An auto-anti-M causing hemolysis in vitro

A 64-year-old white man, who had never received a transfusion, was found to have anti-M in his serum. The antibody agglutinated all M+ red cells in room-temperature tests. When the ionic strength of the test milieu was reduced by use of an additive solution and the tests were incubated at 37 degrees C, the antibody hemolyzed M + N- but not M+N+ red cells. All M+ red cells reacted in indirect antiglobulin tests using polyspecific antiglobulin reagents when such tests followed an initial incubation at room temperature. When red cells and the patient's serum were warmed to 37 degrees C before being mixed, no antibody activity was demonstrable. The antibody was adsorbed to exhaustion onto M+N- and M+N+ red cells (including the patient's own), and its activity was destroyed by dithiothreitol. There was no evidence of in vivo red cell destruction by the autoantibody. No previously reported example of anti-M has been shown to activate complement in conventional in vitro tests. This example was extraordinary in that it caused sufficient complement activation to present as an in vitro hemolysin.     

钙拮抗剂在心肌肥厚时对β受体阻滞剂撤药的影响

用腹主动脉结扎4周引起的压力超负荷型左室肥厚大鼠,观察长期大剂量用美托洛尔(metoprolol,Met)突然撤药1d后的血流动力学变化、心肌β受体变化,及硝苯地平(nifedipine,Nif),间硝地平(m-nifedipine,m-Nif)对这些变化的影响。Nif和m-Nif在减轻心肌肥厚的同时,均可缓解Met撤药后平均动脉压和左室收缩压的异常增高,并可防止β受体的上调。本结果提示合用钙拮抗剂可预防β阻滞剂的撤药反应。     

Elastosis perforans serpiginosa in an adult with Down''s syndrome: report of a case with symmetrical localized involvement

Elastosis perforans serpiginosa (EPS) is a rare perforating dermatosis in which elastic fibers extrude from the papillary dermis producing umbilicated papules, characteristically arranged to form arciform or serpiginous patterns on the skin. It can be observed in patients with Down's syndrome, in whom in some cases the disease has been reported to be more widespread and to run a longer course. We present the case of a 20-year-old girl with Down's syndrome, hypothyroidism, acne and hypertrichosis, who had a 2-year history of multiple atrophic lesions with an arciform pattern on the distal extensor portions of both thighs, histologically showing the typical features of EPS.     

Effect of delta-opioid receptor agonist deltorphin on circulating concentrations of luteinizing hormone and follicle stimulating hormone in healthy fertile women

There is evidence that endogenous opioid peptides exert an inhibitory effect on pituitary luteinizing hormone (LH) secretion both in animals and in humans, by interacting with mu-opioid receptors. However, a role for delta-opioid receptors in the regulation of gonadotrophin releasing hormone (GnRH) secretion has recently been suggested. In the present study, we evaluated the effect of the highly selective delta-opioid receptor agonist deltorphin on the LH and follicle stimulating hormone (FSH) responses to naloxone in six healthy fertile women during the luteal phase of the menstrual cycle. Deltorphin infusion alone (7 microg/kg/min for 60 min) did not significantly change the basal serum concentrations of LH in this group of women. The intravenous (i.v.) bolus administration of naloxone (15 mg) induced a significant (P < 0.001) increase in serum LH concentrations (from a mean basal value of 4.24+/-1.10 IU/l to a peak of 13.27+/-1.8 IU/l). The LH response to naloxone was significantly (P < 0.001) blunted by preinfusion of deltorphin (13.27+/- 1.80 IU/l versus 4.80+/-1.18 IU/l). No significant changes in FSH concentrations were observed during deltorphin, naloxone or deltorphin plus naloxone administration. These data indicate that activation of delta-opioid receptors can reduce naloxone-induced LH release, suggesting a possible role of delta receptors in opioidergic modulation of LH secretion in women.      

线性回归和叠代排除法在脑星形细胞瘤2D1H MRS中的应用

目的 探讨Cho／NAA线性模型和叠代排除法区分脑星形细胞瘤的PROBE VOI内正常(参照)体素群、病变(排除)体素群的可行性，探讨星形细胞瘤中Cho／NAA残差Z积分分布图的意义。方法得出正常对照组和星形细胞瘤中正常(参照)体素群的Cho／HAA、Cho／Cr：得出星形细胞瘤和健康志愿者中病变(排除)体素群各体素的残差Z积分。结果 正常对照组和星形细胞瘤的正常(参照)体素群的Cho／NAA、Cho／Cr没有统计学差异；得出了Z-积分分布图。结论 Cho／NAA线性模型和叠代排除法能区分脑星形细胞瘤的正常(参照)体素群及病变(排除)体素群、Z积分图可获得生化代谢的分布信息。     

Druckschmerzhafte Brustwirbeldornfortsätze—ein quantitatives Maß von Schmerzen?

A study was conduced in 100 migraine patients and 100 control subjects who did not suffer from headaches to test Dung's hypothesis that the number of painful spinal processes in the throacic spine can be used as a quantitative measure of the degree of pain in the patient concerned. The results show significant differences in the frequency of painful spinal processes between the two study groups. This supports Dung's hypotheses. As it is easy to determine the presence of painful spinal processes the frequency of this phenomenon, the reasons for it and its significance should be the sujbects of further examination.     

Predictors of Long-Term Response With Pazopanib in Patients With Advanced Renal-Cell Carcinoma

Background

Pazopanib is among the current standards of care for first-line treatment of patients with unresectable advanced renal-cell carcinoma (aRCC) or metastatic renal-cell carcinoma. This real-world study aimed to characterize those with long-term response to pazopanib in the treatment of aRCC in a community oncology setting, and to identify predictors of long-term response.