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排序方式: 共有514条查询结果,搜索用时 171 毫秒
111.
Benzimra RE; Antao AJ; Donovan KL; Williams AJ 《QJM : monthly journal of the Association of Physicians》1998,91(6):417-422
Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura
(TTP) are conditions in which thrombocytopenia and microangiopathic
haemolytic anaemia are associated with organ damage due to thrombotic
microangiopathy (TMA). The prognosis for adults with HUS is variable, with
some patients presenting with an acute illness from which a full recovery
is made, whilst others develop irreversible renal failure. Evidence of
retinal ischaemia was noted on presentation in a normotensive patient with
irreversible renal failure due to HUS. This study examined prospectively
the optic fundi of all patients who subsequently presented to a single
adult renal unit (catchment population approximately 700,000) with HUS.
Eleven patients presented with HUS over 12 years (1985-1997). Six patients
with irreversible renal failure had retinal abnormalities either at the
time or within a few days of initial presentation. The other five patients
whose renal function recovered did not develop retinal changes during the
course of their illness. Retinal ischaemia associated with TMA is a poor
prognostic sign in adults with HUS.
相似文献
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U Poddar BR Thapa K Vaiphei KL Rao SK Mitra K Singh 《Archives of disease in childhood》1998,78(3):264-266
The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected to histological examination. Mean age was 7.7 years, with a male preponderance (3:1). Presentation was with rectal bleeding (94%), pallor (65%), stunted growth (53%), and oedema (47%), and the mean (SD) duration of symptoms was 33 (27) months. None had a positive family history or any congenital anomaly. Two children had six polyps up to the transverse colon; the rest had numerous polyps all over the colon. All children had juvenile polyps on histology and 10 (59%) had adenomatous changes (dysplasia). Total colectomy was done in six for intractable symptoms. Colon clearance was achieved in eight after an average 3.4 polypectomy sessions, and three were still on the polypectomy programme. In conclusion, juvenile polyposis is commonly associated with low grade dysplasia. Serial colonoscopic polypectomy is effective but colectomy is required for intractable symptoms and when clearance of the colon is not possible. 相似文献
115.
AC Fenton KL Woods R Leanage M Abu-Harb MI Levene DH Evans DJ Field 《Acta paediatrica (Oslo, Norway : 1992)》1992,81(6-7):498-503
Sick preterm infants may, under certain conditions, demonstrate blood pressure passive cerebral blood flow in response to changes in arterial carbon dioxide tension. Blood pressure in turn depends on cardiac output and peripheral resistance. A Doppler technique for assessing cardiac output compared favourably in terms of reproducibility to a thermodilution technique in a group of infants undergoing cardiac catheterization for congenital heart disease. Doppler was subsequently used to monitor changes in cardiac output following an increase in arterial carbon dioxide tension of 1 kPa in 25 ventilated preterm infants. Blood pressure increased significantly (p = 0.006). However, heart rate did not change significantly (p = 0.16) and, in addition, both stroke and minute volume decreased (p = 0.023, p = 0.02, respectively). This suggests that accompanying changes in components of peripheral resistance exert important effects on blood pressure in the preterm neonate in response to changes in arterial carbon dioxide tension. 相似文献
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Curved nailing according to Lezius and Herzer was applied to 700 of 1,062 cases of pertrochanteric fractures of the femur at the Surgical Department of the "Carl Gustav Carus" Medical Academy, Dresden, between 1964 and 1985. Complications are described, and results are generally compared with other surgical techniques used to handle pertrochanteric fractures of the femur. Lezius nailing, when compared to other methods, has proved to be a simple and reliable approach, primarily under the aspect of geriatric traumatology, and should be used on a much wider scale. 相似文献
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Christian Görgens Anja Patricia Ramme Sven Guddat Yvonne Schrader Annika Winter Eva-Maria Dehne Reyk Horland Mario Thevis 《Drug testing and analysis》2021,13(11-12):1921-1928
A fundamental challenge in preventive doping research is the study of metabolic pathways of substances banned in sport. However, the pharmacological predictions obtained by conventional in vitro or in vivo animal studies are occasionally of limited transferability to humans according to an inability of in vitro models to mimic higher order system physiology or due to various species-specific differences using animal models. A more recently established technology for simulating human physiology is the “organ-on-a-chip” principle. In a multichannel microfluidic cell culture chip, 3-dimensional tissue spheroids, which can constitute artificial and interconnected microscale organs, imitate principles of the human physiology. The objective of this study was to determine if the technology is suitable to adequately predict metabolic profiles of prohibited substances in sport. As model compounds, the frequently misused anabolic steroids, stanozolol and dehydrochloromethyltestosterone (DHCMT) were subjected to human liver spheroids in microfluidic cell culture chips. The metabolite patterns produced and circulating in the chip media were then assessed by LC-HRMS/(MS) at different time points of up to 14 days of incubation at 37°C. The overall profile of observed glucurono-conjugated stanozolol metabolites excellently matched the commonly found urinary pattern of metabolites, including 3′OH-stanozolol-glucuronide and stanozolol-N-glucuronides. Similarly, but to a lower extent, the DHCMT metabolic profile was in agreement with phase-I and phase-II biotransformation products regularly seen in postadministration urine specimens. In conclusion, this pilot study indicates that the “organ-on-a-chip” technology provides a high degree of conformity with traditional human oral administration studies, providing a promising approach for metabolic profiling in sports drug testing. 相似文献