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From where we stand today infections of the skeletal system will remain the most dramatic complications in orthopedic and trauma surgery in the future. The development of existing methods and the establishment of new techniques will be indispensable. The following may be conceivable: in imaging diagnostics, the further development of existing methods (CT, MRI), as well as a combination of methods (PET-CT, PET-MRI); in immunology, immune mapping for risk assessment in patients suffering from osteomyelitis; in the treatment and prevention of infections, the development of new antibiotics to treat the rapidly increasing rates of multi- and panresistant pathogens, as well as the use of modern implants with antimicrobial coatings. The above-mentioned options offer only a glimpse of developments imaginable in the future. However, in our opinion, they show the main direction of future scientific research in the field of bone infections. 相似文献
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I. Stanganelli G. Argenziano F. Sera A. Blum F. Ozdemir I.K. Karaarslan D. Piccolo K. Peris H. Kirchesch R. Bono M.A. Pizzichetta S. Gasparini R.P. Braun O. Correia L. Thomas P. Zaballos S. Puig J. Malvehy M. Scalvenzi H. Rabinovitz A. Bergamo G. Pellacani C. Longo M. Pavlovic C. Rosendahl R. Hofmann‐Wellenhof H. Cabo A.A. Marghoob D. Langford S. Astorino A.M. Manganoni J.‐Y. Gourhant J. Keir J.M. Grichnik G. Fumo H. Dong A.M. Sortino Rachou G. Ferrara I. Zalaudek 《Journal of the European Academy of Dermatology and Venereology》2012,26(8):953-963
Background Little is known about the dermoscopic features of scalp tumours. Objective To determine the dermoscopic features of scalp tumours. Methods Retrospective analysis of dermoscopic images of histopathologically diagnosed scalp tumours from International Dermoscopy Society members. Results A total of 323 tumours of the scalp from 315 patients (mean age: 52 years; range 3–88 years) were analysed. Scalp nevi were significantly associated with young age (<30 years) and exhibited a globular or network pattern with central or perifollicular hypopigmentation. Melanoma and non‐melanoma skin cancer were associated with male gender, androgenetic alopecia, age >65 years and sun damage. Atypical network and regression were predictive for thin (≤1 mm) melanomas, whereas advanced melanomas (tumour thickness > 1 mm) revealed blue white veil, unspecific patterns and irregular black blotches or dots. Conclusions The data collected provide a new knowledge regarding the clinical and dermoscopy features of pigmented scalp tumours. 相似文献
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W Chen M Mempel C Traidl‐Hofmann S Al Khusaei J Ring 《Journal of the European Academy of Dermatology and Venereology》2010,24(12):1378-1385
Gender differences in medicine have been recognized in anatomy, physiology, as well as in epidemiology and manifestations of various diseases. With respect to skin disorders, males are generally more commonly afflicted with infectious diseases while women are more susceptible to psychosomatic problems, pigmentary disorders, certain hair diseases, and particularly autoimmune as well as allergic diseases. Significantly, more female sex‐associated dermatoses can be identified than the male sex‐associated dermatoses. Dermatoses in the genital area differ between men and women. Gender differences also exist in the occurrence and prognosis of certain skin malignancies. The mechanisms underlying gender differences in skin diseases remain largely unknown. Differences in the skin structure and physiology, effect of sex hormones, ethnic background, sociocultural behaviour and environmental factors may interact to exert the influences. A better understanding of gender differences in human health and diseases will allow the development of novel concepts for prevention, diagnosis and therapy of skin diseases. 相似文献