全文获取类型
收费全文 | 2350篇 |
免费 | 141篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 96篇 |
妇产科学 | 38篇 |
基础医学 | 421篇 |
口腔科学 | 26篇 |
临床医学 | 296篇 |
内科学 | 458篇 |
皮肤病学 | 49篇 |
神经病学 | 231篇 |
特种医学 | 51篇 |
外科学 | 219篇 |
综合类 | 12篇 |
预防医学 | 208篇 |
眼科学 | 28篇 |
药学 | 189篇 |
中国医学 | 3篇 |
肿瘤学 | 158篇 |
出版年
2023年 | 17篇 |
2022年 | 19篇 |
2021年 | 45篇 |
2020年 | 32篇 |
2019年 | 46篇 |
2018年 | 69篇 |
2017年 | 47篇 |
2016年 | 57篇 |
2015年 | 58篇 |
2014年 | 90篇 |
2013年 | 120篇 |
2012年 | 189篇 |
2011年 | 204篇 |
2010年 | 109篇 |
2009年 | 95篇 |
2008年 | 163篇 |
2007年 | 157篇 |
2006年 | 150篇 |
2005年 | 134篇 |
2004年 | 111篇 |
2003年 | 118篇 |
2002年 | 95篇 |
2001年 | 24篇 |
2000年 | 20篇 |
1999年 | 26篇 |
1998年 | 30篇 |
1997年 | 20篇 |
1996年 | 27篇 |
1995年 | 15篇 |
1994年 | 13篇 |
1993年 | 11篇 |
1992年 | 16篇 |
1991年 | 12篇 |
1990年 | 11篇 |
1989年 | 19篇 |
1988年 | 10篇 |
1987年 | 14篇 |
1986年 | 10篇 |
1985年 | 12篇 |
1984年 | 6篇 |
1982年 | 5篇 |
1980年 | 7篇 |
1979年 | 8篇 |
1977年 | 7篇 |
1976年 | 6篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1971年 | 5篇 |
1967年 | 5篇 |
排序方式: 共有2508条查询结果,搜索用时 31 毫秒
61.
Lutz Philipp Breitling Heiko Müller Christa Stegmaier Matthias Kliegel Hermann Brenner 《Experimental gerontology》2012
Objectives
Recent animal studies have suggested a key role for cellular prion protein (PrPc) in the pathological consequences of amyloid plaque formation, the hallmark of Alzheimer's disease. This epidemiological study investigated whether serum concentrations of PrPc are associated with cognitive functioning in humans.Design, Setting, Participants
Cross-sectional study of 1,322 participants from the elderly general population in Germany, aged 65 + years at baseline (2000–2002).Measurements
Cognitive functioning was assessed by the COGTEL phone interview 5 years after baseline. Serum PrPc was determined by a commercial immunoassay.Results
In multiple linear regression adjusted for important confounders, subjects in higher PrPc quintiles appeared to have lower cognitive functioning scores than those in the lowest PrPc quintile. Spline regression suggested pronounced non-linearity with an inverse association between PrPc and cognitive functioning levelling off beyond median PrPc. Cognitive subdomain-specific models produced somewhat heterogeneous results.Conclusion
The findings are suggestive of an independent association of PrPc with cognitive functioning in humans. Confirmatory and longitudinal studies are needed to elucidate the potential of PrPc for applications in early risk stratification for cognitive impairment. 相似文献62.
Elisabeth V.C. Friedrich Reinhold Scherer Christa Neuper 《Clinical neurophysiology》2013,124(1):61-69
ObjectiveThe aim of this study was to examine the temporal stability of event-related desynchronization/synchronization (ERD/S) patterns over several sessions as a function of mental task, frequency band, brain region and time interval during the imagery period.MethodsNine volunteers participated in four sessions within 2 weeks of multi-channel EEG recordings. They performed seven mental tasks (i.e. mental rotation, word association, auditory imagery, mental subtraction, spatial navigation, imagery of familiar faces, motor imagery) during 7-s imagery periods. Cronbach’s alpha coefficients were calculated over sessions to evaluate the stability of ERD/S values.ResultsThe word association, mental subtraction and spatial navigation task showed highest stability. Cronbach’s alpha coefficients were highest in the alpha bands (7–10, 10–13 Hz), poorer in the beta bands (13–20, 20–30 Hz) and poorest in the theta band (4–7 Hz). In the majority of tasks, the first time interval and posterior left regions showed highest stability and strongest ERD in the alpha and beta bands.ConclusionStability of ERD/S is strongly dependent on the specific task and differs between time intervals of the imagery period. Furthermore, stability was related to ERD in the alpha and beta bands.SignificanceThe reliability of brain activation patterns is highly relevant for brain–computer interface developments. 相似文献
63.
64.
Hunger M Schunk M Meisinger C Peters A Holle R 《Journal of diabetes and its complications》2012,26(5):413-418
ObjectivesObesity is known to be an important risk factor for type 2 diabetes and its related comorbid conditions; however, its specific impact on generic health-related quality of life (HRQL) is less clear. The objective of this study was to estimate the association between body mass index (BMI) and HRQL in individuals with type 2 diabetes.MethodsThe EQ-5D quality of life questionnaire was administered in a follow-up of 10,385 participants aged 33–94 of the population-based German MONICA/KORA surveys. 1033 participants with type 2 diabetes were identified by self-report combined with validated physician diagnoses. Semiparametric additive regression models were used to estimate the effect of BMI on EQ-5D health utilities adjusted for age, sex, education and comorbidities.ResultsBMI was significantly associated with EQ-5D health utilities even after adjustment for macro- and microvascular complications. The functional relationship between BMI and utilities was nonlinear, reflecting optimal health around 26 kg/m2 and significantly decreasing health utilities with increasing levels of overweight and obesity (? 0.09 points between BMI values 26 and 40). Among the diabetic complications, the history of a stroke (? 0.13) and neuropathy (? 0.10) were the strongest predictors of reduced health utility scores.ConclusionsBMI is strongly associated with health utilities in persons with type 2 diabetes. This suggests that lifestyle measures to reduce obesity can markedly improve patients' health-related quality of life and that the negative effect of potential weight gain should be taken into account when determining patient preferences for different type 2 diabetes treatment options. 相似文献
65.
66.
Petersen HH Larsen MC Nielsen OW Kensing F Svendsen JH 《Journal of interventional cardiac electrophysiology》2012,34(3):317-324
Purpose
The study aim was to evaluate patient acceptance and content with remote follow-up (FU) of their implantable cardioverter defibrillator (ICD) and to estimate patients?? wish for changes in remote follow-up routines.Methods
Four hundred seventy-four ICD patients at the device follow-up clinic at Rigshospitalet using CareLink? (Medtronic) remote follow-up, who had made ??2 transmissions, received a questionnaire.Results
Three hundred eighty-five patients (81.2%) answered. Mean time with ICD was 56?±?45?months and mean age was 62?±?13?years; 80% was male. Diagnosis related to ICD implant was: ischemic heart disease in 56% and dilated cardiomyopathy in 21%. Twenty-six percent had primary prophylactic indication. Mean time on remote FU was 16.4?±?6.9?months. Mean time spent on in-clinic FU (two-way transport and FU) was 4?h and 36?min?±?7?h and 50?min, excluding 12 patients from Greenland and Faroe Islands. Ninety-five percent of the patients was very content or content with remote FU compared to in-clinic FU; 3% was less content and 2% was not content. For scheduled transmissions, 21% of the patients wished for a faster reply (sms or e-mail) compared to current practice with a letter. Eighty-four percent preferred more detailed information concerning ICD leads, battery status, and ICD therapies. A total of 96 patients (25%) had performed extra unscheduled remote transmissions: 20 due to shock, 20 due to alarm, 35 due to palpitations, and 18 for other or combined reasons.Conclusion
Ninety-five percent of the patients were content with the remote FU. Only 25% had unscheduled transmissions and most unscheduled transmissions were for appropriate reasons. Eighty-four percent of the patients wished for a more detailed response and 21% wished for a faster reply after routine transmissions. 相似文献67.
Christa?Kasang Albrecht?Ulmer Norbert?Donhauser Barbara?Schmidt August?Stich Hartwig?Klinker Samuel?Kalluvya Eleni?Koutsilieri Axel?Rethwilm Carsten?SchellerEmail author 《BMC infectious diseases》2012,12(1):14
Background
HIV-associated general immune activation is a strong predictor for HIV disease progression, suggesting that chronic immune activation may drive HIV pathogenesis. Consequently, immunomodulating agents may decelerate HIV disease progression. 相似文献68.
Charbel G. Salamon Christa Lewis Jennifer Priestley Emil Gurshumov Patrick J. Culligan 《International urogynecology journal》2013,24(8):1371-1375
Introduction and hypothesis
To prospectively evaluate the use of a particular polypropylene Y mesh for robotic sacrocolpopexy.Methods
This was a prospective study of 120 patients who underwent robotic sacrocolpopexy. We compared preoperative and 12-month postoperative objective and subjective assessments via the Pelvic Organ Prolapse Quantification (POP-Q), the Pelvic Floor Distress Inventory, Short Form 20 (PFDI-20); the Pelvic Floor Impact Questionnaire, Short Form 7 (PFIQ-7); and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire 12 (PISQ-12). Objective “anatomical success” was defined as POP-Q stage 0 or 1 at all postoperative intervals. We further defined “clinical cure” by simultaneously considering POP-Q points and subjective measures. To be considered a “clinical cure,” a given patient had to have all POP-Q points ≤0, apical POP-Q point C ≤5, no reported pelvic organ prolapse symptoms on the PFDI-20, and no reoperation for prolapse at all postoperative intervals.Results
Of the 120 patients, 118 patients completed the 1-year follow-up. The objective “anatomical success” rate was 89 % and the “clinical cure” rate was 94 %. The PFDI-20 mean score improved from 100.4 at baseline to 21.0 at 12 months (p?<?0.0001); PFIQ-7 scores improved from 61.6 to 8.0 (p?<?0.0001); and PISQ-12 scores improved from 35.7 to 38.6 (p?<?0.0009). No mesh erosions or mesh-related complications occurred.Conclusion
The use of this ultra-lightweight Y mesh for sacrocolpopexy, eliminated the mesh-related complications in the first postoperative year, and provided significant improvement in subjective and objective outcomes. 相似文献69.
Abstract The aim of this study was to identify personality factors predicting psychotherapy utilization on the basis of personality pathology, affect regulation and interpersonal functioning. The authors assessed affectivity (using the Affect Experience and Affect Regulation Q-Sort), interpersonal context (using the Quality of Object Relations Scale), and character pathology (using the Shedler–Westen Assessment Procedure-200). Combination of instruments showed one stable factor predictive for nonengagement in psychotherapy, revealing an externalizing personality dimension, dominated by externalizing defenses, acting out, deficient superego functions, and impairment in reflective functioning and in relating to others. Stability of the predictive power of this personality factor for therapy engagement could be shown, and replication in two other samples confirmed the findings. The results highlight the importance of measuring affect-regulatory mechanisms, and clinical implications for intervention techniques are discussed. 相似文献
70.
Peter B. Marschik Walter E. Kaufmann Jeff Sigafoos Thomas Wolin Dajie Zhang Katrin D. Bartl-Pokorny Giorgio Pini Michele Zappella Helen Tager-Flusberg Christa Einspieler Michael V. Johnston 《Research in developmental disabilities》2013,34(4):1236-1239
We delineated the achievement of early speech-language milestones in 15 young children with Rett syndrome (MECP2 positive) in the first two years of life using retrospective video analysis. By contrast to the commonly accepted concept that these children are normal in the pre-regression period, we found markedly atypical development of speech-language capacities, suggesting a paradigm shift in the pathogenesis of Rett syndrome and a possible approach to its early detection. 相似文献