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291.
Dimitrios Sotiriadis M.D. Ph.D. Aikaterini Patsatsi M.D. Elizabeth Lazaridou M.D. Ph.D. † Eleni Sotiriou M.D. Ph.D. † Despina Devliotou-Panagiotidou M.D. Ph.D. † 《Pediatric dermatology》2009,26(4):436-438
Abstract: A 3-year-old girl presented with longer hair on the left side of her scalp, coarse hair of abnormal length on her extremities, and a tuft of hair in the lumbosacral region, with all hair distributed on normally pigmented skin. Neither similar or relevant family history nor associated extracutaneous abnormalities was detected after a thorough examination. Clinical diagnosis of patchy nevoid hypetrichosis was confirmed by histology. Nevoid hypertrichosis is a rare hair growth disorder that usually presents at or soon after birth. It is characterized by patches of hypertrichosis distributed in a segmental pattern. It may be accompanied by mental, ocular, or myoskeletal abnormalities. Cases of nevoid hypertrichosis with multiple patches presenting as a solitary developmental defect have been rarely described in the literature. 相似文献
292.
Kyriaki Mystakidou Eleni Tsilika Vassilios Kouloulias Efi Parpa Emmanuela Katsouda John Kouvaris Lambros Vlahos 《Health and quality of life outcomes》2004,2(1):8
Background
This paper describes the development of a new quality of life instrument in advanced cancer patients receiving palliative care. 相似文献293.
294.
OBJECTIVE: To compare the clinical results and reproductive outcome in obese women with polycystic ovary syndrome (PCOS) following dietary intervention or treatment with metformin. METHODS: Forty-six patients with PCOS were studied prospectively in Prince Rashed Hospital, Irbid, Jordan, between January 2003 and April 2005. The women were randomly divided into 2 groups: Group 1 (n=24) was prescribed with 1200-1400 kcal/day diet (25% proteins, 25% fat, and 50% carbohydrates plus 25-30 gm of fiber per week). Group 2 (n=22) was assigned to take 850 mg of metformin twice in a continuous manner. Both treatments continued for 6 months. Clinical and biochemical data, before and after both treatments along with the reproductive outcome were compared between the 2 groups. RESULTS: There were no significant differences between the 2 groups in terms of age, body mass index (BMI) and duration of infertility. Both groups had a significant improvement after treatment in the menstrual cyclicity (66.7% and 68.2% versus 12.5% and 18.2%) and significant reduction in BMI (mean of 27.4 and 27.8 versus 32.2 and 31.9), luteinizing hormone levels (7.9+/-1.7 and 6.9+/-1.8 versus 11.8+/-2.2 and 11.5+/-1.8), and androgen (testosterone, androstenedione, dehydroepiandrosterone sulfate) concentration. The clinical, biochemical, and reproductive outcome including menstrual cycle pattern, ovulation, and pregnancy rates were similar in both groups after treatment. CONCLUSION: Amelioration of hyperinsulinemia and hyperandrogenemia with dietary intervention or metformin treatment improves significantly the clinical features and reproductive function in overweight PCOS women. 相似文献
295.
296.
A retrospective analysis of five Sabin intertypic recombinant strains, isolated from human feacal specimens during the time
period 1978–1985 in Greece, was performed by RT-PCR, Restriction Fragment Length Polymorphism (R.F.L.P.) and sequencing. Of
the studied strains, three (EPA, EPB, EPC) were found to be bi-recombinant Sabin3/Sabin2/Sabin3 (S3/S2/S3), one strain was
characterized as a probable S3/S2- CAV18 or CAV21-S2/S1 multi-recombinant (EDP11) and one was identified as a tripartite one
S3/S2/S1 (EDP12). Samples EPA, EPB and EPC presented a common recombination junction in the 2C genomic region. Moreover, strains
EPA and EPB shared also the second recombination site in the 3D genomic region, whereas the second recombination of EPC was
also determined in 3D but in a different nucleotide position. Strains EDP11 and EDP12 presented both identical recombination
motifs and recombination sites. The first was detected in the 2C genomic region and the second in the 3D region. Strain EDP11
presented an interesting feature since a sequence of 120 nucleotides seems to have derived from a member of human enteroviruses
species C (CAV18 or CAV21). This finding is of great importance, considering that this strain (EDP11) was isolated from an
area and time period, where no Coxsackie A virus or poliovirus epidemics occurred. Our study underlines the role of specific
positions and motifs of the poliovirus genomic sequences involved in recombination events and prompts that Coxsackie A viruses
belonging to human enterovirus species C (genetically closely related to PV) are considered as the possible counterparts of
the recombination. 相似文献
297.
Tseveleki V Tsagozis P Koutsoni O Dotsika E Probert L 《International immunology》2007,19(10):1183-1189
c-FLIP(L) expression in T cells is required for mounting effective T cell responses and can also be critical for effector T cell differentiation, as has recently been shown by a number of in vivo studies in conditional knockout and transgenic mouse systems. Available data supports therefore a novel immunomodulatory role of this anti-apoptotic protein besides its traditionally proposed function in homeostatic maintenance of T cell populations. In this study, the responses to infection with Leishmania major of mice over-expressing FLIP(L) specifically in the T cell compartment (TgFLIP(L)) are assessed. Although previous studies have shown that FLIP(L) drives T cells towards a T(h)2 differentiation programme in various autoimmune and allergic paradigms, in this study, we show that TgFLIP(L) are able to overcome this T(h)2 bias in a dermal L. major infection model to mount a robust T(h)1 response to pathogen and effectively clear infection. Our results suggest that vaccination protocols designed to enhance FLIP(L) expression in T cells may be useful for the treatment of autoimmune diseases like multiple sclerosis, without necessarily compromising immune responses towards infectious agents. 相似文献
298.
Petridou ET Kyllekidis S Jeffrey S Chishti P Dessypris N Stone DH 《Scandinavian journal of public health》2007,35(3):278-287
AIMS: The wide variation of unintentional (accidental) injury mortality rates in the European Union (EU) member states suggests that there is high potential for prevention. This paper attempts to quantify the potential for saving lives in this part of the world if all 25 member states were to learn from the experience of countries with advanced injury prevention records. METHODS: Unintentional injury mortality data (latest three available years), including denominator population estimates, were obtained from the World Health Organization (WHO) mortality database for all 22 EU countries with a population of more than one million. Annual average age-adjusted injury mortality rates were used to derive the potential for saving of lives under two scenarios: (a) if all EU member states matched the country with the lowest unintentional rate for all causes of injury combined; (b) if the benchmark was alternatively the country with the lowest unintentional injury cause-specific rate. Separate calculations were performed for children (0-14), adults (15-64), and the elderly (65 and over). RESULTS: Under the first scenario, over 73,000 lives could have been saved in the EU 25 in a single year, notably nearly half (47.4%) fewer unintentional injury deaths could be observed in children, over half in adult (54%), and two-fifths (38%) in the elderly. Under the second, more optimistic, scenario 59% of childhood and adult and 75% of unintentional injury deaths among the elderly would have been avoided. CONCLUSIONS: A substantial proportion of lives lost due to unintentional injury might be saved if all countries were to achieve the lowest unintentional injury mortality rates in the EU. The above calculations are based on a simple theoretical model but there is increasing evidence on the array of existing effective preventive interventions and improved trauma care calls for public health action in each member state that could in practice halt, to the extent possible, the unintentional injury epidemic. 相似文献
299.
Papavasileiou E Voyatzi A Papavasileiou K Makri A Andrianopoulou I Chatzipanagiotou S 《European journal of epidemiology》2007,22(1):77-78
A total of 170 Campylobacter jejuni strains isolated from the stool of children with clinical gastroenteritis, aged from 3 months to 14 years, were collected
during a two-year period (2004–2005). From the 170 strains 30% were resistant to ciprofloxacin (MIC ≥ 4 μg/ml), 55% to tetracycline
(MIC > 8 μg/ml), 13% to clindamycin (MIC ≥ 8 μg/ml), 4% to ampicillin (MIC > 16 μg/ml), 6% to erythromycin (MIC ≥ 8 μg/ml),
4% to coamoxiclav (MIC ≥ 16/8 μg/ml) and 0% to gentamicin. Compared to previous reports from Greece, the antimicrobial resistance
rates to erythromycin, ampicillin and coamoxiclav remain low, while they are still high for tetracycline and ciprofloxacin.
Considering similar reports from many other countries and the high incidence of Campylobacter gastroenteritis worldwide, the
value of ciprofloxacin as a first choice drug␣in the empiric treatment of the infection is questionable. 相似文献