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Simon Pape Tom J. G. Gevers Jan Maarten Vrolijk Bart van Hoek Gerd Bouma Carin M. J. van Nieuwkerk Richard Taubert Elmar Jaeckel Michael P. Manns Maria Papp Nora Sipeki Felix Stickel Cumali Efe Ersan Ozaslan Tugrul Purnak Frederik Nevens Dominik J. N. Kessener Alisan Kahraman Heiner Wedemeyer Johannes Hartl Christoph Schramm Ansgar W. Lohse Michael A. Heneghan Joost P. H. Drenth 《Liver international》2020,40(9):2164-2171
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Scott A. McDonald Anne M. Presanis Daniela De Angelis Wim van der Hoek Mariette Hooiveld Gé Donker Mirjam E. Kretzschmar 《Influenza and other respiratory viruses》2014,8(1):33-41
Objectives
To estimate, using Bayesian evidence synthesis, the age-group-specific annual incidence of symptomatic infection with seasonal influenza in the Netherlands over the period 2005–2007.Methods
The Netherlands population and age group distribution for 2006 defined the base population. The number of influenza-like illness (ILI) cases was estimated from sentinel surveillance data and adjusted for underascertainment using the estimated proportion of ILI cases that do not consult a general practitioner. The estimated number of symptomatic influenza (SI) cases was based on indirect evidence from the surveillance of ILI cases and the proportions of laboratory-confirmed influenza cases in the 2004/5, 2005/6 and 2006/7 respiratory years. In scenario analysis, the number of SI cases prevented by increasing vaccination uptake within the 65 + age group was estimated.Results
The overall symptomatic infection attack rate (SIAR) over the period 2005–2007 was estimated at 2·5% (95% credible interval [CI]: 2·1–3·2%); 410 200 SI cases (95% CI: 338 500–518 600) were estimated to occur annually. Age-group-specific SIARs were estimated for <5 years at 4·9% (2·1–13·7%), for 5–14 years at 3·0% (2·0–4·7%), for 15–44 years at 2·6% (2·1–3·2%), for 45–64 years at 1·9% (1·4–2·5%) and for 65 + years at 1·7% (1·0–3·0%). Under assumed vaccination uptake increases of 5% and 15%, 1970 and 5310 SI cases would be averted.Conclusions
By synthesising the available information on seasonal influenza and ILI from diverse sources, the annual extent of symptomatic infection can be derived. These estimates are useful for assessing the burden of seasonal influenza and for guiding vaccination policy. 相似文献35.
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Cumulative pregnancy rates after a maximum of nine cycles of modified natural cycle IVF and analysis of patient drop-out: a cohort study 总被引:1,自引:0,他引:1
Pelinck MJ Vogel NE Arts EG Simons AH Heineman MJ Hoek A 《Human reproduction (Oxford, England)》2007,22(9):2463-2470
BACKGROUND: In modified natural cycle IVF (MNV-IVF), treatment is aimed at using the one follicle that spontaneously develops to dominance, using a GnRH antagonist together with gonadotrophins in the late follicular phase only. METHODS: In this single-centre cohort study, nine cycles of MNV-IVF were offered to 268 patients. Cumulative pregnancy rates (CPRs) were calculated and drop-out was analysed. The present study is an extension of earlier studies in which three cycles of MNV-IVF were offered to the same patients. RESULTS: A total of 256 patients completed 1048 cycles (4.1 per patient). Embryo transfer rate was 36.5% per started cycle. Ongoing pregnancy rate was 7.9% per started cycle and 20.7% per embryo transfer. Including treatment-independent pregnancies, the observed CPR after up to nine cycles was 44.4% (95% confidence interval 38.3-50.5) per patient. Pregnancy rates per started cycle did not decline in higher cycle numbers (overall 9.9%). Drop-out rates were high (overall 47.8%). We found that cancellation of oocyte retrieval, fertilization failure and failure to reach embryo transfer are repeating phenomena in subsequent cycles and furthermore that these events predispose for drop-out. CONCLUSIONS: CPR after nine cycles of MNV-IVF in this study was 44.4%. Pregnancy rate per cycle did not decline in higher cycle numbers, possibly due to selective drop-out of poor prognosis patients. Due to the low-risk and patient-friendly nature of the MNC protocol, it seems a feasible treatment option for patients requiring IVF. 相似文献