (Pol gamma), the replicase for human mitochondrial DNA (mtDNA). A POLG Y955C point mutation causes human chronic progressive external ophthalmoplegia (CPEO), a mitochondrial disease with eye muscle weakness and mtDNA defects. Y955C POLG was targeted transgenically (TG) to the murine heart. Survival was determined in four TG (+/-) lines and wild-type (WT) littermates (-/-). Left ventricle (LV) performance (echocardiography and MRI), heart rate (electrocardiography), mtDNA abundance (real time PCR), oxidation of mtDNA (8-OHdG), histopathology and electron microscopy defined the phenotype. Cardiac targeted Y955C POLG yielded a molecular signature of CPEO in the heart with cardiomyopathy (CM), mitochondrial oxidative stress, and premature death. Increased LV cavity size and LV mass, bradycardia, decreased mtDNA, increased 8-OHdG, and cardiac histopathological and mitochondrial EM defects supported and defined the phenotype. This study underscores the pathogenetic role of human mutant POLG and its gene product in mtDNA depletion, mitochondrial oxidative stress, and CM as it relates to the genetic defect in CPEO. The transgenic model pathophysiologically links human mutant Pol gamma, mtDNA depletion, and mitochondrial oxidative stress to the mtDNA replication apparatus and to CM. 相似文献
65.
66.
Nakisa Mohammadpour Mehdi Tehrani-Doost Mahmoud Djalali Mostafa Hosseini Mohammad Effatpanah 《Nutritional neuroscience》2018,21(3):202-209
Objectives: Previous studies have shown that serum levels of vitamin D were lower in attention deficit hyperactivity disorder (ADHD) children compared to healthy controls. The aim of the study was to determine the effect of vitamin D supplementation as adjunctive therapy to methylphenidate on symptoms of children with ADHD.Methods: Sixty-two children aged 5–12 years with a diagnosis of ADHD based on DSM-IV criteria were randomly assigned into two groups to receive either 2000IU vitamin D or placebo in addition to methylphenidate for 8 weeks. Symptoms severity was assessed by Conner's Parent Rating Scale-Revised[S] (CPRS), ADHD rating scale-IV (ADHD-RS), and Weekly Parent Ratings of Evening and Morning Behavior (WPREMB) at weeks 0, 4, and 8. Serum levels of 25(OH)D were measured at baseline and after 8 weeks. Anthropometric variables, dietary intake, physical activity, sun exposure, and side effects were assessed.Results: Fifty-four participants completed the trial. After 8 weeks of supplementation, serum levels of 25(OH)D significantly increased in the vitamin D group. ADHD symptoms decreased significantly in both groups (P?0.05). Evening symptoms and total score of WPREMB scale were significantly different at weeks 4 and 8 between the two groups (P?=?0.013, 0.016, respectively), but no differences were found in symptoms by CPRS and ADHD-RS scales.Discussion: Vitamin D supplementation as adjunctive therapy to methylphenidate improved ADHD evening symptoms. Future research is needed to clarify vitamin D effects as monotherapy in ADHD and its mechanism.The trial was registered in www.irct.ir is (IRCT201404222394N10). 相似文献
67.
In the neck or face, there are different causes for subcutaneous emphysema such as injury to the sinuses, the hypopharynx, the laryngotracheal complex, the pulmonary parenchyma, the esophagus or the presence of gas-forming organisms. However, factitious subcutaneous emphysema, a rare cause, must be considered in the differential diagnosis. In this clinical report, we discuss a 20-year-old girl who was under follow-up because of recurrent subcutaneous emphysema of the face and periorbital area.After 2 years of work-ups, including a period of close observation in the intensive care unit, self air injection by syringe was found as the cause of recurrent subcutaneous emphysema of the face, and the patient was labeled as having factitious recurrent subcutaneous emphysema. Therefore, when a patient presents with unexplained recurrent subcutaneous emphysema, one should suspect self-infliction and examine for puncture marks. 相似文献
68.
Buskbjerg Cecilie R. Zachariae Robert Agerbæk Mads Gravholt Claus H. Haldbo-Classen Lene Hosseini S. M. Hadi Amidi Ali 《Brain imaging and behavior》2022,16(1):199-210
Brain Imaging and Behavior - A higher incidence of cognitive impairment (CI) has previously been reported among orchiectomized testicular cancer patients (TCPs), but little is known about the... 相似文献
69.