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61.
Jun Sato Yoshimasa Kitagawa Yutaka Yamazaki Hironobu Hata Takuya Asaka Masaaki Miyakoshi Shozo Okamoto Tohru Shiga Masanobu Shindoh Yuji Kuge Nagara Tamaki 《European journal of nuclear medicine and molecular imaging》2014,41(11):2031-2041
Purpose
Hypoxia, a prognostic factor in many types of cancer, can be detected by 18F-fluoromisonidazole (FMISO) positron emission tomography (PET). It is unclear whether hypoxia reflects the response to chemotherapy in patients with oral squamous cell carcinoma (OSCC). The correlations of FMISO-PET and FDG-PET with histological response to preoperative chemotherapy were therefore assessed in patients with OSCC.Methods
This study enrolled 22 patients with OSCC undergoing preoperative chemotherapy. The T-stages were T2 in 6 patients, T3 in 3, and T4a in 13, and the N-stages were N0 in 14 patients, N1 in 3, and N2 in 5. Each patient was evaluated by both FMISO-PET and FDG-PET before surgery, and the maximum standardized uptake value (SUVmax) of FDG- and FMISO-PET and tumor-muscle ratio (TMR) of FMISO-PET were measured. The threshold for the hypoxic volume based on TMR was set at 1.25. The histological response to preoperative chemotherapy was evaluated using operative materials.Results
FMISO-PET and FDG-PET detected uptake by primary OSCCs in 15 (68 %) and 21 (95 %) patients, respectively, and median SUVmaxs of FMISO- and FDG-PET in the primary site were 2.0 (range, 1.3–3.5) and 16.0 (range, 1.0–32.2), respectively. The median of FMISO TMR was 1.5 (range, 0.99–2.96). There were five cases whose FMISO TMR was less than 1.25. Histological evaluation showed good response to preoperative chemotherapy in 7 patients (32 %) and poor response in 15 (68 %). Good response was significantly more prevalent in patients with negative than positive FMISO uptake (P?0.001) and without the hypoxic area evaluated by FMISO-PET TMR (P?=?0.04), whereas FDG uptake was not significantly correlated with response to chemotherapy response. Multivariate logistic regression analysis showed that FMISO uptake was an independent significant predictor of response to preoperative chemotherapy (P?=?0.03, odds ratio?=?0.06, 95 % confidence interval?=?0.004–0.759).Conclusions
An advantage of FMISO-PET over FDG-PET for predicting histological response to preoperative chemotherapy in patients with OSCC was observed. 相似文献62.
Masakazu Sogawa Kazuo Yamamoto Manabu Haga Hisanaga Moro Hajime Ohzeki Jun-ichi Hayashi Shoji Eguchi 《General thoracic and cardiovascular surgery》1998,46(3):253-256
Acute type A aortic dissection in the presence of a previously repaired atherosclerotic descending thoracic aortic aneurysm is rarely reported. We experienced a patient who underwent an ascending aortic replacement with reconstruction of the aortic arch 16 months after repair of a descending thoracic aortic aneurysm. We succeeded in the redo operation with comprehensive techniques involving selective cerebral perfusion, deep hypothermia, early antegrade systemic circulation for cerebral protection, and femoro-femoral bypass with occlusion of the descending aorta for lower systemic perfusion as well as renal perfusion. The patient recovered and is doing well one year after the redo operation. 相似文献
63.
Kawai M Uemura H Hasumi H Osada Y Ohta J Miyoshi Y Mikata K Oh-uchi H Sugiura S Fujinami K Kubota Y 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》2005,96(3):442-447
OBJECTIVE: The prognosis of prostate cancer has been evaluated by clinical stage or pathological grade. PSA parameters including PSA density and PSA doubling time have not always precisely reflected the prognosis of prostate cancer. The aim of this study was to evaluate PSA parameters and extension of disease (EOD) grade as prognostic factors for relapsed prostate cancer. METHODS: The relationship between PSA parameters or EOD grade, and survival of 29 stage D patients with relapsed prostate cancer after initial hormone therapy was examined. RESULTS: Only EOD grade was an independent prognostic factor, even for cause-specific survival period and survival period after relapse. CONCLUSION: EOD grade was a significant prognostic factor, and in particular, very useful as a prognostic factor for patients with bone metastasis. PSA value was not always associated with tumor volume, and therefore it is not an independent prognostic factor. 相似文献
64.
Satoru Motoyama Kiyotomi Maruyama Yusuke Sato Shuetsu Usami Toshinobu Nakatsu Hajime Saito Yoshihiro Minamiya Jun-ichi Ogawa 《World journal of surgery》2009,33(3):512-517
Background Three-field lymph node dissection for thoracic esophageal cancer is associated with high morbidity and reduced quality of
life after surgery. Consequently, minimized lymphadenectomy would be desirable, if appropriate. In the present study, we retrospectively
analyzed the status of involved nodes and the direction of metastatic lymphatic flow from tumors into involved nodes to determine
whether submucosal squamous cell esophageal cancers are potential candidates for minimized lymphadenectomy.
Methods We enrolled 199 patients who received esophagectomy with extensive lymph node dissection between 1989 and 2005 and retrospectively
analyzed their prognoses, distribution of solitary metastatic lymph nodes, and the direction of metastatic lymphatic flow
from the tumor, taking into consideration tumor location and depth.
Results Of these patients with submucosal cancers, 83% had 1 or 2 involved nodes, and their esophageal cancer-specific 5-year survival
rate was 66%. Solitary lymph node metastasis did not occur in neck lymph nodes in lower thoracic submucosal esophageal cancers,
and the direction of metastatic lymphatic flow from the tumor was almost always in one direction. By contrast, T2–4 cancers
with 2–4 involved nodes had bidirectional metastatic lymphatic flow from the tumor.
Conclusions There was a difference in the status of lymph node metastasis and the direction of metastatic lymphatic flow from tumors into
involved nodes between submucosal and T2–4 thoracic squamous cell esophageal cancers. This analysis may be useful for developing
an approach to minimized lymphadenectomy for thoracic esophageal cancers. 相似文献
65.
Junko?KishikawaEmail author Shinsuke?Kazama Koji?Oba Kiyoshi?Hasegawa Hiroyuki?Anzai Yuzo?Harada Hiroyuki?Abe Keisuke?Matsusaka Kumiko?Hongo Masaru?Oba Koji?Yasuda Kensuke?Otani Takeshi?Nishikawa Toshiaki?Tanaka Junichiro?Tanaka Tomomichi?Kiyomatsu Keisuke?Hata Kazushige?Kawai Hiroaki?Nozawa Hironori?Yamaguchi Soichiro?Ishihara Eiji?Sunami Tetsuo?Ushiku Joji?Kitayama Masashi?Fukayama Norihiro?Kokudo Toshiaki?Watanabe 《Annals of surgical oncology》2016,23(6):1916-1923
Background
CD133 is a transmembrane protein that is proposed to be a stem cell marker of colorectal cancer (CRC); however, the correlation between CD133 expression and survival of CRC patients with liver metastasis has not been fully examined.Methods
CD133 expression was evaluated immunohistochemically, both in primary tumors and synchronous liver metastases of 88 consecutive CRC patients, as well as recurrent lesions in the remnant liver of 27 of these 88 patients. The relationship between CD133 expression and clinicopathological characteristics, recurrence-free survival, and overall survival (OS) was analyzed.Results
CD133 expression in liver metastases (mCD133) was detected in 50 of 88 patients (56.8 %), and had significant correlation with CD133 expression in primary lesions (pCD133) (p < 0.001). CD133 expression in liver recurrent lesions (recCD133) also had a significant correlation with mCD133 (p < 0.001). mCD133+ patients had significantly longer disease-free survival (p = 0.043) and OS (p = 0.014) than mCD133? patients. In addition, mCD133+ patients had a significantly lower rate of extrahepatic recurrence (p < 0.001).Conclusions
Patients without CD133 expression in liver metastasis had significantly shorter survival, perhaps because mCD133? patients had a significantly higher rate of extrahepatic recurrence.66.
Yoshikatsu Saiki Masaki Hata Junetsu Akasaka Takeshi Saito Koichi Tabayashi 《General thoracic and cardiovascular surgery》2005,53(12):638-640
A 77-year-old man developed deep sternal wound infection withEnterobacter cloacae 4 days after total aortic arch replacement for distal aortic arch aneurysm. Reexploration and open drainage of the mediastinum was carried out for 4 days, and the vacuum-assisted closure system was applied and continued for 10 days. During the treatment, granulation formation and neovascularization was apparently enhanced which lead us to perform omental transfer and chest closure on the 18th postoperative day. The patient has been free from recurrent sign of mediastinal infection or graft infection for the 19 months of the follow-up period. 相似文献
67.
Akira Sezai Motomi Shiono Mitsumasa Hata Akira Saito Tsutomu Hattori Shinji Wakui Masao Soeda Yuji Kasamaki Kohtaro Tokai Satoshi Saito Nanao Negishi Yukiyasu Sezai 《Annals of thoracic and cardiovascular surgery》2005,11(6):413-415
The Carpentier-Edwards pericardial bioprosthesis has been markedly improved in the long-term results and valve-related complications including valve dysfunction, compared to the previous generation bioprosthesis. We report a patient in whom transient prosthetic valve regurgitation and hemolysis occurred early after mitral valve replacement using a Carpentier-Edwards pericardial bioprosthesis and were resolved by preservative therapy. The patient was a 77-year-old female diagnosed with severe mitral valve stenosis and insufficiency. She underwent mitral valve replacement with a Carpentier-Edwards pericardial bioprosthesis. Opening and closing of the three leaflets looked good on intraoperative transesophageal echocardiography (TEE). The only prosthetic valve regurgitation was evident at the central region where the leaflets form coaptation, and no abnormal findings were seen. Serum lactate dehydrogenase (LDH) was decreased to 405 U/l after surgery. However, LDH again began to increase on the 3rd day after surgery and it increased to 1,830 U/l on the 14th day after surgery. Hemolytic urine was detected on 10th day after surgery. PVL was not detected, but moderate abnormal regurgitation from the outside of the stent pocket was detected on TEE. Revision of valve replacement was considered, but LDH thereafter to 393 U/l on 41st day after surgery. The TEE was repeated, and only a trace of central jet was detected without abnormal regurgitation, unlike the previous examination. The patient did not develop any complications thereafter and was discharged on 47th day after surgery. LDH was nearly normal at the time of discharge. 相似文献
68.
Ryoji Kawano Enjo Hata Shingo Ikeda Toshiya Yokota 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(11):611-614
We describe a resected pulmonary blastoma in an 84-year-old male, the oldest of previously reported patients. A chest X-ray showed a 2 cm-sized abnormal shadow in the left lung field. Five months later computed tomography demonstrated a well-demarcated heterogenous mass, measuring 12 cm in diameter, in the left lower lobe of the lung. This mass was diagnosed as a carcinoma using echo-guided percutaneous biopsy. The patient underwent a left lower lobectomy. The resected specimen revealed the tumor to be a pulmonary blastoma arising from lung tissue. Preoperative diagnosis of pulmonary blastoma is extremely difficult because of the histological heterogeneity of tumor. Since it has been noted that pulmonary blastoma rapidly progresses in a short period of time, surgical treatment should be undertaken as quickly as possible when such a tumor is suspected. 相似文献
69.
Nakayama J Fujioka H Nagura I Kokubu T Makino T Kuroda R Tabata Y Kurosaka M 《International orthopaedics》2009,33(1):275-280
In this study, we performed a mechanical analysis of the effect of fibroblast growth factor-2 (FGF-2) on autologous osteochondral transplantation in a rabbit model. A full-thickness cartilage defect (diameter: 5 mm; depth: 5 mm) made in the right femoral condyle was treated with osteochondral transplantation using an osteochondral plug (diameter: 6 mm; depth: 5 mm) taken from the left femoral condyle. The animals were divided into three groups: Group I, the defect was filled with 0.1 ml of gelatin hydrogel containing 1 microg of FGF-2; Group II, the defect was filled with 0.1 ml of gelatin hydrogel only; Group III, the defect was left untreated. Thereafter, osteochondral plugs were transplanted and the transplanted osteochondral grafts were evaluated mechanically and histologically at postoperative weeks 1, 3, 8 and 12. The structural property of the osteochondral graft was significantly greater in Group I than in Groups II and III at postoperative week 3. Histological analysis at 3 weeks revealed a tendency towards increased subchondral bone trabeculae in Group I compared with the other groups. Autologous osteochondral grafts transplanted with gelatin hydrogel containing FGF-2 acquired adequate stiffness at an early postoperative phase. 相似文献
70.
Masanori Ozaki MS Yusuke Inoue MD PhD Tosiaki Miyati PhD DMSc Hirohumi Hata RT Sinya Mizukami RT Shotaro Komi RT Keiji Matsunaga MD Reiko Woodhams MD PhD 《Journal of magnetic resonance imaging : JMRI》2013,37(1):172-178