全文获取类型
收费全文 | 1818篇 |
免费 | 401篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 39篇 |
妇产科学 | 179篇 |
基础医学 | 78篇 |
口腔科学 | 41篇 |
临床医学 | 1071篇 |
内科学 | 155篇 |
皮肤病学 | 45篇 |
神经病学 | 157篇 |
特种医学 | 48篇 |
外科学 | 90篇 |
综合类 | 31篇 |
预防医学 | 153篇 |
眼科学 | 3篇 |
药学 | 74篇 |
中国医学 | 3篇 |
肿瘤学 | 55篇 |
出版年
2024年 | 6篇 |
2023年 | 58篇 |
2022年 | 10篇 |
2021年 | 39篇 |
2020年 | 32篇 |
2019年 | 26篇 |
2018年 | 110篇 |
2017年 | 116篇 |
2016年 | 115篇 |
2015年 | 108篇 |
2014年 | 110篇 |
2013年 | 121篇 |
2012年 | 76篇 |
2011年 | 80篇 |
2010年 | 89篇 |
2009年 | 103篇 |
2008年 | 62篇 |
2007年 | 72篇 |
2006年 | 65篇 |
2005年 | 57篇 |
2004年 | 43篇 |
2003年 | 38篇 |
2002年 | 28篇 |
2001年 | 42篇 |
2000年 | 29篇 |
1999年 | 47篇 |
1998年 | 47篇 |
1997年 | 66篇 |
1996年 | 55篇 |
1995年 | 53篇 |
1994年 | 42篇 |
1993年 | 32篇 |
1992年 | 35篇 |
1991年 | 21篇 |
1990年 | 28篇 |
1989年 | 20篇 |
1988年 | 15篇 |
1987年 | 15篇 |
1986年 | 10篇 |
1985年 | 10篇 |
1984年 | 14篇 |
1983年 | 8篇 |
1982年 | 9篇 |
1981年 | 11篇 |
1980年 | 6篇 |
1979年 | 10篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 9篇 |
1975年 | 9篇 |
排序方式: 共有2224条查询结果,搜索用时 15 毫秒
71.
Plasma Aluminum Concentrations in Pediatric Patients Receiving Long‐Term Parenteral Nutrition
下载免费PDF全文
![点击此处可从《JPEN. Journal of parenteral and enteral nutrition》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Glenda Courtney‐Martin PhD RD Christina Kosar MN RN Alison Campbell RD Yaron Avitzur MD Paul W. Wales MD MSc Karen Steinberg MN RN Debra Harrison BScN Kathryn Chambers BASc RD 《JPEN. Journal of parenteral and enteral nutrition》2015,39(5):578-585
Background: Patients receiving long‐term parenteral nutrition (PN) are at increased risk of aluminium (Al) toxicity because of bypass of the gastrointestinal tract during PN infusion. Complications of Al toxicity include metabolic bone disease (MBD), Al‐associated encephalopathy in adults, and impaired neurological development in preterm infants. Unlike the United States, there are no regulations regarding Al content of large‐ and small‐volume parenterals in Canada. We, therefore, aimed to present our data on plasma Al concentration and Al intake from our cohort of pediatric patients receiving long‐term PN. Methods: Plasma Al concentration was retrospectively gathered from the patient charts of all 27 patients with intestinal failure (IF) receiving long‐term PN at The Hospital for Sick Children, Toronto, Canada, and compared with age‐ and sex‐matched controls recruited for comparison. In addition, Al concentration was measured in PN samples collected from 10 randomly selected patients with IF and used to determine their Al intake. Results: The plasma Al concentration of patients with IF receiving long‐term PN was significantly higher than that of control participants (1195 ± 710 vs 142 ± 63 nmol/L; P < .0001). In the subgroup of 10 patients for whom Al intake from their PN solution was determined, mean ± SD Al intake from PN was 15.4 ± 15 µg/kg, 3 times the Food and Drug Administration upper recommended intake level, and Al intake was significantly related to plasma Al concentration (P = .02, r2 = 0.52). Conclusion: Pediatric patients receiving long‐term PN for IF in Canada are at risk for Al toxicity. 相似文献
72.
73.
74.
75.
Background
Patient participation in medication management during hospitalization is thought to reduce medication errors and, following discharge, improve adherence and therapeutic use of medications. There is, however, limited understanding of how patients participate in their medication management while hospitalized.Objective
To explore patient participation in the context of medication management during a hospital admission for a cardiac surgical intervention of patients with cardiovascular disease.Design
Single institution, case study design. The unit of analysis was a cardiothoracic ward of a major metropolitan, tertiary referral hospital in Melbourne, Australia. Multiple methods of data collection were used including pre‐admission and pre‐discharge patient interviews (n = 98), naturalistic observations (n = 48) and focus group interviews (n = 2).Results
All patients had changes made to their pre‐operative cardiovascular medications as a consequence of surgery. More patients were able to list and state the purpose and side‐effects of their cardiovascular medications at pre‐admission than prior to discharge from hospital. There was very little evidence that nurses used opportunities such as medication administration times to engage patients in medication management during hospital admission.Discussion and Conclusions
Failure to engage patients in medication management and provide opportunities for patients to learn about changes to their medications has implications for the quality and safety of care patients receive in hospital and when managing their medications once discharged. To increase the opportunity for patients to participate in medication management, a fundamental shift in the way nurses currently provide care is required. 相似文献76.
C K Fairley S Chen S N Tabrizi M A Quinn J J McNeil S M Garland 《The Journal of infectious diseases》1992,165(6):1103-1106
Assessment of human papillomavirus (HPV) infection usually requires a speculum examination to collect genital specimens. A technique using tampons as a patient-administered method for the collection of specimens was studied by dot blot hybridization (HPV types 6, 11, 16, 18, 31, and 33) and polymerase chain reaction (PCR). Tampons and cervical scrapes were collected from 48 consecutive women attending a dysplasia clinic. Tampons provided a significantly larger pellet volume (P less than .002) and more DNA (P less than .01) than scrapes. There was a close correlation when samples were analyzed for the presence of HPV DNA. Using dot blot hybridization, 8 cervical scrapes (17%) and 9 tampons (19%) were positive for HPV DNA (90% correlation). By PCR, 35 cervical scrapes (73%) and 33 tampons (69%) were positive for HPV DNA (88% correlation). Thus, tampon specimens are an easy method for assessment of genital HPV infection. 相似文献
77.
J. Cornillon M.-C. Vantyghem M.A. Couturier E. de Berranger S. François E. Hermete N. Maillard A. Marcais R. Tabrizi C. Decanter R. Duléry F. Bauters I. Yakoub-Agha 《Pathologie-biologie》2013
In the attempt to harmonize clinical practices between different French transplantation centers, the French Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC) set up the third annual series of workshops which brought together practitioners from all member centers and took place in October 2012 in Lille. Here we report our results and recommendations regarding the management of short and long-term endocrine dysfunction following allogeneic stem cell transplantation. The key aim of this workshop was to give an overview on secondary adrenal insufficiency and osteoporosis post-transplant. 相似文献
78.
Fatma M Ghoneim Hanaa A Khalaf Ayman Z Elsamanoudy Salwa M Abo El-khair Ahmed MN Helaly El-Hassanin M Mahmoud Saad H Elshafey 《International journal of clinical and experimental pathology》2015,8(7):7710-7728
Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive degeneration of the hippocampal and cortical neurons. This study was designed to demonstrate the protective effect of caffeine on gene expression of brain derived neurotrophic factor (BDNF) and its receptor neural receptor protein-tyrosine kinase-β (TrkB) as well as glial fibrillary acidic protein (GFAP) and Ki-67 immunoreactivity in Aluminum chloride (AlCl3) induced animal model of AD. Fifty adult rats included in this study were classified into 5 group (10 rats each); negative and positive control groups (I&II), AD model group (III), group treated with caffeine from the start of AD induction (IV) and group treated with caffeine two weeks before AD induction (V). Hippocampal tissue BDNF and its receptor (TrkB) gene expression by real time RT-PCR in addition to immunohistochemical study of GFAP and Ki67 immunoreactivity were performed for all rats in the study. The results of this study revealed that caffeine has protective effect through improving the histological and immunohistochemical findings induced by AlCl3 as well as BDNF and its receptor gene expression. It could be concluded from the current study, that chronic caffeine consumption in a dose of 1.5 mg/kg body weight daily has a potentially good protective effect against AD. 相似文献
79.
80.