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991.
In psychotherapy, paradoxical interventions are characterized by a deliberate reinforcement of the pathological behavior to improve the clinical condition. Such a counter‐intuitive approach can be considered when more conventional interventions fail. The development of targeted cancer therapies has enabled the selective inhibition of activated oncogenic signaling pathways. However, in advanced cancers, such therapies, on average, deliver modest benefits due to the development of resistance. Here, we review the perspective of a ‘paradoxical intervention’ in cancer therapy: rather than attempting to inhibit oncogenic signaling, the proposed therapy would further activate mitogenic signaling to disrupt the labile homeostasis of cancer cells and overload stress response pathways. Such overactivation can potentially be combined with stress‐targeted drugs to kill overstressed cancer cells. Although counter‐intuitive, such an approach exploits intrinsic and ubiquitous differences between normal and cancer cells. We discuss the background underlying this unconventional approach and how such intervention might address some current challenges in cancer therapy. 相似文献
992.
Rocha R Vitor AB Trindade E Lima R Tavares M Lopes J Dias JA 《European journal of pediatrics》2011,170(11):1471-1474
Omalizumab is currently used in severe asthma and has been tried in other allergic disorders. The authors report two patients
with multiple food allergies and eosinophilic esophagitis on a very restrictive diet who have been treated with omalizumab,
in order to improve food intolerance—the major distressing factor in their lives. The patients significantly improved in the
reported symptoms. However, no improvement was seen regarding esophageal endoscopy and histology. Given the poor histological
and endoscopy response, eosinophilic esophagitis persistence is unlikely to be IgE dependent. Omalizumab may improve the quality
of life of patients with severe food allergy by improving symptoms, but it does not appear to change endoscopic and histological
features of eosinophilic esophagitis in a short follow-up. 相似文献
993.
994.
Virgínia?Dias?Uzêda-e-Silva Tania?Tavares?Rodriguez Isadora?Almeida?Rios?Rocha Flávia?Calo?Aquino?Xavier Jean?Nunes?dos?Santos Patrícia?Ramos?Cury Luciana?Maria?Pedreira?RamalhoEmail author 《Lasers in medical science》2016,31(7):1363-1370
The aim of this study was to evaluate the influence of laser photobiomodulation in cutaneous healing of rats under a hyperlipidic diet. Forty-eight Wistar Albinus rats, weaned, received standard diet (SD) or hyperlipidic diet (HD) for 20 weeks. The groups were divided into SD rats and HD rats, SD-irradiated rats (LSD), and HD-irradiated rats (LHD). Standard cutaneous wound (1 cm2) was created on the dorsum of each rat. The irradiation started immediately after surgery and every 48 h for 7 or 14 days (λ660 nm, 40 mW, 6 J/cm2, ? 0,04 cm2, CW), when they were killed under deep anesthesia. The specimens were removed, routinely processed, stained with hematoxylin/eosin (H/E), and evaluated by light microscopy. Rats fed with hyperlipidic diet had greater intensity in the inflammatory process and prolonged hyperemia. At day 7, the intensity of inflammation was reduced in LSD and LHD groups when compared to their control groups, SD (p?=?0.002) and HD (p?=?0.02). There was an increase in fibroblast proliferation and collagen deposition, especially in the LHD group. At day 14, the HD group presented more intensive hyperemia than the SD group. It can be concluded that the hyperlipidic diet modified the inflammation pattern in wound healing and that laser light has a positive biomodulative effect on the healing process only in early stages. 相似文献
995.
Ribeiro Andressa Eveline de Lima Dias Joselúcia da Nóbrega Melo Ana Margarida dos Santos Borges Boniek Castillo Dutra de Assunção Isauremi Vieira 《Odontology / the Society of the Nippon Dental University》2022,110(3):482-488
Odontology - To evaluate the influence of the restorative approach and aging time on dentin bond strength (BS), failure mode (FM), and bottom/top microhardness ratio (B/T) in a large dentin cavity... 相似文献
996.
Pereira Ruben Silveira João Dias Susana Cardoso Ana Mata António Marques Duarte 《Clinical oral investigations》2022,26(12):7167-7177
Clinical Oral Investigations - To evaluate bleaching efficacy and oral health-related quality of life (ORHQoL) of three bleaching systems with similar hydrogen peroxide (HP) concentration for up to... 相似文献
997.
998.
Hélio Antonio Guimarães Filho Rosiane Mattar Edward Araujo Júnior Lavoisier Linhares Dias da Costa Carlos Fernando de Mello Junior Luciano Marcondes Machado Nardozza Paulo Martin Nowak Antonio Fernandes Moron 《Archives of gynecology and obstetrics》2011,283(2):213-217
Purpose
Assess intra and interobserver reproducibility of three-dimensional power Doppler (3DPD) placental vascular indices in normal pregnancies between 26 and 35 weeks. 相似文献999.
Instability after rupture of anterior cruciate ligament (ACL) may lead to recurrent episodes of giving way, an increased risk of meniscal injury and premature degenerative changes. A total of 25 cases with ACL injuries were evaluated after reconstruction with bone patellar tendon bone graft through a mini-arthrotomy. All patients were male. Maximum number of patients were between 25-30 years of age (40%). The most common modality of injury was contact sports (44%). Most common complaint was instability of knee (100%). Average Lysholm score increased from pre-operative of 47 (27-75) to post-operative of 87 (68-95). Two patients (8%) had retropatellar pain. Moderate to severe graft site tenderness was present in 4 (21%). After an average follow up of one year three months, the results were comparable with the results of arthroscopic reconstruction.Key Words: Anterior cruciate ligament reconstruction, Mini arthrotomy 相似文献
1000.
Lemos NG Dias AL Silva-Souza AT Mantovani MS 《Environmental toxicology and pharmacology》2005,19(2):197-201
Testing for environmental pollutants is an ever-growing concern. Various tests in organisms have been utilized for the detection and identification of toxic substances in the air, water and soil. In the present study, we utilized the comet assay in Tilapia rendalli to conduct an environmental assessment of Lake Igapó II, a lake located in the metropolitan area of Londrina, PR-Brazil. The results demonstrated that samples from Lake Igapó II had a significantly greater number of comets, mainly in classes 2 and 3. The results suggest a genotoxicity of the aquatic environment at Lake Igapó II and that the comet assay in T. rendalli provides adequate sensitivity to be utilized as a tool in the monitoring of water pollution and environmental risk assessment. 相似文献