金樱根中1个新的乌苏烷型三萜皂苷

目的 研究蔷薇科植物金樱子Rosa laevigata根的化学成分.方法 采用硅胶、Sephadex LH-20、ODS柱色谱、重结晶及半制备液相分离和纯化,根据理化性质和波谱数据鉴定化合物的结构,并运用MTT法对所分离化合物对人宫颈癌HeLa、人胃腺癌BGC823、人结肠癌HCT-116及人肝癌HepG-2细胞的细胞...     

Bovine Genitourinary Tuberculosis Revisited

Bovine tuberculosis is now rare in the western world. We reporta case of bovine genitourinary tuberculosis causing obstructiverenal failure. This combination does not appear to have beenpreviously reported.     

A new approach to immunologic identification of factor VIII antibodies

Summary We tested for antibodies against factor VIII by using monoclonal antibody-purified factor VIII preparation as a source of antigen. The factor VIII was adsorbed on nitrocellulose membranes and stored in a refrigerator until later use. Plasma or serum was incubated with the factor VIII containing strip and the antibody was detected by another incubation with peroxidase-labelled antihuman immunoglobulin antibodies. The test was efficient in detecting antibodies in haemophilic and normal subjects with acquired inhibitors to factor VIII. It also detected antibodies to the factor VIII protein in a haemophilic subject with no evidence of inhibitor. The technique is simple, readily applicable, and serves as a useful screening tool for detecting factor VIII antibodies. The stability of the antigen-containing strips in a refrigerator is a practical advantage with potential commercial application.     

青蒿琥酯联合用药及作用机制研究进展

青蒿素是一种从菊科蒿属植物黄花蒿（Artemisia annua）中分离出来的倍半萜类天然产物，青蒿琥酯（artesunate）是其衍生物之一，具有经济、速效、低毒、不易产生耐受等特点。目前临床主要用于脑型疟疾及各种重症疟疾的抢救，对疟原虫红内期有强大且快速杀灭的作用，能够迅速控制临床发作及症状。除此之外，青蒿琥酯还具有抗肿瘤、抗病毒、抗肝纤维化、抗炎、抗菌、保护肝细胞、免疫调节等药理作用，抑制细胞增殖、诱导细胞凋亡及下调血症水平。以青蒿素类化合物为基础的联合疗法（ACTs）是多国治疗疟疾的一线方法，主要包括蒿甲醚-本芴醇、青蒿琥酯-阿莫地喹和青蒿甲醚-苯甲酰胺等。近年来国内外学者对青蒿琥酯进行了研究，发现相对于单一疗法而言，青蒿琥酯联合疗法在增强药理作用、缩短用药时长和减少不良反应等方面更具有优越性。该文通过Web of Science核心合集（Web of Science Core Collection）系统检索并通过CiteSpace（6.2.1）软件对其进行整合，综述了近5年来青蒿琥酯联合其他药物在抗疟、抗肿瘤、抗菌和抗病毒等方面的作用机制并对其进行阐述，旨在为进一步合理开发利用青蒿琥酯及新药研发提供一定的理论依据。