全文获取类型
收费全文 | 1589篇 |
免费 | 149篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 44篇 |
妇产科学 | 27篇 |
基础医学 | 129篇 |
口腔科学 | 6篇 |
临床医学 | 153篇 |
内科学 | 294篇 |
皮肤病学 | 335篇 |
神经病学 | 121篇 |
特种医学 | 90篇 |
外科学 | 235篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 81篇 |
眼科学 | 11篇 |
药学 | 104篇 |
中国医学 | 2篇 |
肿瘤学 | 99篇 |
出版年
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 31篇 |
2020年 | 40篇 |
2019年 | 42篇 |
2018年 | 51篇 |
2017年 | 54篇 |
2016年 | 40篇 |
2015年 | 41篇 |
2014年 | 57篇 |
2013年 | 85篇 |
2012年 | 80篇 |
2011年 | 68篇 |
2010年 | 54篇 |
2009年 | 50篇 |
2008年 | 67篇 |
2007年 | 84篇 |
2006年 | 77篇 |
2005年 | 94篇 |
2004年 | 77篇 |
2003年 | 64篇 |
2002年 | 81篇 |
2001年 | 58篇 |
2000年 | 61篇 |
1999年 | 54篇 |
1998年 | 15篇 |
1997年 | 11篇 |
1996年 | 18篇 |
1995年 | 16篇 |
1994年 | 9篇 |
1993年 | 5篇 |
1992年 | 22篇 |
1991年 | 28篇 |
1990年 | 29篇 |
1989年 | 32篇 |
1988年 | 25篇 |
1987年 | 19篇 |
1986年 | 17篇 |
1985年 | 9篇 |
1984年 | 10篇 |
1981年 | 4篇 |
1979年 | 8篇 |
1977年 | 7篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1972年 | 6篇 |
1971年 | 7篇 |
1970年 | 3篇 |
1968年 | 3篇 |
排序方式: 共有1747条查询结果,搜索用时 640 毫秒
101.
102.
103.
104.
105.
106.
Oliveras A Vázquez S Hurtado S Vila J Puig JM Lloveras J 《Transplantation proceedings》2004,36(5):1352-1354
BACKGROUND: Hypertension (HT) accounts for nearly 60% to 80% of renal transplant patients (RT). It is one of the most important risk factors for cardiovascular diseases and may cause chronic graft dysfunction. Therefore, it is important to accurately detect and treat HT. We aimed to evaluate the changes in ambulatory blood pressure monitoring (ABPM) parameters among hypertensive RT after active treatment compared with baseline values. METHODS: Thirty seven RT (25 men, 12 women, aged 49.4 +/- 11.2 year) diagnosed with mild to moderate HT underwent 24-hour ABPM after a 4-week washout period (W0). For the 23 RT with confirmed HT of a second 24-hour ABPM was recorded after 4 weeks of treatment with doxazosin GITS (-4 mg once daily in the morning), a new formulation of an alpha1-receptor inhibitor (W4). Nondippers were considered when mean blood pressure (BP) showed a < or = 10% reduction during sleep. Statistical analyses included Saphiro-Wilks test, Student t test, and ANOVA. RESULTS: After active treatment systolic, diastolic, and mean BP (SBP, DBP, MBP) significantly decreased during diurnal and 24 hours but not the nocturnal period. No significant change was observed for heart rate nor for pulse pressure during any period. The prevalence dippers increased from 0% to 17% after treatment. After placebo administration 8 among 37 RT with HT diagnosed according to casual BP remained hypertensive at nighttime (but not at daytime) according to 24-hour ABPM. CONCLUSIONS: Diurnal and 24-hour periods of ABPM showed significant changes in SBP, DBP, and MBP after active treatment with doxazosin GITS. No significant BP changes were observed in the nocturnal period or in dipper status. Further studies using ABPM must be undertaken to determine the optimal dosage and time of administration of antihypertensive drugs in RT. 相似文献
107.
De Oliveira SA Lisboa LA Dallan LA Puig LB Succi GM Abreu Filho CA 《The heart surgery forum》2004,7(1):22-26
Abstract Background: We describe our experience with the limited left thoracotomy strategy for reoperative coronary artery bypass graft (CABG)to the circumflex coronary artery system, emphasizing the indications, our particular operative technique, and early clinical follow-up. Methods: From January 2001 to January 2002, 8 consecutive patients underwent redo revascularization via limited left thoracotomy and without cardiopulmonary bypass. This operation was indicated for patients with recurrent myocardial ischemia confined to the lateral wall of the left ventricle, especially if a patent left internal thoracic artery (LITA)-to-left anterior descending coronary artery (LAD)graft was present. Results: All 8 patients underwent successful redo revascularization via limited left thoracotomy. Eight patients received 14 saphenous vein grafts (mean 1.7 grafts/patient). No instances of postoperative myocardial infarction or death occurred. During a follow-up period ranging from 1 to 12 months (mean, 5. 2 months), all patients were asymptomatic and without evidence of ischemia or infarction. Conclusions: For select patients who have patent LITA grafted into the LAD and who need redo CABG to the coronary artery circumflex system, the limited left thoracotomy approach without cardiopulmonary bypass is a safe operation and a less invasive alternative to repeat sternotomy and conventional CABG. 相似文献
108.
Puig Junoy J 《Revista de enfermería (Barcelona, Spain)》2004,27(7-8):66-68
The scarce integration and coordination of treatment is considered to be a very important problem in our health system. Can capitation, which means something like "charging a fee on each citizen based on his/her treatment necessities" resolve this problem? Can capitation favor clinical and treatment integration? 相似文献
109.
Fonquerna S Miralpeix M Pagès L Puig C Cardús A Antón F Cárdenas A Vilella D Aparici M Calaf E Prieto J Gras J Huerta JM Warrellow G Beleta J Ryder H 《Journal of medicinal chemistry》2004,47(25):6326-6337
A series of indolylpiperidinyl derivatives were prepared and evaluated for their activity as histamine H(1) antagonists. Structure-activity relationship studies were directed toward improving in vivo activity and pharmacokinetic profile of our first lead (1). Substitution of fluorine in position 6 on the indolyl ring led to higher in vivo activity in the inhibition of histamine-induced cutaneous vascular permeability assay but lower selectivity toward 5HT(2) receptor. Extensive optimization was carried out within this series and a number of histamine H(1) antagonists showing potency and long duration of action in vivo and low brain penetration or cardiotoxic potential were identified. Within this novel series, indolylpiperidines 15, 20, 48,51 and 52 exhibited a long half-life in rat and have been selected for further preclinical evaluation. 相似文献
110.