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161.
162.
In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease 总被引:7,自引:1,他引:6
A unifying feature of the CAG expansion diseases is the formation of
intracellular aggregates composed of the mutant polyglutamine-expanded
protein. Despite the presence of aggregates in affected patients, the
precise relationship between aggregates and disease pathogenesis is
unresolved. Results from in vivo and in vitro studies of mutant huntingtin
have lead to the hypothesis that nuclear localization of aggregates is
critical for the pathology of Huntington's disease (HD). We tested this
hypothesis using a 293T cell culture model system that compared the
frequency and toxicity of cytoplasmic and nuclear huntingtin aggregates. We
first assessed the mode of nuclear transport of N-terminal fragments of
huntingtin, and show that the predicted endogenous NLS is not functional,
providing data in support of passive nuclear transport. This result
suggests that proteolysis is a necessary step for nuclear entry of
huntingtin. Additionally, insertion of nuclear import or export sequences
into huntingtin fragments containing 548 or 151 amino acids was used to
reverse the normal localization of these proteins. Changing the subcellular
localization of the fragments did not influence their total aggregate
frequency. There were also no significant differences in toxicity
associated with the presence of nuclear compared with cytoplasmic
aggregates. The findings of nuclear and cytoplasmic aggregates in affected
brains, together with these in vitro data, support the nucleus and cytosol
as subcellular sites for pathogenesis in HD.
相似文献
163.
Melissa A. Nickles MD Austin T. Coale BS William Jeremiah A. Henderson MR Kaylah E. Brown BS Dean S. Morrell MD Elizabeth L. Nieman MD 《Pediatric dermatology》2023,40(3):479-482
Topical corticosteroids (TCS) are the most commonly prescribed treatment for children with atopic dermatitis and are supported by the American Academy of Dermatology (AAD) atopic dermatitis treatment guidelines with level I strength A evidence; however, fear regarding their use, coined “steroid phobia,” is widespread. In this study, we analyzed steroid phobia-related content on popular social media platforms. We found much of this content consists of patients describing negative personal experiences with TCS and subsequently discouraging viewer use. We conclude that social media may contribute to steroid phobia, and we hope that our study motivates dermatologists with social media platforms to combat common misconceptions surrounding TCS use. 相似文献
164.
M. Reza Razeghinejad Zahra Tajbakhsh M. Hossein Nowroozzadeh Shane J. Havens Deepta Ghate Vikas Gulati 《Seminars in ophthalmology》2018,33(4):517-524
Purpose: The Water-Drinking Test (WDT) has been shown to predict the diurnal IOP change. This study evaluates the factors that may affect the WDT results. Methods: This study was conducted on 203 glaucoma patients who had undergone trabeculectomy (53) or tube surgery (31), or had a medically controlled open-angle (82) or closed-angle (37) glaucoma. IOP was measured at baseline and then every 15 minutes over a one-hour period after drinking water. The main outcome measures were IOP change (increase in IOP from baseline) at all measurement time points, IOP peak (highest IOP after drinking water), IOP fluctuation (difference between IOP peak and baseline), and assessing the association of these IOPs with a patient’s demographic and management modalities. Results: The mean age of the participants was 54±18 years, and 113 (56%) were male. Female patients showed greater IOP fluctuation than males (7.28 vs. 5.92 mm Hg; P=0.016), and a greater IOP peak (22.7 vs. 20.1 mm Hg; P=0.001). The observed associations between gender and IOP changes were only significant in <50 years. IOP at 60 minutes was greater in tube than trabeculectomy (5.6 vs. 3.1 mm Hg; P=0.007). The number of topical medications showed a direct independent association with IOP changes (P<0.001). Compared to other classes of topical medications, latanoprost showed lower WDT-IOP profile (P=0.0003). Conclusions: WDT-IOP change was diminished in subjects on latanoprost, and was greater in females <50 years, and those on greater number of medications. 相似文献
165.
Gurumoorthy Rajesh Kumar Sankar Madhavi Kaliaperumal Karthikeyan MR Thirunavakarasu 《Indian journal of dermatology》2015,60(6):556-561
Introduction:
Clinical Dermatology is a visually oriented specialty, where visually oriented teaching is more important than it is in any other specialty. It is essential that students must have repeated exposure to common dermatological disorders in the limited hours of Dermatology clinical teaching.Aim:
This study was conducted to assess the effect of clinical images based teaching as a supplement to the patient based clinical teaching in Dermatology, among final year MBBS students.Methods:
A clinical batch comprising of 19 students was chosen for the study. Apart from the routine clinical teaching sessions, clinical images based teaching was conducted. This teaching method was evaluated using a retrospective pre-post questionnaire. Students’ performance was assessed using Photo Quiz and an Objective Structured Clinical Examination (OSCE). Feedback about the addition of images based class was collected from students.Results:
A significant improvement was observed in the self-assessment scores following images based teaching. Mean OSCE score was 6.26/10, and that of Photo Quiz was 13.6/20.Conclusion:
This Images based Dermatology teaching has proven to be an excellent supplement to routine clinical cases based teaching. 相似文献166.
It is highly recommended to conduct a prophylactic check for any dental problems on patients who suffer from leukaemia before chemotherapy begins. Bacteraemia caused by oral microflora may be very dangerous for patients with haematological malignancies. However, it should be noted that the prophylactic process itself might bring about life-threatening complications if there is only a short interval between dental treatment and the beginning of chemotherapy, or if the dental treatment is too aggressive. We present a case where this prophylactic procedure produced life-threatening complications for a patient with acute myeloid leukaemia. 相似文献
167.
Jane Barlow Anita Schrader McMillan Sue Kirkpatrick Deborah Ghate Jacqueline Barnes Marjorie Smith 《Child and Adolescent Mental Health》2010,15(4):178-185
Background: Increasing recognition of the importance of maternal mental health and early parenting in optimising the later mental health of the child has given rise to new ways of working during the perinatal period. Aims: The objective of this review is to identify effective health‐led interventions to support parents, parenting and the parent‐infant relationship during the perinatal period, 1 and beyond. Method: A systematic search of key electronic databases was undertaken to identify secondary and primary sources of data addressing the research question. Twenty‐four reviews addressed the effectiveness of interventions delivered during the postnatal period in promoting closeness and sensitive parenting, infant sensory and perceptual capabilities, and positive parenting, and in addressing infant regulatory problems, maternal mental health problems, and parent‐infant relationship problems. Conclusions: A number of methods of working are recommended as part of a model of progressive‐universalism beginning ante‐natally and continuing through the first two post‐natal years, and beyond. The implications for universal, targeted and specialist healthcare services are explored, alongside the role and contribution of CAMHS practitioners. 相似文献
168.
SR Kulkarni E Fletcher AK McConnell KR Poskitt MR Whyman 《Annals of the Royal College of Surgeons of England》2010,92(8):700-705
INTRODUCTION
The aim of this pilot study was to assess the effect of pre-operative inspiratory muscle training (IMT) on respiratory variables in patients undergoing major abdominal surgery.PATIENTS AND METHODS
Respiratory muscle strength (maximum inspiratory [MIP] and expiratory [MEP] mouth pressure) and pulmonary functions were measured at least 2 weeks before surgery in 80 patients awaiting major abdominal surgery. Patients were then allocated randomly to one of four groups (Group A, control; Group B, deep breathing exercises; Group C, incentive spirometry; Group D, specific IMT). Patients in groups B, C and D were asked to train twice daily, each session lasting 15 min, for at least 2 weeks up to the day before surgery. Outcome measurements were made immediately pre-operatively and postop-eratively.RESULTS
In groups A, B and C, MIP did not increase from baseline to pre-operative assessments. In group D, MIP increased from 51.5 cmH2O (median) pre-training to 68.5 cmH2O (median) post-training pre-operatively (P < 0.01). Postoperatively, groups A, B and C showed a fall in MIP from baseline (P < 0.01, P < 0.01) and P = 0.06, respectively). No such significant reduction in postoperative MIP was seen in group D (P = 0.36).CONCLUSIONS
Pre-operative specific IMT improves MIP pre-operatively and preserves it postoperatively. Further studies are required to establish if this is associated with reduced pulmonary complications. 相似文献169.
170.
MR Youssefi SH Hoseini SM Hoseini BA Zaheri M Abouhosseini Tabari 《Iranian Journal of Parasitology》2010,5(1):61-63
Ancylostoma tubaeforme was originally described as a separate species parasitizing the cat. The adults of A. tubaeforme are 7 to 12 mm long. A. tubaeforme can be differentiated from the adults of A. braziliense and A. ceylanicum by the presence of three teeth. Here we describe the first report of A. tubaeforme in a Persian young female leopard, 2–3 years old, with head and trunk length 120 centimeters, length of tail 98 centimeters and body weight 35 kilograms. 相似文献