全文获取类型
收费全文 | 3490篇 |
免费 | 597篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 115篇 |
妇产科学 | 151篇 |
基础医学 | 526篇 |
口腔科学 | 76篇 |
临床医学 | 540篇 |
内科学 | 738篇 |
皮肤病学 | 193篇 |
神经病学 | 180篇 |
特种医学 | 73篇 |
外科学 | 441篇 |
综合类 | 68篇 |
一般理论 | 1篇 |
预防医学 | 398篇 |
眼科学 | 58篇 |
药学 | 259篇 |
中国医学 | 13篇 |
肿瘤学 | 237篇 |
出版年
2023年 | 38篇 |
2022年 | 26篇 |
2021年 | 79篇 |
2020年 | 54篇 |
2019年 | 48篇 |
2018年 | 100篇 |
2017年 | 104篇 |
2016年 | 85篇 |
2015年 | 112篇 |
2014年 | 105篇 |
2013年 | 126篇 |
2012年 | 141篇 |
2011年 | 141篇 |
2010年 | 114篇 |
2009年 | 114篇 |
2008年 | 137篇 |
2007年 | 137篇 |
2006年 | 161篇 |
2005年 | 137篇 |
2004年 | 152篇 |
2003年 | 123篇 |
2002年 | 114篇 |
2001年 | 97篇 |
2000年 | 117篇 |
1999年 | 117篇 |
1998年 | 53篇 |
1997年 | 44篇 |
1996年 | 52篇 |
1995年 | 36篇 |
1994年 | 45篇 |
1993年 | 28篇 |
1992年 | 105篇 |
1991年 | 79篇 |
1990年 | 82篇 |
1989年 | 81篇 |
1988年 | 77篇 |
1987年 | 71篇 |
1986年 | 55篇 |
1985年 | 51篇 |
1984年 | 64篇 |
1983年 | 42篇 |
1982年 | 30篇 |
1981年 | 24篇 |
1980年 | 22篇 |
1979年 | 52篇 |
1978年 | 32篇 |
1977年 | 28篇 |
1976年 | 30篇 |
1973年 | 30篇 |
1972年 | 29篇 |
排序方式: 共有4094条查询结果,搜索用时 0 毫秒
21.
22.
23.
Anderson RA; Evans LW; Irvine DS; McIntyre MA; Groome NP; Riley SC 《Human reproduction (Oxford, England)》1998,13(12):3319-3325
Follistatin is a binding protein for the activin and inhibin family of
hormones, regulating their biological activity. In the male reproductive
tract, the interaction of these factors is likely to be involved in the
regulation of the proliferation of several cell types. We have investigated
the presence of follistatin and activin A in seminal plasma using specific
immunoassays and have localized follistatin and activin/inhibin subunits in
the adult human testis, prostate and seminal vesicle to establish their
likely sources. High concentrations of immunoreactive follistatin were
present in seminal plasma in normal men (mean 97.9 ng/ml; 1.43 ng/ml in
peripheral plasma) and were similar in men with oligo/azoospermia and
following vasectomy. Follistatin immunoreactivity was localized to both
Leydig and Sertoli cells of the testis, and to epithelial cells of the
prostate gland and seminal vesicle, which are likely to be the predominant
sources of the hormone in seminal plasma. Activin A was also present in
seminal plasma in normal men but was undetectable following vasectomy, thus
deriving from the testis. Consistent with this finding, the betaA-subunit
was immunolocalized in Sertoli and Leydig cells but was not present in
seminal vesicle or prostate gland. The functional significance of the high
concentrations of follistatin secreted into seminal plasma by the prostate
gland and/or seminal vesicle is uncertain, but they may regulate the
biological activity of testis-derived activin A and inhibin B.
相似文献
24.
25.
26.
Thirteen patients with clinical or subclinical retinal detachments were treated with photocoagulation with the aid of a device for scleral depression and the three mirror contact lens. The Eisner cone has proven helpful in achieving clinically white retinal burns at the margins of retinal breaks by displacing subretinal fluid at the time of treatment. Patients selected for treatment had adequate pigmentation for a good photocoagulation response, nearly clear ocular media, and minimal vitreo retinal traction. Extent of retinal detachment was not a determinant, but minimal retinal elevation at break locations proved beneficial. No immediate flattening or adhesion of the retina was seen on release of scleral depression at the time of photocoagulation. White clinical burns remained visible. In 12 of 13 patients the retina was in apposition to the retinal pigment epithelium around the breaks at the first post-treatment examination. The remaining subretinal fluid absorbed in even the most extensive detachment in 2 weeks. One patient with multiple breaks at the equator failed to respond to this technique and required a scleral buckle. 相似文献
27.
Hay DP 《Convulsive therapy》1989,5(1):8-16
Treatment with electroconvulsive therapy (ECT) of medically ill geriatric patients with affective disorders is described. Of 135 patients to whom ECT was administered in 6 years, 55% were over 60 years of age. One-third (45) exhibited cardiovascular (62%), central nervous system (15%), or other medical conditions (22%) increasing the risks of the treatment. Treatment strategies are described. 相似文献
28.
N. V. Dimitrov M. B. Hay S. Siew D. A. Hudler L. J. Charamella D. E. Ullrey 《The American journal of pathology》1987,126(2):376-383
Adriamycin-induced cardiomyopathy in rabbits was produced by intravenous injections of the drug with a short therapeutic schedule (3 mg/kg body wt administered as four intermittent doses). Animals receiving selenium supplementation of Adriamycin showed preservation of the normal pattern of the heart histologic picture. The protective effect of selenium was accompanied by increased selenium levels in the plasma and the heart muscle. An eventual interaction between the antitumor effect of Adriamycin and the protective effect of selenium was ruled out by in vitro experiments using the L1210 cell line. Selenium did not abrogate the antiproliferative effect of Adriamycin when the cells were treated simultaneously with both agents. The results from this study indicate that Adriamycin-induced cardiotoxicity could be prevented by selenium if the animals were pretreated with selenium, rather than simultaneous administration of both agents. The mechanism of this effect is not entirely understood. 相似文献
29.
Investigation of the binding site of mouse IgG subclasses to homologous peritoneal macrophages. 下载免费PDF全文
The binding of mouse myeloma IgG1, IgG2a, IgG2b, IgG1 Fc, IgG2b Fc and a pepsin produced C-terminal subfragment of IgG1 Fc and IgG2b Fc (provisionally identified as pFc') to mouse peritoneal macrophages was investigated. The high affinity cytophilic antibodies belonged to IgG2 subclasses and the binding site of these antibodies was located in the CH3 homology region. 相似文献
30.
P I Forrester P C Lai R L Hancock D M Hay F L Lorscheider 《International archives of allergy and applied immunology》1978,57(1):57-61
Immunoelectrophoresis showed that rabbit anti-human alpha-fetoprotein (AFP) cross-reacts with monkey AFP which was not detectable in the serum from an adult non-pregnant monkey. A heterologous radioimmunoassay of monkey AFP was developed using this antiserum which circumvented the need for purified monkey AFP. The radioimmunoassay is of sufficient sensitivity to measure AFP in maternal and fetal serum and amniotic fluid in the rhesus monkey. 相似文献