全文获取类型
收费全文 | 2247篇 |
免费 | 142篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 70篇 |
儿科学 | 84篇 |
妇产科学 | 39篇 |
基础医学 | 291篇 |
口腔科学 | 49篇 |
临床医学 | 182篇 |
内科学 | 485篇 |
皮肤病学 | 94篇 |
神经病学 | 150篇 |
特种医学 | 200篇 |
外科学 | 250篇 |
综合类 | 27篇 |
一般理论 | 1篇 |
预防医学 | 148篇 |
眼科学 | 70篇 |
药学 | 114篇 |
1篇 | |
中国医学 | 7篇 |
肿瘤学 | 133篇 |
出版年
2023年 | 9篇 |
2022年 | 11篇 |
2021年 | 27篇 |
2020年 | 23篇 |
2019年 | 46篇 |
2018年 | 53篇 |
2017年 | 38篇 |
2016年 | 38篇 |
2015年 | 47篇 |
2014年 | 64篇 |
2013年 | 90篇 |
2012年 | 99篇 |
2011年 | 101篇 |
2010年 | 73篇 |
2009年 | 93篇 |
2008年 | 70篇 |
2007年 | 116篇 |
2006年 | 94篇 |
2005年 | 105篇 |
2004年 | 90篇 |
2003年 | 88篇 |
2002年 | 89篇 |
2001年 | 74篇 |
2000年 | 73篇 |
1999年 | 49篇 |
1998年 | 58篇 |
1997年 | 60篇 |
1996年 | 48篇 |
1995年 | 26篇 |
1994年 | 35篇 |
1993年 | 31篇 |
1992年 | 30篇 |
1991年 | 40篇 |
1990年 | 36篇 |
1989年 | 50篇 |
1988年 | 41篇 |
1987年 | 35篇 |
1986年 | 40篇 |
1985年 | 34篇 |
1984年 | 31篇 |
1983年 | 31篇 |
1982年 | 17篇 |
1981年 | 15篇 |
1980年 | 14篇 |
1979年 | 9篇 |
1978年 | 12篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1972年 | 5篇 |
1971年 | 5篇 |
排序方式: 共有2395条查询结果,搜索用时 31 毫秒
71.
Itzíar Carrasco Talía Sainz Marie Antoinette Frick Santiago Jimnez de Ory Claudia Fortuny Joaquin Burgos Marta Montero Csar Gaviln María Dolores Falcn Jos Antonio Couceiro Jos Ignacio Bernardino Otilia Bisbal Carmelo Guerrero María Teresa Aldmiz‐Echevarría Juan Berenguer María Luisa Navarro 《Journal of viral hepatitis》2020,27(9):955-958
Direct‐acting antivirals (DAAs) for HCV treatment have improved tolerance and efficacy among adults, but experience in vertical transmission is scarce. In our vertically HIV/HCV co‐infected youth cohort of 58 patients, DAA achieved excellent rates of cure among naïve and pretreated individuals. Treating vertically infected seems important as 29.6% displayed advanced fibrosis at treatment initiation. 相似文献
72.
73.
74.
Jared MP Bullard Arshad N Ahsanuddin Anamarija M Perry L Robbin Lindsay Mahmood Iranpour Antonia Dibernardo Paul G Van Caeseele 《The Canadian Journal of Infectious Diseases & Medical Microbiology》2014,25(6):e87-e89
A child with a complicated medical history that included asplenia acquired an infection with Babesia microti in the summer of 2013 and had not travelled outside of Manitoba. Although the clinical findings were subtle, astute laboratory work helped to reach a preliminary identification of Babesia species, while reference laboratory testing confirmed the diagnosis. Blacklegged ticks (Ixodes scapularis) are known to transmit Borrelia burgdorferi and Anaplasma phagocytophilum in the province; however, the present case represents the first known instance of tick-borne B microti, both in Manitoba and in Canada. The expanding territory of the blacklegged tick increases the relevance of this emerging infection. Clinicians, laboratory medical practitioners and public health officials should be aware of B microti as a potential locally acquired infection in Canada. 相似文献
75.
M Castellanos R Pérez C Carrasco M Hernando-Pérez J Gómez-Herrero PJ de Pablo MG Mateu 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(30):12028-12033
In this study we test the hypothesis that mechanically elastic regions in a virus particle (or large biomolecular complex) must coincide with conformationally dynamic regions, because both properties are intrinsically correlated. Hypothesis-derived predictions were subjected to verification by using 19 variants of the minute virus of mice capsid. The structural modifications in these variants reduced, preserved, or restored the conformational dynamism of regions surrounding capsid pores that are involved in molecular translocation events required for virus infectivity. The mechanical elasticity of the modified capsids was analyzed by atomic force microscopy, and the results corroborated every prediction tested: Any mutation (or chemical cross-linking) that impaired a conformational rearrangement of the pore regions increased their mechanical stiffness. On the contrary, any mutation that preserved the dynamics of the pore regions also preserved their elasticity. Moreover, any pseudo-reversion that restored the dynamics of the pore regions (lost through previous mutation) also restored their elasticity. Finally, no correlation was observed between dynamics of the pore regions and mechanical elasticity of other capsid regions. This study (i) corroborates the hypothesis that local mechanical elasticity and conformational dynamics in a viral particle are intrinsically correlated; (ii) proposes that determination by atomic force microscopy of local mechanical elasticity, combined with mutational analysis, may be used to identify and study conformationally dynamic regions in virus particles and large biomolecular complexes; (iii) supports a connection between mechanical properties and biological function in a virus; (iv) shows that viral capsids can be greatly stiffened by protein engineering for nanotechnological applications. 相似文献
76.
77.
Tai YT Chang BY Kong SY Fulciniti M Yang G Calle Y Hu Y Lin J Zhao JJ Cagnetta A Cea M Sellitto MA Zhong MY Wang Q Acharya C Carrasco DR Buggy JJ Elias L Treon SP Matsui W Richardson P Munshi NC Anderson KC 《Blood》2012,120(9):1877-1887
Bruton tyrosine kinase (Btk) has a well-defined role in B-cell development, whereas its expression in osteoclasts (OCs) further suggests a role in osteoclastogenesis. Here we investigated effects of PCI-32765, an oral and selective Btk inhibitor, on osteoclastogenesis as well as on multiple myeloma (MM) growth within the BM microenvironment. PCI-32765 blocked RANKL/M-CSF-induced phosphorylation of Btk and downstream PLC-γ2 in OCs, resulting in diminished TRAP5b (ED(50) = 17nM) and bone resorption activity. PCI-32765 also inhibited secretion of multiple cytokines and chemokines from OC and BM stromal cell cultures from both normal donors (ED(50) = 0.5nM) and MM patients. It decreased SDF-1-induced migration of MM cells, and down-regulated MIP1-α/CCL3 in MM cells. It also blocked MM cell growth and survival triggered by IL-6 or coculture with BM stromal cells or OCs in vitro. Importantly, PCI-32765 treatment significantly inhibits in vivo MM cell growth (P < .03) and MM cell-induced osteolysis of implanted human bone chips in SCID mice. Moreover, PCI-32765 prevents in vitro colony formation by stem-like cells from MM patients. Together, these results delineate functional sequelae of Btk activation mediating osteolysis and growth of MM cells, supporting evaluation of PCI-32765 as a novel therapeutic in MM. 相似文献
78.
79.