Unusual Placement of a Pacemaker Pocket

Because of infection and extensive radiation injury to the skin of the chest wall, a dual chamber pacemaker was implanted deep to the clavicle. The wound has been stable and comfortable for 1 year and pacemaker programming has been unimpaired.     

Rotavirus Serology and Breast-Feeding in Young Children in Rural Guinea-Bissau

ABSTRACT. One hundred and forty-four children aged 9–20 months living in 14 villages in a rural area of Guinea-Bissau were examined for circulating rotavirus antibodies twice in a 15-month period. An immunofluorescence technique was used. About 3/4 of the children serocon-verted, independent of age on entering the study. The age-specific proportion of seroposi-tivity increased from 4/40 (10%) at 9–11 months to 26/29 (90%) at 33–35 months of age. All the initially seropositive children retained detectable antibodies to rotavirus. The relative risk of seroconversion was 1.4 times (95% confidence interval 1.0–2.0) more common among children living in villages by the mainroad as compared to those living off the road. Contact rate is probably dependent on population density and mobility but not on age. Breast-feeding, decreasing sharply through the age interval covered by the follow-up (9–35 months), had no apparent influence on seroconversion at the ages concerned.     

Experimental Immune Oophoritis As a Model for Studying the Thymus-Ovary Interaction: 1. Morphological Studies

ABSTRACT: The experimental immune oophoritis (EIO) model was used to study the functional relationship between the ovary and organs of the immune system. EIO was developed in Balb/c mice by twofold subcutaneous injection of saline ovarian extract in complete Freund's adjuvant. The ovary, thymus, and spleen were investigated histologically, histoautoradiographically, and electromicroscopically on days 7, 14, 21, and 28 after immunization. EIO was manifested by massive atresia of follicles and perivascular mononuclear cell infiltration. The appearance of the germinal center like structures in the thymus and increased T cell mitotic activity and B cell stimulation in the spleen pointed out that EIO is mediated both by T and B cells.     

CONFORMATIONAL ANALYSIS OF N-(tert.-AMYLOXYCARBONY-l-PROLINE IN THE SOLID STATE AND IN SOLUTION

The solid-state conformational analysis of t-AOC-l -Pro-OH** has indicated that the molecules are not folded up to form an oxy-C₇ peptide conformation, but rather that they are held together through intermolecular O-H. 0 = C (urethane) hydrogen bonds. The tertiary amide bond is in the cis configuration. In solvents of high polarity strongly solvated species largely predominate. In cyclohexane solution non-associated and associated (involving the carboxyl C = O as the proton acceptor) species are simultaneously present. Obviously, the extent of association increases with increasing solute concentration. The amount of the oxy-C₇ form, if any, should be extremely small. It is also demonstrated that CD measurements alone can lead to an incorrect picture of the conformational preferences of amino acid derivatives and small peptides in solution.     

Trimethoprim-sulfamethoxazole-induced Cholestasis

A 52-year old woman developed severe cholestasis seven days after the administration of trimethoprim-sulfamethoxazole (TMP-SMZ) The clinical and pathologic features are discussed as well as the various mechanisms of liver injury following TMP-SMZ use.