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121.
Acosta Belsy Valdés Odalys Pi?ón Alexander Savón Clara Goyenechea Angel Gonzalez Grehete Gonzalez Guelsys Sarmiento Luis Más Pedro Guzmán María Guadalupe Llop Alina Perez Bre?a Ma Pilar Casas Inmaculada 《Archives of virology》2009,154(4):619-627
Adenoviruses are common pathogens that are responsible for a wide variety of infectious syndromes. The objectives of this
study were to identify and characterize members of different adenovirus species at the molecular level and to describe the
correlation between viruses and clinical syndromes during a period of 4 years. Between 2002 and 2006, 45 of 512 respiratory
specimens (8%) from patients with acute respiratory tract infection tested positive for adenovirus. Four adenovirus isolates
from samples sent for enterovirus isolation were also analyzed. This research identified 49 confirmed cases of human adenovirus
infection by PCR and/or viral culture. The most common diagnosis was upper respiratory infection (44%). Human adenovirus
D was the major species found (59%), followed by Human adenovirus
C (36%) and Human adenovirus
B (4%). Human adenovirus 5 was the major serotype found producing bronchiolitis, followed by human adenovirus 6. In patients
with upper respiratory infection, the major serotype found was human adenovirus 17. Viruses of the species Human adenovirus
D were identified in seven (77%) cases of acute febrile syndrome. Four isolates from clinical materials obtained from patients
with encephalitis, acute flaccid paralysis and meningoencephalitis were identified as belonging to the species Human adenovirus
D. Our data demonstrate a surprising result about the identification of an unusual association of viruses of the species Human adenovirus
D with different clinical syndromes. This observation could be evaluated as a possible indicator of the emergence of a novel
strain but further studies are required. 相似文献
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Neonatal ionizing radiation exposure has been shown to induce a cerebellar cytoarchitecture disarrangement. Since cerebellar abnormalities have been linked to an impairment of behavioral functions, the aim of the present work was to investigate whether exposure of developing rats to ionizing radiations can produce behavioral deficits in the adult. Male Wistar rats were X-irradiated with 5Gy within 48h after birth and were tested in a radial maze and in an open field at 30 and 90 days post irradiation. Irradiated rats showed significative changes in spatial, exploratory, and procedural parameters in the radial maze, as well as a significative decrease in anxiety-like behavior, assessed in the open field. These results suggest that ionizing radiations can induce long-lasting spatial memory and anxiety-related changes. A relationship with radiation-induced cerebellar cytoarchitecture abnormalities supports the hypothesis that cerebellar integrity seems to be critical to achieve spatial performance and emotional behavior establishment. 相似文献
127.
Reyes-Irisarri E Pérez-Torres S Miró X Martínez E Puigdomènech P Palacios JM Mengod G 《Synapse (New York, N.Y.)》2008,62(1):74-79
Phosphodiesterases (PDE) control intracellular cyclic adenosine monophosphate (cAMP) levels, which appear to play an important role in the regulation of inflammation. PDE4B is especially important in this process. Using in situ hybridization histochemistry we first mapped the expression sites of the four PDE4B splicing forms in rat brain. Using the systemic administration of the bacterial endotoxin lipopolysaccharide (LPS) as an inflammation model in rats, we found an increase in PDEB2 mRNA expression in choroid plexus. The differential expression of PDE4B spliced forms and the differential regulation of PDE4B2 in an inflammatory model further supports an involvement of this splicing variant in the inflammatory response. 相似文献
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Patricia Brañas Irene Muñoz-Gallego Elena Espartosa Noelia Moral Guadalupe Abellán Lola Folgueira 《Influenza and other respiratory viruses》2023,17(9):e13199
The COVID-19 pandemic and the implemented control measures have impacted the circulation of respiratory-transmitted pathogens. In this report, we present data from a retrospective study that included 17,883 specimens conducted between 2018 and 2022 in our facility, describing the dynamics of circulation of the main respiratory viruses. We observed a significant decrease in all viral detections (other than SARS-CoV-2) starting from March 2020. However, rhinovirus maintained comparable levels to the pre-pandemic period. Additionally, influenza viruses were not detected during the 2020–2021 season, and respiratory syncytial virus (RSV) exhibited a shift in its seasonality, with an epidemic peak occurring in the summer of 2021. 相似文献
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Hernández-Molina Gabriela Ruiz-Quintero Narlly Lima Guadalupe Hernández-Ramírez Diego Llorente-Chávez Amaya Saavedra-González Vanessa Jiménez-Soto Rodolfo Llorente Luis 《International ophthalmology》2022,42(8):2355-2361
International Ophthalmology - To evaluate CCL2, CXCL8, and CXCL10 in the tears of patients with Primary Sjögren’s syndrome (PSS) and correlate them with ocular symptoms/discomfort and... 相似文献