不同年龄人牙釉质对龋敏感性研究

采用细菌培养人工龋实验技术比较了青少年牙釉质和老年人牙釉质对龋病的敏感性。结果表明老年人牙釉质比青少年牙釉质薄，但脱矿改变是相似的。因此，可以认为老年人牙釉质与青少年牙釉质对龋病的敏感性无明显的差异。     

老年人原发性三叉神经痛改进撕脱术治疗的临床疗效观察

目的:探讨改进的三叉神经周围支撕脱术治疗老年人原发性三叉神经痛的临床疗效.方法:在三叉神经周围支撕脱术的基础上,采用局部骨碎块填塞神经孔治疗32例老年原发性三叉神经痛患者,其中第Ⅱ支17例,第Ⅲ支10例,第Ⅱ、Ⅲ支5例,均为单侧病变.结果:本组术后随访观察最长6年,最短5个月,显效12例,有效16例,无效4例,有效率87.5%.术后患者撕脱神经所支配区域的面部遗有不同程度的感觉麻木,无其它并发症.结论:改进撕脱术是一种治疗老年人原发性三叉神经痛简单、安全而有效的方法.     

小腿外侧皮瓣在口腔内缺损修复中的应用：附9例报道

目的研究小腿外侧皮瓣在口腔颌面软组织缺损修复中的应用。方法应用该修复方法，共进行了９例口腔颌面部肿瘤术后缺损的修复，并对该皮瓣的应用解剖，制作技术及其优缺点进行了讨论。结果应用的９侧小腿外侧皮瓣均获得成功。结论小腿外侧皮瓣，修复口腔颌面部肿瘤术后的软组织缺损并和腓骨肌皮瓣共蒂和串联修复软组织缺损均是一种可取方法     

明朝金属全冠及其粘接剂之成分分析

目的考察我国明朝（公元１３６８～１６４４年）的口腔修复技术，并为我国口腔医学史提供一些细节资料。方法借助目测及扫描电镜能谱分析，对江苏武进博物馆编号为０７５４／００４６的二颗馆藏明朝人类牙齿冠部的金属全冠及其粘接剂作了初步成分分析。结果考古分析表明，二牙系明朝嘉靖至万历年间（公元１５００～１６００年）遗物，均为上前牙且无牙体制备痕迹，金属全冠系锤造后焊接而成。能谱分析显示二金属冠分别含金７９３３％及８５８６％，含铜２０６７％及１４１４％，粘接剂内含锌元素。结论我国明朝已能利用高硬度铜金合金及粘接材料修复牙体缺损，表明我国明朝已有较成熟的口腔修复技术。     

ICRF154,加热对腺样囊性癌ACC-2细胞放射增敏的实验研究

目的研究ICRF154和加热对腺样囊性癌ACC－2细胞放射增敏的作用。方法以腺样囊性癌ACC－2细胞作为实验模型，用新抗癌药ICRF154在乏氧条件下研究该药的放射增敏性以及加热对放射的增敏效应。结果在0．2mmol／L浓度和2个小时作用时间下，ICRF154对ACC－2细胞有放射增敏作用，增敏比为1．22、放射后加热43℃，30分钟对ACC－2细胞有显著的放射增敏作用，增敏比为1．51。用上述浓度和作用时间ICRF154，作用于ACC－2细胞后进行照射，照华后即行加热43℃，30分钟，增敏比为1．67，表明ICRF154和加热的放射增敏作用有加成效应。结论ICRF154的放射增敏机制可能与其抑制拓扑异构酶Ⅱ，从而抑制DNA损伤的修复有关。     

Viral RNA splicing and papillomavirus oncogenesis

Human papillomavirus (HPV) infection is an etiologic cause leading to development of cervical and other ano-genital cancers as well as a subset of oropharyngeal cancers.     

Shaping ability of progressive versus constant taper instruments in curved root canals of extracted teeth

AIM: To compare the shaping ability of progressive versus constant taper shaft instruments in curved root canals of extracted human teeth. METHODOLOGY: A total of 40 root canals of mandibular molars with curvatures ranging between 20 degrees and 40 degrees were divided into two groups of 20 canals each and embedded in a muffle system. The root canals sectioned horizontally at three levels before preparation and then remounted into the mould. All root canals were prepared with ProTaper (progressive taper) or Hero Shaper (constant taper) instruments. Pre- and post-instrumentation radiographs and cross-sectional images were obtained. The parameters evaluated were: working safety (instrument failure, apical blockage and loss of working length) and shaping ability (straightening, cross-sectional area, transportation and centring ability). The data were analysed statistically using Student's t-test. RESULTS: No instrument fractured during preparation. One Hero Shaper instrument permanently deformed. Both instrument systems maintained working length well. The canals prepared with Hero Shaper instruments were straightened to a lesser degree (P < 0.05). ProTaper instruments removed more dentine in the coronal and the middle sections of the canals. Canals prepared with Hero Shaper instruments had less transportation (P < 0.01) and better centring ability (P < 0.05) in the apical section. CONCLUSIONS: Both instrument systems were safe to use and maintained working length well. The canals prepared with Hero Shaper had less transportation and were better centred in the apical region, possibly because their smaller taper reduced instrument stiffness.     

口呼吸与鼻呼吸儿童牙弓、基骨形态差异的研究

目的：比较口呼吸与鼻呼吸儿童牙弓、基骨形态的差异，探讨呼吸方式与牙弓、基骨形态的关系。方法：通过口鼻气流同步测定系统的随机检测，选择鼻呼吸比例≤70％(口呼吸组)及≥95％(鼻呼吸组)的11～14岁儿童各34人，测量石膏模型，比较其牙弓、基骨形态的差异。结果：①口呼吸儿童与鼻呼吸儿童相比腭盖较高，上颌基骨较窄，形态相对窄长。②口呼吸儿童比鼻呼吸儿童的上颌中、后段牙弓较长，牙弓形态相对窄长，下颌牙弓后段形态也相对窄长。结论：口呼吸可以引起儿童牙弓、基骨形态的改变。     

静态拉伸应变对人牙周膜成纤维细胞的影响

目的：研究人牙周膜成纤维细胞(PDLF)在机械拉伸应变作用下，细胞和细胞核投影面积及其细胞骨架的改变情况，探讨PDLF的形态、功能和应变之间的关系。方法：采用自制的细胞体外静态机械加载装置用不同的拉伸应变量加力于细胞上，通过激光扫描共聚焦显微镜观察细胞骨架的形态及其改变情况，并进行统计分析。结果：在8％、12％、16％力值组，细胞和细胞核投影面积随着加力时间和力值的增加而每天递增，肌动蛋白纤维也随之逐渐增粗，排列更有规律；而在20％力值组，其结果则反之。结论：静态拉伸应变可影响牙周膜成纤维细胞的骨架。