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排序方式: 共有1752条查询结果,搜索用时 15 毫秒
71.
Díaz JM Sainz Z Gich I Guirado LL Puig T Oliver A Montañés R Chuy E Solà R 《Transplantation proceedings》2005,37(9):3799-3801
Hyperhomocysteinemia (hyperHcy) is one cardiovascular risk. The objective of this study was to establish the prevalence demographic, and clinical and analytical factors related to hyperhomocysteinemia among renal transplant patients. The mean Hcy level was 17.3 micromol/L; the prevalence of hyperHcy was 61.2%. The population was categorized as hyperHcy and normal-homocysteinemia (Hcy) patients. Those subjects with hyperHcy were mostly men, with lower intraerythrocyte folate and vitamin B(12) levels, higher fibrinogen levels, and poorer renal function. Multivariate evaluation showed that creatinine clearance, plasma intraerythrocyte folate and vitamin B(12) levels, and plasma fibrinogen levels were independently associated with Hcy levels. Even though the Hcy level was slightly higher among patients who suffered a posttransplantation cardiovascular event, this was statistically significant. 相似文献
72.
de la Fuente de Hoz L Brugal Puig MT Ballesta Gómez R Bravo Poetela MJ Barrio Anta G Domingo Salvany A Silva do Rosario T Ambrós Hortensi M;Grupo del proyecto ITINERE 《Revista espa?ola de salud pública》2005,79(4):475-491
BACKGROUND: Cohort studies make it possible to monitor the health impact of drug use and to identify related factors. We describe the methodology and baseline characteristics of a cohort of heroin users designed with this objective. METHODS: The participants were 991 young, community-recruited heroin users in Barcelona, Madrid and Seville. Most subjects were named by other participants (39.7%) or by non-participating drug users or ex-users (44.7%). A computer-aided questionnaire was administered (self-administered with audio for questions related with sex). A dried-blood spot sample was collected and anthropometric measurements were made. Both participants and recruiters received remuneration. Univariate and bivariate statistical methods were used. RESULTS: Some 42.4% had changed the main route of heroin administration, mainly to injection in Barcelona and to the pulmonary route in Seville. About 75.8% (Barcelona), 49.8% (Madrid), and 15.5% (Seville) had injected drugs in the last 12 months. In Madrid and Seville, 96-97% used heroin in base form, while in Barcelona heroin hydrochloride predominated. Heroin and cocaine were frequently mixed in the same dose (generally base cocaine in Madrid and Seville, and cocaine hydrochloride in Barcelona). CONCLUSIONS: Important geographic differences persist in the prevalence of drug injection and in the patterns of heroin and cocaine use, which could explain the unequal distribution of some health problems. The difficulties encountered in recruiting the sample suggest that the incidence of heroin use has declined considerably. 相似文献
73.
A procedure-specific systematic review and consensus recommendations for postoperative analgesia following laparoscopic cholecystectomy 总被引:1,自引:0,他引:1
Kehlet H Gray AW Bonnet F Camu F Fischer HB McCloy RF Neugebauer EA Puig MM Rawal N Simanski CJ 《Surgical endoscopy》2005,19(10):1396-1415
Background: Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain. However, a systematic review of
postoperative pain management in this procedure has not been conducted.
Methods: A systematic review was conducted according to the guidelines of the Cochrane Collaboration. Randomized studies examining
the effect of medical or surgical interventions on linear pain scores in patients undergoing laparoscopic cholecystectomy
were included. Qualitative and quantitative analyses were performed. Recommendations for patient care were derived from review
of these data, evidence from other relevant procedures, and clinical practice observations collated by the Delphi method among
the authors.
Results: Sixty-nine randomized trials were included and 77 reports were excluded. Recommendations are provided for preoperative analgesia,
anesthetic and operative techniques, and intraoperative and postoperative analgesia.
Conclusions: A step-up approach to the management of postoperative pain following laparoscopic cholecystectomy is recommended. This approach
has been designed to provide adequate analgesia while minimizing exposure to adverse events.
This material was presented in part as abstracts at the Euroanaesthesia Congress in Glasgow, Scotland, 2003 相似文献
74.
75.
Las Heras Alonso MM Pérez Ruiz L Guajardo Guajardo J Bordalba Gómez JR Puig Giró R Gómez Agudo M Flavian Domenech LM Berbegal C 《Actas urologicas espa?olas》2005,29(3):292-295
We documented the frequency of nephritic colic in patients with primary hyperparathyroidism, and determined its modification after the parathyroidectomy; we also studied laboratory parameters such as calcium, phosphorus and parathyroid hormone in serum, and the excretion of Cao 24h, previous and later to the intervention. At sight of the results it is possible to be concluded that the parathyroidectomy is useful in the treatment of the kidney stone disease produced by the primary hyperparathyroidism. 相似文献
76.
Several techniques have been advocated for knee arthrodesis, and there has been an increasing interest in modular intramedullary nails in the recent last years. We report a case of femoral and tibial fractures at each end of a modular nail in a solidly fused knee 8 months after an arthrodesis. 相似文献
77.
Ferrer I Barrachina M Puig B Martínez de Lagrán M Martí E Avila J Dierssen M 《Neurobiology of disease》2005,20(2):392-400
DYRK1A, dual-specificity tyrosine-regulated kinase 1A, maps to human chromosome 21 within the Down syndrome (DS) critical region. Dyrk1 phosphorylates the human microtubule-associated protein tau at Thr212 in vitro, a residue that is phosphorylated in fetal tau and hyper-phosphorylated in Alzheimer disease (AD) and tauopathies, including Pick disease (PiD). Furthermore, phosphorylation of Thr212 primes tau for phosphorylation by glycogen synthase kinase 3 (GSK-3). The present study examines Dyrk1A in the cerebral cortex of sporadic AD, adult DS with associated AD, and PiD. Increased Dyrk1A immunoreactivity has been found in the cytoplasm and nuclei of scattered neurons of the neocortex, entorhinal cortex, and hippocampus in AD, DS, and PiD. Dyrk1A is found in sarkosyl-insoluble fractions which are enriched in phosphorylated tau in AD brains, thus suggesting a possible association of Dyrk1A with neurofibrillary tangle pathology. Yet, no clear relationship has been observed between tau phosphorylation at Thr212, and GSK-3 and Dyrk1A expression in diseased brains. Transgenic mice bearing a triple tau mutation (G272V, P301L, and R406W) and expressing hyper-phosphoyrylated tau in neurons of the entorhinal cortex, hippocampus, and cerebral neocortex show increased expression of Dyrk1A in individual neurons in the same regions. However, transgenic mice over-expressing Dyrk1A do not show increased phosphorylation of tau at Thr212, thus suggesting that Dyrk1A over-expression does not trigger per se hyper-phosphorylation of tau at Thr212 in vivo. The present observations indicate modifications in the expression of constitutive Dyrk1A in the cytoplasm and nuclei of neurons in various neurodegenerative diseases associated with tau phosphorylation. 相似文献
78.
Schretlen DJ Ward J Meyer SM Yun J Puig JG Nyhan WL Jinnah HA Harris JC 《Developmental medicine and child neurology》2005,47(10):673-677
Self-injury is a defining feature of lesch-nyhan disease (LND) but does not occur in the less severely affected Lesch-Nyhan variants (LNV). The aim of this study was to quantify behavioral and emotional abnormalities in LND and LNV. Thirty-nine informants rated 22 patients with LND (21 males, 1 female), 11 males with LNV, and 11 healthy controls (HC; 10 males, 1 female) using two well-validated rating scales. The age of patients with LND ranged from 12 years 7 months to 38 years 3 months (mean 22 y 11 mo; sd 7 y 8 mo), whereas the age range of those with LNV was 12 years 9 months to 65 years (mean 30 y 7 mo; sd 15 y 2 mo), and the healthy controls were aged 12 years 4 months to 31 years 3 months (mean 17 y 10 mo; sd 5 y 7 mo). Behavioral ratings were based on the Child Behavior Checklist and the American Association On Mental Retardation's Adaptive Behavior Scale--Residential And Community, 2nd edition. Statistical analyses revealed that patients with LND showed severe self-injury together with problematic aggression, anxious-depressed symptoms, distractibility, motor stereotypes, and disturbing interpersonal behaviors. Patients with LNV were rated as being intermediate between the HC and LND groups on all behavior scales. Although the LNV group did not differ from hcs on most scales, their reported attention problems were as severe as those found in LND. We conclude that self-injurious and aggressive behaviors are nearly universal and that other behavioral abnormalities are common in LND. Although patients with LNV typically do not self-injure or display severe aggression, attention problems are common and a few patients demonstrate other behavioral anomalies. 相似文献
79.
80.