全文获取类型
收费全文 | 1805篇 |
免费 | 111篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 41篇 |
妇产科学 | 27篇 |
基础医学 | 278篇 |
口腔科学 | 24篇 |
临床医学 | 80篇 |
内科学 | 418篇 |
皮肤病学 | 50篇 |
神经病学 | 141篇 |
特种医学 | 25篇 |
外科学 | 472篇 |
综合类 | 7篇 |
预防医学 | 23篇 |
眼科学 | 20篇 |
药学 | 86篇 |
中国医学 | 1篇 |
肿瘤学 | 239篇 |
出版年
2023年 | 18篇 |
2022年 | 19篇 |
2021年 | 41篇 |
2020年 | 31篇 |
2019年 | 38篇 |
2018年 | 58篇 |
2017年 | 49篇 |
2016年 | 49篇 |
2015年 | 63篇 |
2014年 | 81篇 |
2013年 | 74篇 |
2012年 | 101篇 |
2011年 | 129篇 |
2010年 | 69篇 |
2009年 | 56篇 |
2008年 | 110篇 |
2007年 | 107篇 |
2006年 | 104篇 |
2005年 | 99篇 |
2004年 | 104篇 |
2003年 | 80篇 |
2002年 | 58篇 |
2001年 | 16篇 |
2000年 | 11篇 |
1999年 | 36篇 |
1998年 | 22篇 |
1997年 | 25篇 |
1996年 | 21篇 |
1995年 | 13篇 |
1994年 | 16篇 |
1993年 | 16篇 |
1992年 | 26篇 |
1991年 | 28篇 |
1990年 | 19篇 |
1989年 | 16篇 |
1988年 | 13篇 |
1987年 | 16篇 |
1986年 | 14篇 |
1985年 | 13篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1973年 | 5篇 |
1972年 | 4篇 |
1971年 | 3篇 |
排序方式: 共有1936条查询结果,搜索用时 906 毫秒
31.
Yurie Otsuru Chuichi Kondo Shohei Hara Hideo Takahashi Kenjiro Matsuno 《Anatomical science international / Japanese Association of Anatomists》2018,93(3):394-399
A unilateral megaureter was found in an elderly female cadaver during routine dissection. The left proximal ureter, which was thick and convolute, descended and entered into the pelvic cavity, where the distal ureter was attached to the posterior pelvic wall at the inlet level. Removal of connective tissue surrounding the attached region revealed ureteric entrapment in the sacroiliac joint. The ipsilateral kidney, from which the megaureter originated, showed no pelvicalyceal dilatation. In contrast, the left kidney was enlarged, weighing 24% more than the right kidney. Differences in the upper urinary system between the obstructed and normal sides were examined in terms of gross anatomy, measurements, and histology. Although ureteric obstruction frequently causes hydroureter and hydronephrosis, the present case is very rare as the incomplete obstruction may have stimulated ipsilateral kidney growth, instead of contralateral compensatory augmentation. 相似文献
32.
Clinical impact of surveillance colonoscopy using magnification without diminutive polyp removal 下载免费PDF全文
33.
34.
Novel ex vivo training model for freehand insertion using a double‐bending peroral direct cholangioscope 下载免费PDF全文
35.
Miyu Sekio Kenjiro Seki 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2015,18(1)
Background:
Chronic stress-induced depressive-like behavior is relevant to inflammatory immune activation. However, the neurobiological alterations in the brain following the central inflammatory immune activation remain elusive.Methods:
Therefore, we investigated the neurobiological alterations during depressive-like behavior induced in mice by systemic administration of lipopolysaccharide (LPS; 1.2mg/kg administered twice at a 30-min interval via intraperitoneal injection).Results:
At 24h after the second administration of LPS, an increased immobility time in the tail suspension test and the forced swimming test were observed, as well as reduced sucrose preference. Protein levels of the AMPA receptor GluR1 were significantly decreased at the plasma membrane in the medial prefrontal cortex (mPFC) and ventral tegmental area (VTA), while levels of the GluR2 were increased at the plasma membrane in the nucleus accumbens (NAc) at 24h after LPS. However, total GluR1 and GluR2 protein levels in the mPFC, VTA, and NAc were not affected by LPS. Moreover, LPS facilitated release of noradrenaline in the mPFC and VTA, but not in the NAc. Consistently, systemic administration of prazosin, an α1-adrenoceptor antagonist, blocked the LPS-induced downregulation of the membrane GluR1 subunit in both the mPFC and VTA and also blocked the upregulation of the membrane GluR2 subunit in the NAc. Intracerebroventricular administration of prazosin 30min before LPS injection abrogated the LPS-induced depressive-like behaviors. In opposition, administration of propranolol, a β-adrenoceptor antagonist, did not affect the LPS-induced downregulation of GluR1, the upregulation of GluR2, or the depressive-like behavior.Conclusions:
These results suggest that LPS-activated α1-adrenoceptor-induced downregulation of membrane GluR1 in the mPFC and VTA is associated with inflammation-induced depressive-like behavior. 相似文献36.
Shinobu Osanai Toru Takahashi Hiroyuki Enomoto Nobuyuki Satoh Osamu Yahara Yuji Akiba Satoru Fujiuchi Hitoshi Nakano Yoshinobu Ohsaki and Kenjiro Kikuchi 《Respirology (Carlton, Vic.)》2001,6(2):163-166
We describe a case of a 21-year-old man with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) who presented with hypoxic ventilatory depression. He had chronic hypoventilation, which was not explained by weakness of respiratory muscles. His hypercapnic ventilatory response was not impaired. In contrast, hypoxic ventilatory depression was observed in the isocapnic progressive hypoxic response test. After exposure to hypoxic conditions, his respiratory frequency decreased and tidal volume was unchanged. The hypoxic ventilatory depression was partially blocked by pretreatment with aminophylline. In conclusion, we need to be careful with patients with MELAS who are hypoxaemic because a vicious circle of hypoxia and hypoventilation can occur. 相似文献
37.
We report on a Japanese boy with Noonan syndrome who had short stature, bilateral cryptorchidism, poor pubertal development, mild mental retardation, complex cardiac lesions consisting of hypertrophic cardiomyopathy, mitral valve stenosis and insufficiency, subvalvular aortic stenosis, and single coronary artery, and various dysmorphic features including hypertelorism, epicanthic folds, low set malrotated ears, high arched palate, micrognathia, webbed neck, low posterior hairline, shield chest, pectus excavatum, cubitus valgus, borderline short metatarsals, lymphedema, redundant skin, and nail dysplasia. Because of marked lymphedema in the bilateral lower legs, lymphatic scintigraphy was carried out at 13.3 years of age, indicating extreme lymphstasis in the lower extremities, severe lymphstasis in the forearm, the elbow, and the axillary regions, moderate lymphstasis around the ascending aorta, and mild lymphstasis in the bilateral lungs. The results, in conjunction with those suggested in Turner syndrome, imply that lymphatic hypoplasia/dysplasia and resultant distended lymphatics and lymphedema are relevant to the development of not only soft tissue and visceral anomalies but also skeletal anomalies in Noonan syndrome. 相似文献
38.
Toko Maehara Kenjiro Matsumoto Kazuhide Horiguchi Makoto Kondo Satoshi Iino Shunji Horie Takahisa Murata Hirokazu Tsubone Shoichi Shimada Hiroshi Ozaki Masatoshi Hori 《British journal of pharmacology》2015,172(4):1136-1147
Background and Purpose
Post-operative ileus (POI) is induced by intestinal inflammation. Here, we aimed to clarify the effects of 5-HT3 receptor antagonists against POI.Experimental Approach
We administered three 5-HT3 receptor antagonists, ondansetron, tropisetron and palonosetron, to a mouse model of POI induced by surgical intestinal manipulation (IM). Immunohistochemistry, intestinal transit, inflammatory mediator mRNA expression and 5-HT content were measured. In some experiments, 5-HT3A receptor null mice were used.Key Results
Three 5-HT3 receptor antagonists reduced IM-induced infiltration of inflammatory CD68-positive macrophages and myeloperoxidase-stained neutrophils. Ondansetron exhibited no anti-inflammatory actions in 5-HT3A receptor null mice. Ondansetron inhibited expression of the chemokine CCL2, IL-1β, IL-6, TNF-α and iNOS mRNAs up-regulated by IM, and also ameliorated the delayed gastrointestinal transit. Peritoneal macrophages, but not most infiltrating monocyte-derived macrophages, expressed 5-HT3 receptors. IM stimulation increased the 5-HT content of peritoneal lavage fluid, which up-regulated mRNA expression of proinflammatory cytokines in peritoneal macrophages. Immunohistochemical localization of 5-HT3 receptors suggests that ondansetron suppressed expression of these mRNAs in activated peritoneal macrophages, adhering to the serosal region of the inflamed intestinal wall.Conclusion and Implications
5-HT3 receptor antagonists were anti-inflammatory, mainly targeting peritoneal macrophages expressing these receptors. They also restored the delayed gastrointestinal transit by IM. 5-HT3 receptor antagonists should be therapeutically useful agents against POI. 相似文献39.
Naoki Asayama Shinji Nagata Masanobu Yukutake Hiroki Takemoto Kenjiro Shigita Taiki Aoyama Akira Fukumoto Shinichi Mukai 《Internal medicine (Tokyo, Japan)》2021,60(9):1383
A 72-year-old man had undergone uncomplicated endoscopic submucosal dissection (ESD) with en bloc resection of a localized 20-mm IIc lesion in the anterior wall of the gastric angle. Twenty-eight days later, he was re-admitted with epigastric pain of one-week duration. Contrast-enhanced computed tomography (CT) revealed a 60-mm mass bordered by viscera; repeat endoscopy confirmed a smooth elevated submucosal tumor at the greater curvature on the oral side of the post-ESD ulcer. We diagnosed him with a perigastric abscess as a complication of ESD and performed endoscopic ultrasound-guided drainage. Subsequently, the symptoms and blood inflammatory parameters improved, and follow-up CT showed the disappearance of the abscess. 相似文献
40.
Shigemoto Yoko Matsuda Hiroshi Kimura Yukio Chiba Emiko Ohnishi Masahiro Nakaya Moto Maikusa Norihide Ogawa Masayo Mukai Yohei Takahashi Yuji Sako Kazuya Toyama Hiroshi Inui Yoshitaka Taki Yasuyuki Nagayama Hiroshi Ono Kenjiro Kono Atsushi Sekiguchi Kenji Hirano Shigeki Sato Noriko 《Annals of nuclear medicine》2022,36(5):460-467
Annals of Nuclear Medicine - Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a... 相似文献