1-取代吡唑烷酮类抗惊构效关系的研究

1-正癸基吡唑烷-3-酮(Ⅱ结构式见表1)是欧洲专利报道的一种新型减肥剂。White等报道该化合物可通过血脑屏障,并对γ-氨基丁酸氨基转移酶(GABA-T)有强烈的抑制活性,但对谷氨酸脱羧酶的抑制作用较弱,因此可引起脑内γ-氨基丁酸(GABA)水平的升高,故我们相信应有抗惊活性。经我们合成后,发现Ⅱ确有良好的抗癲痫活性,抗小鼠最大电     

Sclerosing glomerulonephritis and malignant hypertension in a patient with congenital renal dysplasia: A case report

A patient with a single functioning kidney presented with the nephrotic syndrome. On the basis of highly selective proteinuria, a diagnosis was made of lipoid nephrosis. Steroid therapy over a 2-year period did not control the disease. The patient eventually developed end-stage renal failure and malignant hypertension. Nephrectomy was performed to control the hypertension. Histological examination showed congenital dysplasia in one kidney and sclerosing glomerulonephritis, malignant nephrosclerosis, as well as dysplastic changes in the other.     

An intraoral appliance for management of the protrusive premaxilla in bilateral cleft lip

Management of the protruding premaxilla and prolabium in bilateral cleft lip and palate can be a confounding problem. This report introduces an intraoral traction appliance that has been successfully used to move the premaxilla and prolabium to a more favorable position for surgical repair of the bilateral cleft lip. The appliance consists of a palatal baseplate for anchorage and a latex rubber traction strip looped over the prolabium to retract the premaxillary segment. The results in five cases are presented and compared to two cases where no presurgical management was performed and lip repair had been delayed for medical reasons. Advantages and disadvantages of the appliance are discussed.     

Nosocomial urinary tract infections at a pediatric hospital.

Although the epidemiology of nosocomial urinary tract infections (NUTIs) is well-described in the adult population, there is little information on children. We therefore reviewed all our patients with NUTIs, to determine their age, underlying diagnoses, microorganisms involved, use of catheters and secondary bacteremias. During a 2-year period at our institution, NUTIs accounted for 10% of all nosocomial infections (0.8 infections/100 admissions). Of 44,948 patients admitted during this period 0.7% (n = 318) acquired 351 episodes of NUTI. The patient ages ranged from 5 days to 21 years. The highest rates of NUTIs per ward (NUTI/100 admissions or transfers to the ward) were seen in the neonatal surgery (4.8), hematology/oncology (2.7), infant neurosurgery (2.1) and neonatal intensive care units (1.9). The most common organisms isolated were Escherichia coli (26%), Enterococcus sp. (15%), Pseudomonas sp. (13%), Klebsiella sp. (10%) and coagulase-negative Staphylococcus (9%). Catheterrelated infections accounted for 48% of all the NUTIs. Secondary bacteremia occurred rarely, with an incidence of 2.9% (n = 7). We conclude that NUTIs represent an important proportion (10%) of nosocomial infections in our population of hospitalized children, but secondary bacteremia is uncommon.     

Psychologic factors associated with obesity.

Obesity, particularly of the juvenile-onset type, is often associated with anger and anxiety underlying a facade of joviality. There may be marked disturbances of body image. Regardless of whether psychologic factors are the cause or result of obesity, they must be considered if efforts at weight reduction are to be successful. Substitutes for the gratification of food must be provided.     

Mechanical failure causing current leakage with unipolar pacemakers: significance and detection

Pacemaker malfunction caused by mechanical failure at the site of electrode generator connection has been observed in 5 patients fitted with unipolar pacemakers. Intermittent failure to capture occurred in one patient. The fault was the same in each case and resulted from fracture of a plastic screw designed to hold an insulating cap in place over the electrode generator connection. Changes in impulse amplitude, relative pacing threshold, and distortion of the shape of the pacemaker impulse (overshoot of the leading and trailing limbs and prolongation of the plateau length) occurred in each case, and are helpful in making the diagnosis. In contrast no significant change occurred in the frontal plane axis of the pacemaker impulse. It is concluded that current leaks in unipolar pacemakers can be of sufficient magnitude to cause failure to capture. Early detection is important and is best achieved by examination of the pacemaker signal for amplitude and shape, and assessment of pacing threshold where possible.     

Synthesis of some 5-phenylhexahydroazepino[4,5-b]indoles as potential neuroleptic agents

5-Phenyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (3a) and five derivatives have been prepared and screened for neuroleptic activity. None of the compounds antagonized methamphetamine aggregate toxicity in mice. A number of compounds, including 3a and its 3-methyl derivative 3d, showed activity in the antidepressant screens.