全文获取类型
收费全文 | 16740篇 |
免费 | 1102篇 |
国内免费 | 111篇 |
专业分类
耳鼻咽喉 | 127篇 |
儿科学 | 778篇 |
妇产科学 | 488篇 |
基础医学 | 2357篇 |
口腔科学 | 314篇 |
临床医学 | 2305篇 |
内科学 | 2872篇 |
皮肤病学 | 357篇 |
神经病学 | 1711篇 |
特种医学 | 657篇 |
外科学 | 1100篇 |
综合类 | 199篇 |
现状与发展 | 1篇 |
一般理论 | 37篇 |
预防医学 | 2275篇 |
眼科学 | 226篇 |
药学 | 894篇 |
2篇 | |
中国医学 | 11篇 |
肿瘤学 | 1242篇 |
出版年
2023年 | 141篇 |
2022年 | 186篇 |
2021年 | 352篇 |
2020年 | 267篇 |
2019年 | 386篇 |
2018年 | 403篇 |
2017年 | 358篇 |
2016年 | 315篇 |
2015年 | 394篇 |
2014年 | 555篇 |
2013年 | 856篇 |
2012年 | 1137篇 |
2011年 | 1184篇 |
2010年 | 670篇 |
2009年 | 628篇 |
2008年 | 1042篇 |
2007年 | 1060篇 |
2006年 | 1059篇 |
2005年 | 1050篇 |
2004年 | 929篇 |
2003年 | 851篇 |
2002年 | 853篇 |
2001年 | 142篇 |
2000年 | 90篇 |
1999年 | 135篇 |
1998年 | 317篇 |
1997年 | 304篇 |
1996年 | 237篇 |
1995年 | 218篇 |
1994年 | 206篇 |
1993年 | 174篇 |
1992年 | 103篇 |
1991年 | 83篇 |
1990年 | 85篇 |
1989年 | 93篇 |
1988年 | 82篇 |
1987年 | 66篇 |
1986年 | 95篇 |
1985年 | 88篇 |
1984年 | 79篇 |
1983年 | 80篇 |
1982年 | 106篇 |
1981年 | 82篇 |
1980年 | 75篇 |
1979年 | 35篇 |
1978年 | 41篇 |
1977年 | 39篇 |
1976年 | 44篇 |
1975年 | 27篇 |
1974年 | 22篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Benoit SC Air EL Wilmer K Messerschmidt P Hodge KM Jones MB Eckstein DM McOsker CC Seeley RJ Woods SC Sheldon RJ 《Physiology & behavior》2003,79(4-5):761-766
The conditioned taste aversion (CTA) is routinely used to assess the aversive consequences of anorexic agents, including potential pharmacological therapies for obesity. In a typical CTA paradigm, rats briefly sampling a novel tastant (e.g., saccharin) are acutely administered with toxin (e.g., lithium chloride, LiCl). After as few as one taste-toxin pairing, rats will reliably avoid the novel tastant. This paradigm is frequently used for the assessment of possible aversive consequences of drugs that are candidates for pharmacological therapies. The degree to which the drug supports development of a CTA is interpreted as an index of its aversive properties. Difficulties with previous work include the inability to assess affects on food intake and CTA simultaneously, particularly during chronic drug administration. We report here two novel CTA paradigms for the assessment of appetitive and aversive consequences of anorexic agents, simultaneously. In the first experiment, animals receive an intraoral infusion of a novel and highly palatable tastant immediately prior to administration of increasing doses of LiCl. In the second experiment, rats were implanted intraperitoneally with osmotic minipumps that chronically delivered a low dose of LiCl for 7 days. LiCl did not affect short or long term food intake in either experiment. However, LiCl did support the development of a CTA in both paradigms. These results suggest that both the appetitive and aversive consequences of anorexic agents can be assessed simultaneously during either acute or chronic drug administration. 相似文献
92.
Tortoriello DV; McGovern PG; Colon JM; Loughlin J; Santoro N 《Human reproduction (Oxford, England)》1998,13(11):3005-3008
We report an instance of critical ovarian hyperstimulation syndrome in a
highly responsive in-vitro fertilization patient despite the preventive
measure of a 4 day 'coast' interval during which no gonadotrophins were
administered while gonadotrophin-releasing hormone agonist therapy
continued until serum oestradiol concentrations fell below 3000 pg/ml.
相似文献
93.
Ingeborg S. Aaberge Philipp Oster Oddveig S. Helland Anne-Cathrine Kristoffersen Ellen Ypma E. Arne H?iby Berit Feiring Hanne N?kleby 《Clinical and Vaccine Immunology : CVI》2005,12(5):599-605
MenBvac and Menjugate are safe and efficacious vaccines. The purpose of this study was to evaluate safety and immunogenicity of the combination (MenB/C) of the lyophilized active components of the conjugated group C vaccine Menjugate when reconstituted with the full liquid group B outer membrane vesicle vaccine MenBvac compared to MenBvac and Menjugate given separately. At 6-week intervals, healthy adults were given one dose of MenB/C followed by two doses of MenBvac (MenB/C group), three doses of MenBvac (MenB group), or one dose of Menjugate and two doses of placebo (MenC group). Injection site reactions were frequent in all groups. However, most reactions were short lasting and mild or moderate in intensity, and the vaccines were found to be well tolerated, with no vaccine-related serious adverse events. MenB/C was immunogenic with regard to both serogroup B and C meningococci. Both the serum bactericidal assay and the enzyme-linked immunosorbent assay analyses showed that the immune responses of the combination vaccine were similar to the immune responses of its separate components MenBvac and Menjugate for both serogroup B and C. In conclusion, the combined MenB/C vaccine is safe and immunogenic. The two vaccines do not interact negatively with each other and can easily be administered in the same syringe. The induced immune responses suggest that the combined vaccine is likely to confer protection against systemic group B disease caused by the vaccine strain as well as against group C meningococcal disease. 相似文献
94.
Incidence and determinants of moderate COPD (GOLD II) in male smokers aged 40–65 years: 5-year follow up
下载免费PDF全文
![点击此处可从《The British journal of general practice》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Roeland MM Geijer Alfred PE Sachs Theo JM Verheij Philippe L Salom Jan-Willem J Lammers Arno W Hoes 《The British journal of general practice》2006,56(530):656-661
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major health problem with an estimated prevalence of 10-15% among smokers. The incidence of moderate COPD, as defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), is largely unknown. AIM: To determine the cumulative incidence of moderate COPD (forced expiratory volume in 1 second/forced vital capacity ratio [FEV1/FVC] <0.7 and FEV1 <80% predicted) and its association with patient characteristics in a cohort of male smokers. DESIGN: Prospective cohort study. SETTING: The city of IJsselstein, a small town in the Netherlands. METHOD: Smokers aged 40-65 years who were registered with local GPs, participated in a study to identify undetected COPD. Baseline measurements were taken in 1998 of 399 smokers with normal spirometry (n = 292) or mild COPD (FEV1/FVC <0.7 and FEV1 >or=80% predicted, n = 107) and follow-up measurements were conducted in 2003. RESULTS: After a mean follow-up of 5.2 years, 33 participants developed moderate COPD (GOLD II). This showed an estimated cumulative incidence of 8.3% (95% CI = 5.8 to 11.4) and a mean annual incidence of 1.6%. No participant developed severe airflow obstruction. The risk of developing moderate COPD in smokers with baseline mild COPD (GOLD I) was five times higher than in those with baseline normal spirometry (one in five versus one in 25). CONCLUSIONS: In a cohort of middle-aged male smokers, the estimated cumulative incidence of moderate COPD (GOLD II) over 5 years was relatively high (8.3%). Age, childhood smoking, cough, and one or more GP contacts for lower respiratory tract problems were independently associated with incident moderate COPD. 相似文献
95.
96.
Nannis Ellen D.; Susman Elizabeth J.; Strope Barbara E.; Woodruff Pamela J.; Hersh Stephen P.; Levine Arthur S.; Pizzo Philip A. 《Journal of pediatric psychology》1982,7(1):75-84
Physical illness is a life experience which challenges an individual'ssense of control and thus represents a potential threat to mentalhealth. For children, a serious illness threatens not only theirsense of physical and psychological well-being but also threatensthe psychological well-being of their family. In this study,severely ill patients (n = 15) and a member of their family(n = 15) were interviewed. The patients, who ranged in age from12 to 21 years, were being treated for metastatic solid tumorsor lymphoma that failed to respond to conventional therapeuticregimens. Correlates of control for the patients and familymembers, the relationship between control and developmentalstage of the patients, and the difference between levels ofcontrol in patients and family member were examined. The findingsare discussed in relation to development and their implicationsfor medical management. 相似文献
97.
Partial trisomy 22: A recognizable syndrome 总被引:3,自引:0,他引:3
A patient identified as being a partial trisomy 22 mosaic is presented. The presence of a translocation t(4;22) (pter;q12) is noted in the mother, sister and maternal aunt. Comparison is made with nine other reported cases of partial trisomy 22 confirmed by parental translocation. These suggest a definite syndrome, including mental retardation, congenital heart disease, skeletal anomalies, anti-mongoloid slant of the palpebral fissures, preauricular skin tags and low-set ears. 相似文献
98.
99.
M Avellanet RM Mirapeix D Escudero C Riera JM Domenech-Mateu 《Surgical and radiologic anatomy : SRA》1996,18(4):271-273
Summary We present a case with a characteristic magnetic resonance image (MRI) of bilateral open-lipped schizencephaly and atypical clinical presentation. The patient is still alive and in good health in her forties, she has never presented seizures, and although the motor dysfunction is well correlated with cerebral lobe involvement, neurobehavioral dysfunction is not proportional to the MR image of the cerebral malformation.
Un cas inhabituel de schizencéphalie bilatérale
Résumé Nous présentons un cas de schizencéphalie bilatérale ouverte caractérisé par une présentation clinique atypique et une imagerie par résonance magnétique nucléaire caractéristique. La patiente est encore vivante, en bonne santé, à plus de 40 ans, elle n'a jamais présenté de crise comitiale et, bien que les troubles moteurs soient bien corrélés aux altérations cérébrales, les troubles neuro-comportementaux ne sont pas proportionnels aux images IRM de cette malformation cérébrale.相似文献