全文获取类型
收费全文 | 1034篇 |
免费 | 60篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 41篇 |
妇产科学 | 7篇 |
基础医学 | 124篇 |
口腔科学 | 38篇 |
临床医学 | 120篇 |
内科学 | 274篇 |
皮肤病学 | 26篇 |
神经病学 | 20篇 |
特种医学 | 229篇 |
外科学 | 58篇 |
综合类 | 18篇 |
预防医学 | 30篇 |
眼科学 | 16篇 |
药学 | 61篇 |
中国医学 | 1篇 |
肿瘤学 | 44篇 |
出版年
2022年 | 5篇 |
2021年 | 7篇 |
2020年 | 5篇 |
2019年 | 2篇 |
2018年 | 11篇 |
2017年 | 12篇 |
2016年 | 8篇 |
2015年 | 17篇 |
2014年 | 28篇 |
2013年 | 23篇 |
2012年 | 28篇 |
2011年 | 15篇 |
2010年 | 40篇 |
2009年 | 37篇 |
2008年 | 33篇 |
2007年 | 38篇 |
2006年 | 29篇 |
2005年 | 28篇 |
2004年 | 29篇 |
2003年 | 22篇 |
2002年 | 26篇 |
2001年 | 30篇 |
2000年 | 24篇 |
1999年 | 29篇 |
1998年 | 52篇 |
1997年 | 63篇 |
1996年 | 53篇 |
1995年 | 49篇 |
1994年 | 49篇 |
1993年 | 31篇 |
1992年 | 14篇 |
1991年 | 12篇 |
1990年 | 15篇 |
1989年 | 21篇 |
1988年 | 32篇 |
1987年 | 17篇 |
1986年 | 29篇 |
1985年 | 31篇 |
1984年 | 13篇 |
1983年 | 20篇 |
1982年 | 18篇 |
1981年 | 12篇 |
1980年 | 10篇 |
1979年 | 2篇 |
1978年 | 6篇 |
1977年 | 10篇 |
1976年 | 15篇 |
1975年 | 4篇 |
1973年 | 2篇 |
1969年 | 3篇 |
排序方式: 共有1112条查询结果,搜索用时 0 毫秒
991.
992.
993.
994.
995.
Courrier HM Pons F Lessinger JM Frossard N Krafft MP Vandamme TF 《International journal of pharmaceutics》2004,282(1-2):131-140
The potential of a reverse water-in-fluorocarbon (w-in-FC) emulsion stabilized with a semifluorinated amphiphile, namely C8F17(CH2)11OP(O)[N(CH2CH2)2O]2 (F8H11DMP) for drug delivery through intrapulmonary administration was investigated in the mouse. This study involved assessment of the effect of single or repeated intranasal instillations of a plain emulsion on lung tissue integrity, and evaluation of blood glucose levels in mice treated with an insulin-loaded emulsion. When instilled intranasally to mice, the plain emulsion did not alter lung tissue integrity, as demonstrated by histological staining, and did not induce any airway inflammatory reaction. Treated mice exhibited decreased body weight within the 3-4 days that followed the first emulsion administration, but this decrease was reversible within few days. Mice instilled intranasally with the insulin-loaded emulsion displayed decreased blood glucose levels within the 20 min that followed the administration, thus demonstrating the potential of the reverse w-in-FC emulsion stabilized with F8H11DMP to systemically deliver drugs, including peptides, upon lung administration. 相似文献
996.
Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized,controlled, double-blind trial 总被引:8,自引:0,他引:8
Frossard JL Spahr L Queneau PE Giostra E Burckhardt B Ory G De Saussure P Armenian B De Peyer R Hadengue A 《Gastroenterology》2002,123(1):17-23
BACKGROUND & AIMS: Emergency endoscopy may be difficult in upper gastrointestinal bleeding when blood obscures the visibility. Erythromycin, a motilin agonist, induces gastric emptying. We investigated whether an intravenous bolus infusion of erythromycin would improve the yield of endoscopy in these patients. METHODS: Patients admitted within 12 hours after hematemesis were randomly assigned to erythromycin (250 mg) or placebo, 20 minutes before endoscopy. The primary end point was endoscopic yield, as assessed by objective and subjective scoring systems and endoscopic duration. Secondary end points were the need for a second look, endoscopy-related complications, blood units transfused, and length of hospital stay. RESULTS: Fifty-one patients received erythromycin and 54 received placebo. A clear stomach was found more often in the erythromycin group (82% vs. 33%; P < 0.001). This difference remained significant in patients with cirrhosis. Erythromycin shortened the endoscopic duration (13.7 vs. 16.4 minutes in the placebo group; P = 0.036) and reduced the need for second-look endoscopy (6 vs. 17 cases; P = 0.018). Length of hospital stay and blood units transfused did not significantly differ between the 2 groups. No complications were noted. CONCLUSIONS: Erythromycin infusion before endoscopy in patients with recent hematemesis makes endoscopy shorter and easier, thereby reducing the need for a repeat procedure. 相似文献
997.
Philippe M Frossard Susan H Hill Yassin I Elshahat Eniyoma N Obineche Awais M Bokhari Gilles G Lestringant Anne John Abdishakur M Abdulle 《Clinical genetics》1998,54(4):285-293
To date, the human angiotensinogen ( AGT ) gene and some of its variants represent the best examples of genetic influences that are involved in the determination of essential hypertension (EH) and associated cardiovascular diseases (CVDs). To assess the value of genotyping AGT in a genetically homogeneous population, we carried out a retrospective, case–control study of variants M235T and T174M for putative correlations with CVDs among nationals from the United Arab Emirates (Emirati) – an ethnic group characterized by no alcohol intake and no cigarette smoking.We investigated a sample population of 229 Emirati (119 males and 110 females), comprising groups of controls and patients with clinical diagnoses of EH, left ventricular hypertrophy (LVH), ischaemic heart disease (IHD) and myocardial infarction (MI). M235T and T174M alleles were determined via assays based on the polymerase chain reaction. T174M showed no correlation with any of the four clinical entities included in this study. T235 alleles, however, occurred more frequently in the EH group and less frequently in the group of MI survivors. We also found that T235 allele frequencies decreased with age, indicating that in the Emirati population, T235 alleles are associated with a reduced life span and that this effect could occur through independent mechanisms underlying genetic susceptibilities to both EH and MI. 相似文献
998.
Hepatic malignancies: improved treatment with intraarterial Y-90 总被引:4,自引:0,他引:4
Herba MJ; Illescas FF; Thirlwell MP; Boos GJ; Rosenthall L; Atri M; Bret PM 《Radiology》1988,169(2):311-314
An improved treatment method for hepatic malignancies with yttrium-90 incorporated into the matrix of glass microspheres was evaluated prospectively. Fifteen patients with 12 metastatic colorectal cancers, one carcinoid, one islet cell tumor, and one hepatoma were treated with three dose levels: 5,000 cGy (5,000 rad), ten patients; 7,500 cGy (7,500 rad), three patients; and 10,000 cGy (10,000 rad), two patients. Mean follow-up was 7 months (range, 2-12 months). Stable disease in the liver was seen in ten patients, four of whom had concurrent progression of extrahepatic disease, which resulted in two deaths. Two additional deaths were not directly related to the malignant process. Progression of liver disease was found in five patients, with three deaths occurring at 7-8 months. No procedural, hematologic, or pulmonary complications occurred. Late gastroduodenal ulceration occurred at 6-8 weeks in three patients who had histories of chronic alcohol abuse. This method of therapy seems to be feasible and efficient. Caution is necessary with high doses or with patients with a history of or predisposition to gastroduodenal ulcers. 相似文献
999.
1000.