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JAN PORTERFIELD 《British Journal of Learning Disabilities》1982,10(3):94-95
It is very important for severely mentally handicapped people to use the skills that they have and to be helped to expand these skills. Being given more opportunities for participation helps severely handicapped people lead more ordinary and happier lives. This article describes ways in which staff of residential and day accommodation for severely mentally handicapped adults can give their clients more opportunities to participate actively in everyday aspects of life such as cooking, cleaning, recreation, gardening and shopping. Ways of organising staff, providing age-appropriate activities, and encouraging even the most severely handicapped to participate are also discussed. 相似文献
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expression of EGFR was determined immunohistochemically in two groups of patients with glottic carcinoma, one that recurred after a full course of radiotherapy and one that did not. Using a 4-graded scale (-, +,++,+++) 80% (12/15) of the recurrent carcinomas had a staining intensity and proportion of stained cells of ++ or more. The same figure for non-recurrent carcinomas was 39% (7/18). The difference is statistically significant (chi-squared with Yates' correction, P &<5). The results indicate that an increased expression of EGFR may influence the rate of recurrence of glottic squamous cell carcinoma after radiotherapy. 相似文献
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PAATA KHERKEULIDZE JAN JOHANSSON LARS A. CARLSON 《Acta paediatrica (Oslo, Norway : 1992)》1991,80(8-9):770-779
ABSTRACT. Cord blood from 73 full term healthy newborns and blood from adults were analysed for the protein content of high density lipoprotein subclasses separated by gradient gel electrophoresis. Cholesterol and triglyceride concentrations of very low (VLDL), low (LDL) and high (HDL) density lipoproteins were also analysed and newborns had lower concentrations of cholesterol and triglycerides in VLDL, LDL and HDL ( p < 0.001) than adults. The HDL3c subclass, comprising the smallest particles of the HDL particle spectrum, was the major component for newborns and the minor one for adults and was the only lipoprotein fraction with a higher concentration in cord than in adult blood. No sex differences were present for any of the lipoprotein levels of the newborns. Serum cholesterol concentrations were positively correlated to HDL2b r = 0.49, p < 0.001) and HD2a levels (0.42, p < 0.001), correlations confined to the cholesterol contents of HDL ( r = 0.72 and r = 0.67 respectively, both p < 0.001). Serum triglycerides were inversely correlated to HD2b and HD2a , levels in male newborns only ( r = 0.38 and r = 0.34 respectively, both p < 0.05). Irrespective of sex, gestational age and birthweight the newborns had 2 typical HDL subclass distributions, characterized by high or low levels of HDL2b and HDL2a . The newborns with high HDL2b and HDL2a levels also had low VLDL lipid levels and high HDL cholesterol concentrations. 相似文献
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目的:探讨通痹灵总旗对类风湿关节炎滑膜成纤维样细胞增殖的影响。方法:分离培养类风关患者滑膜成纤维样细胞,IL-1D刺激,不同浓度通痹灵总碱作用后,MTT法测定细胞增殖率。结果:通痹灵总碱能显著抑制滑膜成纤维样细胞增殖,并且抑制作用呈明显的量效关系。结论:通痹灵总碱可抑制类风关滑膜成纤维样细胞增殖。 相似文献
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Abstract. A case of visceral leishmaniasis is presented, where a pre-existing polycythemia vera obscured signs of the infection. Visceral leishmaniasis is a life-threatening but curable protozoan infection of the reticuloendothelial system. We wish to report a case where symptoms and signs were obscured by a preexisting hematologic disease, polycythemia vera. 相似文献