Education of the aged in a residential setting--motivation for participation of "educational novices" within the scope of a "bring" structure

Every inhabitant aged 60 years and over in a working class district in Kassel (N = 568) was visited and invited to discussion groups (topics were "growing old", "health", "care" and others) and to excursion activities. 10% of the people were interested; 7% actually took part. In comparison with a control group of participants from other districts, it was shown that it is possible to mobilize some of those people who have had low-level schooling and only a little experience of further education.     

CGP 6809 — A new nitrosoureido-sugar derivative with activity in human tumor xenografts

Summary CGP 6809 [ethyl-6-deoxy-3,5-di-O-methyl-6-(3-methyl-3-nitrosoureido)--d-glucofuranoside] is a new methylnitrosoureido-sugar derivative that has been shown to be active against a broad spectrum of transplantable tumours in mice and rats [14]. We investigated the anti-tumour effect of CGP 6809 in ten selected, human tumour xenograft lines growing s. c. in nude mice. The p. o. administration of 125 mg/kg per day for 10–15 days was less toxic (lethality 12% in tumour-bearing nude mice) than the i. p. injection of 62.5 mg/kg per day (lethality 22%). The anti-tumour effect was similar for both application routes; two large bowel cancers responded to treatment with CGP 6809, rectal cancer CXF 158 showed a remission, and the rapidly growing, undifferentiated colonic cancer CXF 280 exhibited a transient no-change. Furthermore, remissions were observed in the epidermoid lung cancer LXF 322 and in thyroid cancer 117. Tumour progression was found in another epidermoid lung cancer and in three stomach cancers, one melanoma, and one soft tissure sarcoma. CGP 6809 is a promising new agent for clinical trials, especially for large bowel and epidermoid lung cancer.Supported in part by grant PTB 8467 from the Bundesminister für Forschung und Technologie, Bonn, FRG     

The immunofluorescence-microscopical evidence of insulin and glucagon in transplantated isolated Langerhans' islets in diabetic rats and dogs (author's transl)]

With the histochemical immunofluorescence technique were demonstrated the insulin and glucagon in the transplantated isolated Langerhans' islets in the liver at diabetic rats and dogs. Further on were tested the diabetic metabolic level with aid of clinico-chemical methods during the period of investigation (blood glucose, serum insulin, glucose tolerance test). It was found that after transplantation, 1 year by the rats and more than 8 weeks by the dogs, is existing a normoglycemic level. In the transplanted islets were seen a good immunofluorescence of insulin in the B cells and the glucagon in the A cells in all investigated stages.     

Proctolin immunoreactive neurons in the human brain stem

Using the peroxidase-antiperoxidase (PAP) technique it could be established that a variety of nerve cells of human Pons and Medulla oblongata contain proctolin-like material. These neurons belong to the Nuc. olivaris caudalis, Nuc. originis n. hypoglossi, Nuc. raphes dorsalis and the Nuc. ambiguus. Furthermore, proctolin immunoreactive peptide was found to be contained in certain fiber systems (Lemniscus medialis and fiber tracts near the Raphe).     

Metameriest?rungen und ihre Konsequenzen im S?ugetierexperiment

Zusammenfassung Störungen der Segmentierung werden bei der Hausmaus durch die Erbfaktoren Crooked tail und Rib fusions wie auch durch weitere Gene hervorgerufen. Eine Phänokopie der Mutation Rib fusions durch Sulfonylharnstoff (Rastinon) wird beschrieben. Als Ursache der beobachteten Wirbel-Rippenmißildungen ist eine Störung der Zellaggregation zu betrachten, die sich durch alle Entwicklungsphasen bis zur knöchernen Fehlbildung auswirkt.Die empfindliche Phase ist die Heraussonderung der Ursegmente aus dem undifferenzierten Mesoblasten. Ihre Beeinflussung, speziell durch hypoglykämische Agentien, wird nach Ort und Zeit analysiert und die Entwicklung der entstehenden Mißbildung untersucht.Es wird die Hypothese aufgestellt, daß in dieser Phase ein erhöhter Energiebedarf besteht, der durch eine Störung der Oxydationsprozesse blockiert werden kann.Ausgeführt mit Hilfe der Stiftung für wissenschaftliche Forschung an der Universität Zürich.     

Über die Erkennung von Keimzentrumszellen im Lymphknotenausstrich

Zusammenfassung Im Lymphknotenausstrich kommen basophile Zellen vor, die weitgehend spezifisch für die Keimzentren der Sekundärknötchen sind und als Germinoblasten bezeichnet werden. Sie sind bei follikulärer lymphatischer Hyperplasie und bei M. Brill-Symmerserheblich vermehrt. Ihre Morphologie wird im einzelnen beschrieben und durch Abbildungen belegt. Eine Unterscheidung von den basophilen Stammzellen, den großen lymphatischen Reticulumzellen der Literatur, ist möglich und nötig, da diese Zellen in Sekundärknötchen und Pulpa gleichermaßen vorkommen.     

Central and peripheral psychophysiological responses to trauma-related cues in subclinical posttraumatic stress disorder: a pilot study

This study examined verbal-subjective, peripheral and central physiological responses of motor vehicle accident (MVA) survivors with subclinical posttraumatic stress disorder (PTSD), without PTSD symptoms as well as healthy controls. Seven persons of each group were exposed to positive, neutral, accident-related and negative, non-accident-related slides. The verbal-subjective ratings of the slides did not differ between the groups. In contrast to the verbal ratings of the trauma-related materials, the behavioral and physiological responses showed a remarkable dissociation from these reports. The startle responses were enhanced to accident-related slides only in the PTSD group and MVA survivors with PTSD had a significantly lower response to the neutral slides than MVA survivors without PTSD. P200 was lower to positive, neutral and negative slides in the PTSD group compared to both other groups. The late positive complex showed no group-related effects. The data suggest that traumatized persons with PTSD show exaggerated emotional responses to trauma-related stimuli and reduced cognitive responses to several types of stimuli that may interfere with the extinction of the emotional trauma memory.     

Gene expression of connective tissue growth factor in adult mouse

The connective tissue growth factor (CTGF) is a well-known fibroblast mitogen and angiogenic factor that plays an important role in bone formation during embryogenesis. In the adult, CTGF is involved in wound healing as well as fibrotic and vascular disease. However, little is known about its physiological functions under non-pathological conditions in the adult organism. Here, we describe the cellular site of the CTGF mRNA expression in adult male and female mice as revealed by in situ hybridization histochemistry. Strong and persistent CTGF gene expression was particularly prominent in the mesenchyme of the cardiovascular system (aorta, auricular tissue, renal glomeruli), the mesenchyme surrounding the ovarian follicles or the testicular tubes in the gonadal tissue, and the subcapsular mesenchyme bordering densely innervated parts of whisker hair vibrissae. CTGF hybridization signals were not observed in the mesenchyme of many other organs including gut, muscle, liver or most parts of the lymphatic tissue. Strong expression was also present in the primary (early) ovarian follicles, the epithelium of the deep uterine glands and on myenteric ganglia neurons. These data suggest a selective and continuous mesenchymal function in the gonads and those tissues attracting very strong vascular supply or peripheral innervation. CTGF may also be involved in the cyclical proliferation of the uterine gland epithelium and in the early stages of follicular maturation, as well as in the neuropeptide regulation in the gut, cardiovascular and renal systems.