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排序方式： 共有981条查询结果，搜索用时 221 毫秒
31.
32.
Coakley G; Mok CC; Hajeer AH; Ollier WE; Turner D; Sinnott PJ; Hutchinson IV; Panayi GS; Lanchbury JS 《Rheumatology (Oxford, England)》1998,37(9):988-991
OBJECTIVE: To examine whether promoter polymorphisms associated with
variation in interleukin-10 (IL-10) production are relevant to the
development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS:
DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The
promoter region between -533 and - 1120 was amplified by polymerase chain
reaction, and polymorphisms detected by restriction enzyme digest or
sequence-specific oligonucleotide probing. RESULTS: We found no significant
difference in allele or haplotype frequencies between the groups.
CONCLUSION: There is no association between FS or RA and these recently
identified IL-10 promoter polymorphisms. Other genetic or environmental
factors could explain the alterations in IL-10 levels seen in these
conditions.
相似文献
33.
Effects of electroacupuncture on gastric mucosal blood flow and transmucosal potential difference in stress rats 总被引：9，自引：0，他引：9
ＥｆｅｃｔｓｏｆｅｌｅｃｔｒｏａｃｕｐｕｎｃｔｕｒｅｏｎｇａｓｔｒｉｃｍｕｃｏｓａｌｂｌｏｏｄｆｌｏｗａｎｄｔｒａｎｓｍｕｃｏｓａｌｐｏｔｅｎｔｉａｌｄｉｆｅｒｅｎｃｅｉｎｓｔｒｅｓｓｒａｔｓＸＵＧｕａｎＳｕｎ１，ＳＵＮＹｏｎｇ１，ＷＡＮＧＺｈｅ... 相似文献
34.
Anne S. Chin Martin J. Willemink Aya Kino Virginia Hinostroza Anna M. Sailer Michael P. Fischbein R. Scott Mitchell Gerald J. Berry D. Craig Miller Dominik Fleischmann 《Journal of the American College of Cardiology》2018,71(24):2773-2785
Background
Limited intimal tears (LITs) of the aorta (Class 3 dissection variant) are the least common form of aortic pathology in patients presenting with acute aortic syndrome (AAS). LITs are difficult to detect on imaging and may be underappreciated.Objectives
This study sought to describe the frequency, pathology, treatment, and outcome of LITs compared with other AAS, and to demonstrate that LITs can be detected pre-operatively by contemporary imaging.Methods
The authors retrospectively reviewed 497 patients admitted for 513 AAS events at a single academic aortic center between 2003 and 2012. AAS were classified into classic dissection (AD), intramural hematoma, LIT, penetrating atherosclerotic ulcer, and rupturing thoracic aortic aneurysm. The prevalence, pertinent risk factors, and detailed imaging findings with surgical and pathological correlation of LITs are described. Management, early outcomes, and late mortality are reported.Results
Among 497 patients with AAS, the authors identified 24 LITs (4.8% of AAS) in 16 men and 8 women (17 type A, 7 type B). Patients with LITs were older than those with AD, and type A LITs had similarly dilated ascending aortas as type A AD. Three patients presented with rupture. Eleven patients underwent urgent surgical aortic replacement, and 2 patients underwent endovascular repair. Medial degeneration was present in all surgical specimens. In-hospital mortality was 4% (1 of 24), and in total, 5 patients with LIT died subsequently at 1.5 years (interquartile range [IQR]: 0.3 to 2.5 years). Computed tomography imaging detected all but 1 LIT, best visualized on volume-rendered images.Conclusions
LITs are rare acute aortic lesions within the dissection spectrum, with similar presentation, complications, and outcomes compared with AD and intramural hematoma. Awareness of this lesion allows pre-operative diagnosis using high-quality computed tomography angiography. 相似文献35.
Nicolas C. Nicolaides Agaristi Lamprokostopoulou Alexandros Polyzos Tomoshige Kino Eleni Katsantoni Panagiota Triantafyllou Athanasios Christophoridis George Katzos Maria Dracopoulou Amalia Sertedaki George P. Chrousos Evangelia Charmandari 《European journal of clinical investigation》2015,45(12):1306-1315
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Shin-ichiro Fujiwara Naohito Fujishima Heiwa Kanamori Masumi Ito Tatsuya Sugimoto Shoko Saito Takeshi Sakaguchi Koichi Nagai Hidekazu Masuoka Kazuhiro Nagai Akie Morita Shuichi Kino Asashi Tanaka Yuichi Hasegawa Akihiko Yokohama Keizo Fujino Shigeyoshi Makino Mayumi Matsumoto Kazuo Muroi 《Transfusion and apheresis science》2018,57(6):746-751
Background
Plasma removal by washing is an effective approach to prevent transfusion reactions by platelet concentrates (PCs). Recently, washed PCs were released by the Japanese Red Cross Society (JRCS).Materials and methods
This retrospective multicenter study evaluated the efficacy and safety of released washed PCs (RWPCs) between September 2016 and January 2017 in Japan. The RWPCs were prepared by washing leukoreduced apheresis PCs with the platelet additive solution, BRS-A, using automated cell processors.Results
Clinical data were obtained from 91 patients and 1210 RWPC transfusions at 50 institutions. The median number of RWPC transfusions per patient was 8 (range, 1–91). RWPCs were used in 94.5% of the patients with a history of recurrent or severe transfusion reactions for preventing such reactions. Responses of RWPCs were evaluated as complete response (91.6%), partial response (8.2%), no-change (0.2%), and progression (0%) and overall response was equal across subgroups divided by patients’ profiles. The median corrected count increment (CCI) at 1 and 24?h post-transfusion were 13.5 (range, 1.9–35.4)?×?109/L and 3.5 (range, ?13 to 53.6)?×?109/L, respectively, and median CCI at 24?h was 5.5 (range, ?13 to 53.6)?×?109/L in patients without risk factors associated with platelet transfusion refractoriness. Transfusion reactions to RWPCs were observed in only nine transfusions (0.7%), all of which were mild allergic reactions.Conclusion
This study demonstrated that RWPCs were effective and safe in patients with a history of transfusion reactions. Further prospective studies on efficacy together with cost-benefit analysis in RWPCs are needed. 相似文献40.
Atsuo Kitano Kenzo Kobayashi Hiroo Furukawa Yasutake Yamamoto Keiichi Kawai Susumu Morikawa Yoshiaki Maeda Tsuyoshi Tajima Haruki Wakasa Tadashi Yamazaki Tetsuichiro Muto Isamu Kino Hikaru Watanabe Nobuo Hiwatashi Hikoo Shirakabe Kyoichi Nakamura Noritsugi Ikeda Takanori Matsumura Moriya Yamashiro Shuji Tsuchiya Hiroshi Takemura Takeo Miyake Masami Oishi Tsuyoshi Suzaki Nobuhiro Sakaki Yukinori Okazaki Tokio Ono Michio Tanaka Shigeru Suzuki Masahiro Tada Yoshimasa Suto Shigeo Kobayashi Mamoru Nishizawa 《Journal of gastroenterology》1978,13(5):401-410