全文获取类型
收费全文 | 1766篇 |
免费 | 100篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 36篇 |
妇产科学 | 78篇 |
基础医学 | 182篇 |
口腔科学 | 31篇 |
临床医学 | 143篇 |
内科学 | 470篇 |
皮肤病学 | 29篇 |
神经病学 | 178篇 |
特种医学 | 44篇 |
外科学 | 231篇 |
综合类 | 4篇 |
预防医学 | 86篇 |
眼科学 | 16篇 |
药学 | 198篇 |
中国医学 | 7篇 |
肿瘤学 | 140篇 |
出版年
2024年 | 1篇 |
2023年 | 16篇 |
2022年 | 30篇 |
2021年 | 57篇 |
2020年 | 33篇 |
2019年 | 48篇 |
2018年 | 54篇 |
2017年 | 45篇 |
2016年 | 49篇 |
2015年 | 69篇 |
2014年 | 73篇 |
2013年 | 89篇 |
2012年 | 148篇 |
2011年 | 144篇 |
2010年 | 75篇 |
2009年 | 63篇 |
2008年 | 107篇 |
2007年 | 115篇 |
2006年 | 108篇 |
2005年 | 113篇 |
2004年 | 78篇 |
2003年 | 103篇 |
2002年 | 79篇 |
2001年 | 18篇 |
2000年 | 20篇 |
1999年 | 19篇 |
1998年 | 17篇 |
1997年 | 8篇 |
1996年 | 11篇 |
1995年 | 9篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 15篇 |
1991年 | 10篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 8篇 |
1987年 | 10篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1983年 | 5篇 |
1982年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有1881条查询结果,搜索用时 15 毫秒
991.
992.
Alberto InuggiNinfa Amato Giuseppe MagnaniJavier J. González-Rosa Raffaella ChieffoGiancarlo Comi Letizia Leocani 《Neurobiology of aging》2011,32(3):524-538
Normal aging is associated with several modifications in the cerebral motor system that reflect into an increased and more bilateral activation in elderly subjects. Twelve young and nine elderly healthy right-handed subjects performed a self-initiated brisk right thumb extension while recorded with 32-channel EEG. The aging effect over cortical generators of bereithshaftspotential, reconstructed using cortical current density (CCD) method and a realistic volume conductor, was evaluated in five different periods and in both mesial and lateral motor-related areas. Over-activation occurred mainly at movement initiation in those areas related to simple movements (caudal mesial areas and both sensorimotor cortices) and in contralateral sensorimotor cortex during the post-movement phase. In those areas, the elderly group recruited a larger neuronal population than the young one in the presence of a significantly longer movement. This more likely suggests their reduced selectivity in activating the motor cortex than a compensatory mechanism to produce an optimum performance. Movement duration resulted negatively correlated with pre-SMA activity, suggesting its involvement in movement termination. 相似文献
993.
Alvisa Palese Barbara Trevisani Annamaria Guarnier Paolo Barelli Paola Zambiasi Elisabetta Allegrini Letizia Bazoli Paola Casson Meri Marin Marisa Padovan Michele Picogna Patrizia Taddia Daniele Salmaso Paolo Chiari Oliva Marognolli Canzan Federica Luisa Saiani Elisa Ambrosi 《Journal of tissue viability》2017,26(2):85-88
To describe the prevalence and incidence density of hospital-acquired unavoidable pressure sores among patients aged ≥65 years admitted to acute medical units. A secondary analysis of longitudinal study data collected in 2012 and 2013 from 12 acute medical units located in 12 Italian hospitals was performed. Unavoidable pressure ulcers were defined as those that occurred in haemodynamically unstable patients, suffering from cachexia and/or terminally ill and were acquired after hospital admission. Data at patient and at pressure ulcer levels were collected on a daily basis at the bedside by trained researchers. A total of 1464 patients out of 2080 eligible (70.4%) were included. Among these, 96 patients (6.5%) hospital-acquired a pressure ulcer and, among 19 (19.7%) were judged as unavoidable. The incidence of unavoidable pressure ulcer was 8.5/100 in hospital-patient days. No statistically significant differences at patient and pressure ulcers levels have emerged between those patients that acquired unavoidable and avoidable pressure sores. Although limited, evidence on unavoidable pressure ulcer is increasing. More research in the field is recommended to support clinicians, managers and policymakers in the several implications of unavoidable pressure ulcers both at the patient and at the system levels. 相似文献
994.
The degree of satisfaction of in‐hospital medical patients with nursing care and predictors of dissatisfaction: findings from a secondary analysis
下载免费PDF全文
![点击此处可从《Scandinavian journal of caring sciences》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Alvisa Palese MNS Silvia Gonella MNS Anna Fontanive BNS Annamaria Guarnier MNS Paolo Barelli MNS Paola Zambiasi MNS Elisabetta Allegrini MNS Letizia Bazoli MNS Paola Casson MNS Meri Marin MNS Marisa Padovan MNS Michele Picogna MNS Patrizia Taddia MNS Daniele Salmaso MNS Paolo Chiari MNS Tiziana Frison MNS Oliva Marognolli MNS Federica Canzan PhD Elisa Ambrosi PhD Luisa Saiani MNS ESAMED Group 《Scandinavian journal of caring sciences》2017,31(4):768-778
995.
996.
997.
Letizia Muccio Alice Bertaina Michela Falco Daniela Pende Raffaella Meazza Miguel Lopez-Botet Lorenzo Moretta Franco Locatelli Alessandro Moretta Mariella Della Chiesa 《Haematologica》2016,101(3):371-381
We analyzed the impact of human cytomegalovirus infection on the development of natural killer cells in 27 pediatric patients affected by hematological malignancies, who had received a HLA-haploidentical hematopoietic stem cell transplantation, depleted of both α/β+ T cells and B cells. In line with previous studies in adult recipients of umbilical cord blood transplantation, we found that human cytomegalovirus reactivation accelerated the emergence of mature natural killer cells. Thus, most children displayed a progressive expansion of a memory-like natural killer cell subset expressing NKG2C, a putative receptor for human cytomegalovirus, and CD57, a marker of terminal natural killer cell differentiation. NKG2C+CD57+ natural killer cells were detectable by month 3 following hematopoietic stem cell transplantation and expanded until at least month 12. These cells were characterized by high killer Ig-like receptors (KIRs) and leukocyte inhibitory receptor 1 (LIR-1) and low Siglec-7, NKG2A and Interleukin-18Rα expression, killed tumor targets and responded to cells expressing HLA-E (a NKG2C ligand). In addition, they were poor Interferon-γ producers in response to Interleukin-12 and Interleukin-18. The impaired response to these cytokines, together with their highly differentiated profile, may reflect their skewing toward an adaptive condition specialized in controlling human cytomegalovirus. In conclusion, in pediatric patients receiving a type of allograft different from umbilical cord blood transplantation, human cytomegalovirus also induced memory-like natural killer cells, possibly contributing to controlling infections and reinforcing anti-leukemia effects. 相似文献
998.
Buommino E De Filippis A Nicoletti R Menegozzo M Menegozzo S Ciavatta ML Rizzo A Brancato V Tufano MA Donnarumma G 《Investigational new drugs》2012,30(4):1343-1351
Malignant pleural mesothelioma is a fatal malignancy linked to asbestos exposure. The main challenge for mesothelioma treatment is to go beyond the drug resistance, in particular against cisplatin (CDDP), one of the most used chemotherapeutic drug. 3-O-methylfunicone (OMF) is a metabolite produced by the fungus Penicillium pinophilum; its antiproliferative properties have been previously studied in vitro. Particularly, OMF is able to inhibit mesothelioma cell motility. To improve the effects of CDDP by-passing the resistance of mesothelioma cells to this drug, in the present study we investigated the combined treatment of OMF with CDDP respectively in an established mesothelioma cell line (NCI) and primary mesothelioma cells (Mest). As compared to the effect of single treatments, the combination of OMF and CDDP resulted in a stronger inhibition of NCI and Mest cell proliferation. OMF combination with CDDP was also able to affect the migratory ability of NCI and Mest cells by down-regulating αv and β5 expression and reducing metalloproteinase 2 (MMP-2) production. In addition, this association was effective in modulating VEGF gene expression. This finding highlights the possibility to use OMF and CDDP together to regulate angiogenesis and tumour progression in mesothelioma. 相似文献
999.
Musumeci ML Schlecht K Perrotta R Schwartz RA Micali G 《Cutis; cutaneous medicine for the practitioner》2008,81(4):315-322
Cutaneous hemangiomas (CHs) are common benign vascular tumors of childhood. Clinically, they are characterized by a typical evolution profile, consisting of a rapid proliferation during the first year of life and slow involution that usually is completed by 5 to 10 years of age. In most cases, no treatment is necessary. However, when CHs are located in areas at risk for functional complications; are of considerable size; or repeatedly undergo bleeding, ulceration, or superinfection, a prompt and adequate treatment approach is required. First-line approaches include topical, intralesional, and systemic corticosteroids. Second-line options include interferon alfa-2a and -2b, laser therapy, and surgical therapy. Third-line approaches include cytotoxins, embolization, and angiogenesis inhibitors. Other therapies and procedural approaches including intermittent pneumatic and continuous compression; cryosurgery; radiotherapy; implantation of copper needles; sclerotherapy; electrocautery; electroacupuncture; imiquimod cream 5%; and prospective agents, such as OXi4503 (diphosphate prodrug of combretastatin A1) and cidofovir, are discussed. Treatment options for ulcerated CHs also are described. 相似文献
1000.
Barros LM Boriollo MF Alves AC Klein MI Gonçalves RB Höfling JF 《Archives of oral biology》2008,53(12):1172-1178