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Han Chung Chong Jeremy Soon Kiat Chan Chi Qin Goh Natalia V Gounko Baiwen Luo Xiaoling Wang Selin Foo Marcus Thien Chong Wong Cleo Choong Sander Kersten Nguan Soon Tan 《Molecular therapy》2014,22(9):1593-1604
Impaired wound healing is a major source of morbidity in diabetic patients. Poor outcome has, in part, been related to increased inflammation, poor angiogenesis, and deficiencies in extracellular matrix components. Despite the enormous impact of these chronic wounds, effective therapies are lacking. Here, we showed that the topical application of recombinant matricellular protein angiopoietin-like 4 (ANGPTL4) accelerated wound reepithelialization in diabetic mice, in part, by improving angiogenesis. ANGPTL4 expression is markedly elevated upon normal wound injury. In contrast, ANGPTL4 expression remains low throughout the healing period in diabetic wounds. Exogenous ANGPTL4 modulated several regulatory networks involved in cell migration, angiogenesis, and inflammation, as evidenced by an altered gene expression signature. ANGPTL4 influenced the expression profile of endothelial-specific CD31 in diabetic wounds, returning its profile to that observed in wild-type wounds. We showed ANGPTL4-induced nitric oxide production through an integrin/JAK/STAT3-mediated upregulation of inducible nitric oxide synthase (iNOS) expression in wound epithelia, thus revealing a hitherto unknown mechanism by which ANGPTL4 regulated angiogenesis via keratinocyte-to-endothelial-cell communication. These data show that the replacement of ANGPTL4 may be an effective adjunctive or new therapeutic avenue for treating poor healing wounds. The present finding also confirms that therapeutic angiogenesis remains an attractive treatment modality for diabetic wound healing. 相似文献
73.
Govind K Makharia Chris J J Mulder Khean Lee Goh Vineet Ahuja Julio C Bai Carlo Catassi Peter H R Green Siddhartha Datta Gupta Knut E A Lundin Balakrishnan Siddartha Ramakrishna Ramakant Rawat Hanish Sharma Ajit Sood Chikako Watanabe Peter R Gibson World Gastroenterology Organization‐Asia Pacific Association of Gastroenterology Working Party on Celiac Disease 《Journal of gastroenterology and hepatology》2014,29(4):666-677
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Yvonne A.L. Lim Mohammed A.K. Mahdy Tiong K. Tan Xiang T. Goh Aaron R. Jex Matthew J. Nolan Reuben S.K. Sharma Robin B. Gasser 《Molecular and cellular probes》2013,27(1):28-31
In the present study, 310 faecal samples from goats from eight different farms in Malaysia were tested for the presence of Giardia using a PCR-coupled approach. The nested PCR for SSU amplified products of the expected size (~200 bp) from 21 of 310 (6.8%) samples. Sixteen of these 21 products could be sequenced successfully and represented six distinct sequence types. Phylogenetic analysis of the SSU sequence data using Bayesian Inference (BI) identified Giardia assemblages A, B and E. The identification of the ‘zoonotic’ assemblages A and B suggests that Giardia-infected goats represent a possible reservoir for human giardiasis in Malaysia. 相似文献
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Chong Bryan Goh Rachel Sze Jen Kong Gwyneth Sim Faith Ruo En Ng Chen Han Teo Xin Yi Vanessa Quek Jing Xuan Lim Oliver Chin Yip Han Chan Siew-Pang Chan Mark Y. Tan Huay-Cheem Chew Nicholas W. S. Loh Poay Huan 《Journal of thrombosis and thrombolysis》2022,53(3):671-682
Journal of Thrombosis and Thrombolysis - Newer generation durable polymer drug-eluting stents (DP-DES) and biodegradable polymer DES (BP-DES) have similar efficacy with dual-antiplatelet therapy... 相似文献
80.
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites 总被引:12,自引:0,他引:12
Hoffman SL Goh LM Luke TC Schneider I Le TP Doolan DL Sacci J de la Vega P Dowler M Paul C Gordon DM Stoute JA Church LW Sedegah M Heppner DG Ballou WR Richie TL 《The Journal of infectious diseases》2002,185(8):1155-1164
During 1989-1999, 11 volunteers were immunized by the bites of 1001-2927 irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain NF54 or clone 3D7/NF54. Ten volunteers were first challenged by the bites of Pf-infected mosquitoes 2-9 weeks after the last immunization, and all were protected. A volunteer challenged 10 weeks after the last immunization was not protected. Five previously protected volunteers were rechallenged 23-42 weeks after a secondary immunization, and 4 were protected. Two volunteers were protected when rechallenged with a heterologous Pf strain (7G8). In total, there was protection in 24 of 26 challenges. These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks. 相似文献