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121.
John V. Asimakopoulos Maria K. Angelopoulou Maria-Panagiota Arapaki Alexandros Kanellopoulos Maria Dimou Xanthoula Giakoumis Eliana Konstantinou Marina Belia Chrysovalantou Chatzidimitriou Sotirios Sachanas Theodoros Iliakis Marie-Christine Kyrtsonis Marina P. Siakantaris Nora-Athina Viniou Eleni Variamis Flora N. Kontopidou Gerassimos A. Pangalis Panayiotis Panayiotidis Kostas Konstantopoulos Theodoros P. Vassilakopoulos 《British journal of haematology》2020,190(6):e335-e339
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Baloyiannis Ioannis Theodorou Eleni Sarakatsianou Chamaidi Georgopoulou Stavroula Perivoliotis Konstantinos Tzovaras George 《International journal of colorectal disease》2020,35(2):323-331
International Journal of Colorectal Disease - In order to reduce postoperative opioid administration and pain levels in patients submitted to laparoscopic colectomy, we assessed the efficacy of... 相似文献
125.
Kevin W. McConeghy PharmD MS Elizabeth White APRN PhD Orestis A. Panagiotou MD PhD Christopher Santostefano RN BSN Christopher Halladay ScM Richard A. Feifer MD MPH Carolyn Blackman MD James L. Rudolph MD Vince Mor PhD Stefan Gravenstein MD MPH 《Journal of the American Geriatrics Society》2020,68(12):2716-2720
126.
Devan Kansagara Anaïs Tuepker Sandy Joos Christina Nicolaidis Eleni Skaperdas David Hickam 《Journal of general internal medicine》2014,29(2):607-613
BACKGROUND
Quality improvement is a central goal of the patient-centered medical home (PCMH) model, and requires the use of relevant performance measures that can effectively guide comprehensive care improvements. Existing literature suggests performance measurement can lead to improvements in care quality, but may also promote practices that are detrimental to patient care. Staff perceptions of performance metric implementation have not been well-researched in medical home settings.OBJECTIVE
To describe primary care staff (clinicians and other staff) experiences with the use of performance metrics during the implementation of the Veterans Health Administration’s (VHA) Patient Aligned Care Team (PACT) model of care.DESIGN
Observational qualitative study; data collection using role-stratified focus groups and semi-structured interviews.PARTICIPANTS
Two hundred and forty-one of 337 (72 %) identified primary care clinic staff in PACT team and clinic administrative/other roles, from 15 VHA clinics in Oregon and Washington.APPROACH
Data coded and analyzed using conventional content analysis techniques.KEY RESULTS
Primary care staff perceived that performance metrics: 1) led to delivery changes that were not always aligned with PACT principles, 2) did not accurately reflect patient-priorities, 3) represented an opportunity cost, 4) were imposed with little communication or transparency, and 5) were not well-adapted to team-based care.CONCLUSIONS
Primary care staff perceived responding to performance metrics as time-consuming and not consistently aligned with PACT principles of care. The gaps between the theory and reality of performance metric implementation highlighted by PACT team members are important to consider as the medical home model is more widely implemented.127.
Isobel S. Okoye Stephanie Czieso Eleni Ktistaki Kathleen Roderick Stephanie M. Coomes Victoria S. Pelly Yashaswini Kannan Jimena Perez-Lloret Jimmy L. Zhao David Baltimore Jean Langhorne Mark S. Wilson 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(30):E3081-E3090
128.
Leslie Thomas Stayner Marie Pedersen Evridiki Patelarou Ilse Decordier Kim Vande Loock Leda Chatzi Ana Espinosa Eleni Fthenou Mark J. Nieuwenhuijsen Esther Gracia-Lavedan Euripides G. Stephanou Micheline Kirsch-Volders Manolis Kogevinas 《Environmental health perspectives》2014,122(1):100-106
Background: Water disinfection by-products have been associated with an increased cancer risk. Micronuclei (MN) frequency in lymphocytes is a marker of genomic damage and can predict adult cancer risk.Objective: We evaluated maternal exposure to drinking water brominated trihalomethanes (BTHM) in relation to MN frequency in maternal and cord blood lymphocytes.Methods: MN frequency was examined in 214 mothers and 223 newborns from the Rhea mother–child cohort in Crete, Greece, in 2007–2008. Residential BTHM water concentrations were estimated during pregnancy using tap water analyses and modeling. Questionnaires on water related habits were used to estimate BTHM exposure from all routes. Associations between BTHM and MN frequency were estimated using negative binomial regression.Results: BTHM concentrations in residential tap water during pregnancy ranged from 0.06 to 7.1 μg/L. MN frequency in maternal binucleated lymphocytes was found to increase with BTHM concentrations in residential water for exposure during the first [rate ratio (RR) for 1 μg/L = 1.05; 95% CI: 1.00, 1.11] and second trimesters (RR for 1 μg/L = 1.03; 95% CI: 1.00, 1.06), and through all routes of BTHM exposure during the first trimester (RR for 1 μg/week = 3.14; 95% CI: 1.16, 8.50).Conclusions: These findings suggest that exposure to BTHM may increase the frequency of MN in maternal binucleated lymphocytes.Citation: Stayner LT, Pedersen M, Patelarou E, Decordier I, Vande Loock K, Chatzi L, Espinosa A, Fthenou E, Nieuwenhuijsen MJ, Gracia-Lavedan E, Stephanou EG, Kirsch-Volders M, Kogevinas M. 2014. Exposure to brominated trihalomethanes in water during pregnancy and micronuclei frequency in maternal and cord blood lymphocytes. Environ Health Perspect 122:100–106; http://dx.doi.org/10.1289/ehp.1206434 相似文献
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Romain Dacquin Nicolas Bonnet Marina Stolina Chun‐Ya Han Paul Kostenuik Pierre Jurdic Serge Ferrari Eleni Douni 《Journal of bone and mineral research》2014,29(5):1158-1169
Receptor activator of NF‐κB ligand (RANKL) plays a key role in osteoclast‐induced bone resorption across a range of degenerative bone diseases, and its specific inhibition has been recently approved as a treatment for women with postmenopausal osteoporosis at high or increased risk of fracture in the United States and globally. In the present study, we generated transgenic mice (TghuRANKL) carrying the human RANKL (huRANKL) genomic region and achieved a physiologically relevant pattern of RANKL overexpression in order to establish novel genetic models for assessing skeletal and extraskeletal pathologies associated with excessive RANKL and for testing clinical therapeutic candidates that inhibit human RANKL. TghuRANKL mice of both sexes developed early‐onset bone loss, and the levels of huRANKL expression were correlated with bone resorption and disease severity. Low copy Tg5516 mice expressing huRANKL at low levels displayed a mild osteoporotic phenotype as shown by trabecular bone loss and reduced biomechanical properties. Notably, overexpression of huRANKL, in the medium copy Tg5519 line, resulted in severe early‐onset osteoporosis characterized by lack of trabecular bone, destruction of the growth plate, increased osteoclastogenesis, bone marrow adiposity, increased bone remodeling, and severe cortical bone porosity accompanied by decreased bone strength. An even more severe skeletal phenotype developed in the high copy Tg5520 founder with extensive soft tissue calcification. Model validation was further established by evidence that denosumab, an antibody that inhibits human but not murine RANKL, fully corrected the hyper‐resorptive and osteoporotic phenotypes of Tg5519 mice. Furthermore, overexpression of huRANKL rescued osteopetrotic phenotypes of RANKL‐defective mice. These novel huRANKL transgenic models of osteoporosis represent an important advance for understanding the pathogenesis and treatment of high‐turnover bone diseases and other disease states caused by excessive RANKL. © 2014 American Society for Bone and Mineral Research. 相似文献