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91.
Screening for complement deficiency in bacterial meningitis 总被引:1,自引:0,他引:1
T Ernst PJ Späth C Aebi UB Schaad MG Bianchetti 《Acta paediatrica (Oslo, Norway : 1992)》1997,86(9):1009-1010
Seventy-seven children with bacterial meningitis were screened for complement deficiency. Both the classical and the alternate pathways were normal in 75 patients. Transiently reduced total haemolytic activity of the classical pathway was documented in a boy with meningococcal meningitis. Total haemolytic activity of both the classical and the alternate pathways were reduced in another patient with pneumococcal meningitis: individual complement components determination indicated predominant activation of the alternate pathway. 相似文献
92.
Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus following transient global ischemia 总被引:3,自引:0,他引:3
To investigate a potential role of ciliary neurotrophic factor (CNTF) in transient global ischemia, we have studied the postischemic regulatory changes in the expression of CNTF and its receptor, the ligand-binding alpha-subunit (CNTFRalpha). Immunoblot analysis demonstrated CNTF levels were slightly upregulated already during the first day after ischemia and then increased markedly by more than 10-fold until 2 weeks postischemia. Immunoreactivity for CNTF became detectable 1 day after ischemia and was localized in reactive astrocytes. The intensity of the immunolabeling was maximal in CA1 during the phase of neuronal cell death (days 3-7 postischemia) and in the deafferented inner molecular layer of the dentate gyrus. Upregulation of CNTF expression was less pronounced in CA3 and absent in the stratum lacunosum moleculare and the outer molecular layer of the dentate gyrus and thus did not simply correlate with astroliosis as represented by upregulation of glial fibrillary acidic protein (GFAP). As shown by in situ hybridization, expression of CNTFRalpha mRNA was restricted to neurons of the pyramidal cell and granule cell layers in control animals. Following ischemia, reactive astrocytes, identified by double labeling with antibodies to GFAP, transiently expressed CNTFRalpha mRNA with a maximum around postischemic day 3. This astrocytic response was most pronounced in CA1 and in the hilar part of CA3. These results show that CNTF and its receptor are differentially regulated in activated astrocytes of the postischemic hippocampus, indicating that they are involved in the regulation of astrocytic responses and the neuronal reorganizations occurring after an ischemic insult. 相似文献
93.
Mäurer M Becker G Wagner R Woydt M Hofmann E Puls I Lindner A Krone A 《Acta neurochirurgica》2000,142(10):1089-1097
Summary ? Purpose. In this prospective study the results of multimodal postoperative neuro-imaging were related to the survival of patients
with high grade gliomas.
Methods. All 73 patients included underwent microsurgical tumour resection and had postoperative CT and transcranial sonography (TCS)
examinations. In addition, 35 of the 73 patients received an early postoperative MRI. Patients were followed up for at least
one year.
Findings. At the end of the 7 year study period 56 patients had died. The median survival time was 371 days. Survival rate was significantly
higher in patients with anaplastic astrocytomas and inpatients displaying complete tumour resection on MRI (log-rank-test,
p<0.05) or a small postoperative residual tumour bulk on TCS (log-rank-test, p<0.05). Cox proportional hazards model identified
histological tumour grade, postoperative Karnofsky index, complete resection based on MRI and small postoperative residual
tumour mass on TCS as independent predictors of survival.
Interpretation. This study demonstrates that early postoperative neuro-imaging has prognostic implications for the survival of patients with
high grade gliomas. According to our results postoperative imaging with MRI and TCS is a valuable prognostic with regard to
patient survival and should therefore be implemented in postoperative follow-up. It also helps to evaluate the efficacy of
adjuvant therapy. 相似文献
94.
S Sakajiri J O'kelly D Yin C W Miller W K Hofmann K Oshimi L-Y Shih K-H Kim H S Sul C H Jensen B Teisner N Kawamata H P Koeffler 《Leukemia》2005,19(8):1404-1410
Dlk1 (Pref-1) is a transmembrane and secreted protein, which is a member of the epidermal growth factor-like family, homologous to Notch/Delta/Serrate. We have found by real-time RT-PCR that Dlk1 mRNA levels were high in CD34(+) cells in 10 of 12 MDS samples compared with CD34(+) cells from 11 normals. Also, Dlk1 mRNA was elevated in mononuclear, low density bone marrow cells from 11/38 MDS patients, 5/11 AML M6 and 2/4 AML M7 samples. Furthermore, 5/6 erythroleukemia and 2/2 megakaryocytic leukemia cell lines highly expressed Dlk1 mRNA. Levels of Dlk1 mRNA markedly increased during megakaryocytic differentiation of both CMK megakaryoblasts as well as normal CD34(+) hematopoietic stem cells. High serum levels of Dlk1 occurred in RA (4/10) and essential thrombocythemia (2/10) patients. Functional studies showed that forced expression of Dlk1 enhanced proliferation of K562 cells growing in 1% fetal bovine serum. Analysis of hematopoiesis of Dlk1 knockout mice suggested that Dlk1 contributed to granulocyte, megakaryocyte and B-cell clonogenic growth and was needed for generation of splenic B-cells. In summary, Dlk1 is overexpressed in selected samples of MDS (especially RA and RAEB) and AML (particularly M6, M7), and it appears to be associated with normal development of megakaryocytes and B cells. 相似文献
95.
96.
Konstantin Hofmann Doris Macchiella Roman Kloeckner Annette Hasenburg 《Clinical Case Reports》2022,10(7)
Klippel–Trénaunay syndrome (KTS) is a rare congenital disorder defined by a triad of capillary malformation, venous malformation, and soft tissue or bone hypertrophy most commonly affecting unilateral lower limbs. Due to the rarity of KTS, evidence‐based guidelines for the management of pregnancy in people with KTS are still lacking. A 34‐year‐old woman (gravidity 1; parity 0) presented at 25 weeks of gestation with malformations of the right side of her body. The extent of the KTS affecting the vulva, pelvis, and right leg was remarkable. As the prenatal MRI showed massive vascular malformations of the pelvis and vulva, we performed an elective cesarean section to avoid severe perinatal hemorrhage during a vaginal delivery. Intraoperatively, we observed varices on the parietal peritoneum within the vesico‐uterine pouch and the isthmocervical transition of the uterus, which were not identifiable in the preoperative MRI. Although KTS patients have been discouraged from pregnancy in the past because of a high risk for complications, successful and uncomplicated pregnancies are possible. For this purpose, we believe a multidisciplinary strategy that is crucial. 相似文献
97.
98.
99.
Andreas Hofmann Otto Lutterotti 《Journal of molecular medicine (Berlin, Germany)》1933,12(50):1941-1942
Zusammenfassung Die mit Thyroxin behandelten Larven zeigen das bekannte Bild der vorzeitig eintretenden Metamorphose. Die dem Thyroxin und Dekompensationsharn ausgesetzten Tiere weisen eine starke Hemmung der metamorphosebeschleunigenden Thyroxinwirkung auf. Spuren einer Wirkung des Thyroxins lassen sich nur in einer geringen Verkleinerung der Kiemen feststellen. Die helle Hautfarbe dieser Larven ist sicher als eine Wirkung des Dekompensationsharns aufzufassen, da sie sich sowohl bei diesen als auch bei den bloß mit Dekompensationsharn behandelten Larven vorfindet.Auf eine theoretische Begründung dieser aus unseren Versuchen hervorgehenden thyroxinhemmenden Wirkung des Dekompensationsharns wollen wir vorläufig nicht eingehen, sondern uns nur auf diese Mitteilung beschränken. Wir möchten aber als vielleicht nicht von der Hand zu weisenden Zusammenhang die vonEppinger seinerzeit empfohlene Schilddrüsenmedikation zum Zwecke der Entwässerung bei kardialer Dekompensation erwähnen. 相似文献
100.
Dr. A. Hofmann 《Journal of molecular medicine (Berlin, Germany)》1928,7(43):2043-2045
Zusammenfassung Es wird gezeigt, da\, wieBÜrger bereits vermutet, die Arbeitshyperglykämie mit zunehmendem Training immer geringer wird und schlie\lich verschwindet. Ferner wird gezeigt, da\ allmählich die Hypoglykämie abklingt, so da\ wir endlich bei gut trainiertem Individuum einen geraden Verlauf der Arbeitsblutzuckerkurve finden. 相似文献