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111.
Human alveolar macrophage phagocytic function is impaired by aggregates of ultrafine carbon particles. 总被引:3,自引:0,他引:3
Alveolar macrophages (AM) were collected by bronchoalveolar lavage from healthy volunteers. The AM were loaded with small masses (0.03-3 microg/10(6) AM) of ultrafine carbon particle aggregates. The phagocytic activity of the cells was studied 20 h after the loading. Fluorescein-labeled silica particles (3 microm) were used as test particles and the attachment and ingestion processes were studied separately. In some experiments, AM were incubated with interferon-gamma (IFN-gamma) for 20 h before and during the test of phagocytic activity and during measurement of oxidative metabolism. The ingested carbon particles induced a dose-related impairment of both the attachment and the ingestion processes with a marked impairment down to a carbon particle dose around 0.2 microg/10(6) AM. Such levels should reasonably occur after inhalation of existing concentrations of urban air particles, which to a considerable extent consist of aggregates of ultrafine particles with a carbon skeleton. Incubation with IFN-gamma (12.5 U/ml) also induced significant impairments in both the attachment and the ingestion processes. Loading with carbon further aggravated the effect of IFN-gamma. In contrast to earlier studies in rat AM, IFN-gamma did not impair the oxidative metabolism at rest in these human AM; instead the oxidative metabolism was increased. This difference was due to a difference between rat and human AM and not between rat and human IFN-gamma. Our results suggest that ingested environmental particles in AM, e.g., after an episode of high particle concentration, may impair phagocytic capacity of the cells, especially after infections that induce an increased production of IFN-gamma. Consequently, there might be a risk for additional infections. Moreover, inhaled particles not phagocytized by AM might damage the lung tissue. 相似文献
112.
Pham Thi Lan Cecilia St?lsby Lundborg Ingrid Mogren Ho Dang Phuc Nguyen Thi Kim Chuc 《BMC infectious diseases》2009,9(1):85
Background
The serious long-term complications of sexually transmitted infections (STI) in women and newborns are well-documented. Particularly, STI imply considerable social consequences for women. Low STI knowledge has been shown to be associated with unsafe sex. In Vietnam, misconceptions regarding STI exist, and rural women delay seeking care for STI. The aim of the study was to investigate knowledge of STI among women aged 15 to 49 years in a rural district of Vietnam and to evaluate possible associations between socioeconomic factors and STI knowledge. 相似文献113.
114.
Birgitta Rosén Anders Bj?rkman G?ran Lundborg 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2008,42(1):51-53
We report a case of neuropathy induced by vibration and compression in the hand of a dental hygienist. Her hand function was improved considerably by repeated treatment during which EMLA cream (EMLA cream is a local anaesthetic agent containing lidocain 2.5% and priolocain 2.5%) was applied to the forearm to induce cutaneous anaesthesia. 相似文献
115.
Edith Hunt Raleigh PhD RN Marybeth Lepczyk MSN RN CS Constance Rowley MEd RN 《Journal of advanced nursing》1990,15(8):941-945
Little attention has been given to the preparation of the patient's family prior to surgery, even though nurses' clinical experience suggests that family members are often more anxious than the patient. This study explored the knowledge and anxiety of spouses and significant others of patients preparing for cardiac surgery. The subjects were selected by convenience from a preoperative class offered at the hospital where surgery was to occur. Before and after the class, the subjects completed a cardiac-surgery knowledge test and an anxiety test. The significant others were significantly more anxious than the patients prior to the class. The anxiety level of significant others was significantly reduced after the class. There were no statistically significant differences between patients and significant others on the cardiac-surgery knowledge test. These results suggest that significant others may benefit from preoperative instruction. 相似文献
116.
117.
Nguyen Quynh Hoa Nguyen V Trung Mattias Larsson Bo Eriksson Ho D Phuc Nguyen TK Chuc Cecilia Stalsby Lundborg 《BMC infectious diseases》2010,10(1):85
Background
Streptococcus pneumoniae is the most significant bacterial cause of community-acquired pneumonia among children under five years worldwide. Updated resistance information of S. pneumoniae among children is essential to adjust the recommendations for empirical treatment of community-acquired pneumonia, which will have immense implications for local and global health. This study investigated the prevalence of antibiotic resistance in isolated strains of S. pneumoniae and relationship with antibiotic use and demographic factors of children under five in rural Vietnam in 2007. 相似文献118.
Q Zhao L B Dahlin M Kanje G Lundborg 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》1991,25(3):221-224
To study the effects of drying on regeneration, crush lesions were made on the sciatic nerve of 38 rats and the injured area was then air-dried for various periods of time (0-60 min). The regeneration distance of sensory nerve fibres was measured by the pinch reflex test three or six days later. Regeneration was significantly impaired by drying the nerve for 30 or 60 min, but shorter periods (10 min) also seemed to affect axonal outgrowth. Regeneration distances were increased in nerves that were subjected to drying and then allowed to recover for a week (conditioning interval) before the nerve was crushed. The results show that drying of a peripheral nerve is detrimental to nerve regeneration, and we suggest that nerves should not be exposed to air for more than a few minutes during operation without irrigation. 相似文献
119.
Summary In a randomised double-blind crossover study, seven healthy males were concomitantly given metoprolol 100 mg o. d. as a controlled release formulation, and omeprazole 40 mg o. d. or placebo, for 8 days. Plasma levels of the R- and S-enantiomers of metoprolol were determined on the 8th day of each treatment. The subjects were also characterised by their metabolic capacity to hydroxylate debrisoquine. Concomitant omeprazole treatment had no significant influence on the steady-state plasma levels of the two enantiomers of metoprolol. All subjects were characterised by extensive debrisoquine hydroxylation, i.e. extensive metoprolol metabolism.As metoprolol is metabolised to a great extent by debrisoquine hydroxylase (IID6), it is concluded that concomitant omeprazole treatment will probably have a negligible influence on the metabolism of the relatively large number of drugs mainly metabolised by this isoenzyme of the cytochrome P450 family. 相似文献
120.
Kathleen Ludwikowski MS RN CS Pediatric Nurse Practitioner owner Marcia DeValk BA RN C Child Adolescent Psychiatric Nurse Consultant 《Journal of child and adolescent psychiatric nursing》1998,11(1):17-29
TOPIC. Attention-deficitlhyperactivity disorder is frequently overdiagnosed when a complete evaluation by a knowledgeable clinician is not undertaken. Because of the recent negative media campaign regarding psychos t im ulan t medication, it becomes more imperative that a thorough and accurate evaluation be completed before starting children and adolescents on psychostimulant medications.
PURPOSE. To describe the neurodevelopmental perspective in the assessment and treatment of ADHD.
SOURCES. Published literature and clinical experience.
CONCLUSION. It is useful in practice to conceptualize the dmelopmental path of children with ADHD not as disordered but as delayed, and to build on each child's strengths. The neurodmeloprnental approach provides the child psychiatric nurse a child-focused framework for assessment and development of individualized interventions. 相似文献
PURPOSE. To describe the neurodevelopmental perspective in the assessment and treatment of ADHD.
SOURCES. Published literature and clinical experience.
CONCLUSION. It is useful in practice to conceptualize the dmelopmental path of children with ADHD not as disordered but as delayed, and to build on each child's strengths. The neurodmeloprnental approach provides the child psychiatric nurse a child-focused framework for assessment and development of individualized interventions. 相似文献