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991.
William H. Gaze Stephen M. Krone D.G. Joakim Larsson Xian-Zhi Li Joseph A. Robinson Pascal Simonet Kornelia Smalla Mohammed Timinouni Ed Topp Elizabeth M. Wellington Gerard D. Wright Yong-Guan Zhu 《Emerging infectious diseases》2013,19(7)
The clinical failure of antimicrobial drugs that were previously effective in controlling infectious disease is a tragedy of increasing magnitude that gravely affects human health. This resistance by pathogens is often the endpoint of an evolutionary process that began billions of years ago in non–disease-causing microorganisms. This environmental resistome, its mobilization, and the conditions that facilitate its entry into human pathogens are at the heart of the current public health crisis in antibiotic resistance. Understanding the origins, evolution, and mechanisms of transfer of resistance elements is vital to our ability to adequately address this public health issue. 相似文献
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The migraine headache is a common form of head and neck pain, which varies in its clinical expression, the factors that cause it, and the therapeutic approaches to its treatment and prevention. Although thought to be vascular in nature, the migraine has a considerable muscular component that is involved in its painful sequelae. Since at present there seems to be a continuum between migraine and muscular headache, the occlusal splint may prove to be an important therapic adjunct in treating migraine's painful sequelae. 相似文献
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Laura F. Newell Jennifer Dunlap Ken Gatter Grover C. Bagby Richard D. Press Rachel J. Cook Luke Fletcher Jessica T. Leonard Kelli M. Leong Joseph S. Bubalo Ali Olyaei Thomas G. Deloughery Richard T. Maziarz Erin Maynard Susan L. Orloff C. Kristian Enestvedt 《American journal of transplantation》2021,21(12):3894-3906
Graft-versus-host disease after liver transplantation (LT-GVHD) is rare, frequently fatal, and associated with bone marrow failure (BMF), cytopenias, and hyperferritinemia. Given hyperferritinemia and cytopenias are present in hemophagocytic lymphohistiocytosis (HLH), and somatic mutations in hematopoietic cells are associated with hyperinflammatory responses (clonal hematopoiesis of indeterminate potential, CHIP), we identified the frequency of hemophagocytosis and CHIP mutations in LT-GVHD. We reviewed bone marrow aspirates and biopsies, quantified blood/marrow chimerism, and performed next-generation sequencing (NGS) with a targeted panel of genes relevant to myeloid malignancies, CHIP, and BMF. In all, 12 marrows were reviewed from 9 LT-GVHD patients. In all, 10 aspirates were evaluable for hemophagocytosis; 7 had adequate DNA for NGS. NGS was also performed on marrow from an LT cohort (n = 6) without GVHD. Nine of 10 aspirates in LT-GVHD patients showed increased hemophagocytosis. Five (71%) of 7 with LT-GVHD had DNMT3A mutations; only 1 of 6 in the non-GVHD LT cohort demonstrated DNMT3A mutation (p = .04). Only 1 LT-GVHD patient survived. BMF with HLH features was associated with poor hematopoietic recovery, and DNMT3A mutations were over-represented, in LT-GVHD patients. Identification of HLH features may guide prognosis and therapeutics. Further studies are needed to clarify the origin and impact of CHIP mutations on the hyperinflammatory state.
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DA Morrow JC Fang DJ Fintel CB Granger JN Katz FG Kushner JT Kuvin J Lopez-Sendon D McAreavey B Nallamothu RL Page JE Parrillo PN Peterson C Winkelman;on behalf of the American Heart Association Council on Cardiopulmonary Critical Care Perioperative Resuscitation Council on Clinical Cardiology Council on Cardiovascular Nursing Council on Quality of Care Outcomes Research 《Circulation》2012,126(11):1408-1428